epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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SIF-seq Sifts Out Stem Cell Enhancer Gold

April 10, 2014

Searching for functional enhancers is sort of like panning for gold; there is enormous potential for riches, but the task is akin to finding a needle in a stack of needles. A team from the Berkeley National Laboratory decided to apply their own gold rush-style, enhancer mining techniques to develop a new method for the discovery of functional enhancers aided […]

Mood Killer: DNA Methylation Linked to Depressive Disorder

April 10, 2014

There aren’t a lot of laughs to be had when discussing the very real and increasing problem of depression, but some new research supported by the brain initiative on sets of twins may help to lighten the mood a bit. Studies have begun popping up showing that epigenetic marks can be used to show if someone has […]

Zymo Research Converts Sequencers into Epigenetic Analyzers

April 7, 2014

Next-Gen Sequencing (NGS) has revolutionized scientific research, but when it comes to epigenetic exploration, scientists have had to make do with sequencing library prep methods from other non-epigenetic applications. The crew at Zymo Research has found a way to adapt sequencers for epigenetic research, without having to completely retrofit the instrument. With the introduction of […]

Take the BS Out of Bisulfite Data Analysis with the DMAP Analysis Suite

April 2, 2014

Tools and databases always make mapping our world a little easier, whether its used to train as Google’s next pokemaster or figuring out what to do with your heaps of fancy new reduced representation bisulphite sequencing (RRBS) or whole genome bisulphite sequencing (WGBS) data. A talented team of epigenome hackers from the University of Otago (New Zealand) have just put […]

Histone Code Tips the Scales of Development

March 31, 2014

All of life is a balancing act. Whether you’re walking the tight-rope in a circus, or the epigenome regulating gene expression its all about treading a fine line. Recently a team from the Institute of Medical Biology in Singapore found, while examining frog development, that there is an optimal ratio of the repressive histone H3 and […]

DNA Methylation Sorts Out Cell Type Heterogeneity

March 31, 2014

While all of our cells share an almost indistinguishable genome, the variation created by the epigenome makes sorting and tackling the heterogeneity of cell types in your favorite homogenate a bigger task than finding a Yeti in a snow storm. Now a search and rescue team from Brown University has utilized DNA methylation profiles to breathe […]

Transgenerational Epigenetic Inheritance Timeline

March 17, 2014

Molecular inheritance is what genetics is all about, so here we highlight some examples where the epigenome plays a key role in inheritance.

Histone Acetyltransferase Circumin Eases Neuropathic Pain

March 17, 2014

There’s definitely not much “gain” in Neuropathic Pain, but recently some Histone Acetyltranferases (HATs) have begun to show great promise in the clinic. This includes circumin, which is used to treat a number of conditions like Alzheimer’s, Cancer, Arthritis and Neuropathic Pain. Circumin is a (p300/CREB-binding protein (CBP)) inhibitor of HAT activity, but the biological mechanisms for […]

Bees Join the Genomic Imprinting Hive

March 17, 2014

The buzz had always been that DNA methylation mechanisms appear absent in most insects, but are known to occur in social insects, like bees. And while genomic imprinting has long been known to favor chromosomes in plants and loci in mammals, bumble-bee research from the University of Leicester came across another honeypot of epigenetic theories. Other […]

EpiGenie Book Reviews: Epigenetics by L. Armstrong

March 14, 2014

After working on some of the UK’s first embryonic stem cells and developing the world’s first cloned human embryos, Lyle Armstrong turned his attention to the creation of a useful text that would benefit the epigenetic novice as well as the seasoned investigator. With a number of groovy figures and illustrations, they key concepts of […]

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