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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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In Search of 5-hmC’s Tissue Whereabouts

June 16, 2011

5-hydroxymethylcytosine (5-hmC) has been hiding out in the genomic shadows too long, but now researchers armed with a new technique, can track 5-hmC not just to the specific tissue it’s holed up in, but also the developmental stage as well. Or as Martha and the Vandellas put it, there’s “nowhere to run to, baby, nowhere […]

Foursome of DNA Methylation Subgroups Found in Colorectal Cancer

June 16, 2011

As if one kind of colorectal cancer (CRC) isn’t bad enough, new research has uncovered four DNA methylation-based versions of the insidious disease. Our So-Cal neighbors, Toshinori Hinoue and Daniel Weisenberger and team over at the USC Epigenome Center cranked out genome-scale DNA methylation profiles for 125 colorectal tumor and 29 normal tissue samples. The […]

DNA and Histone H3K9 Methylation Often Work Alone

June 14, 2011

Nature is a master of using specific tools for specific jobs, so it’s not too surprising that DNA methylation and SETDB1/H3K9 methylation work on different sets of genes, as University of British Columbia researchers report. But occasionally those tools are more like a Swiss Army knife, like SETDB1, which also methylates H3K9s near endogenous retroviruses […]

Meet LinDA: Single tube ChIP DNA Amplification

June 10, 2011

In the movies, it’s never a problem for CSI techs to get DNA information from the tiniest speck of blood or a just few skin cells. But, for real researchers trying to figure out where transcription factors bind or what’s going on with histones, things are a little harder. That’s why researchers in France, China, […]

CpG Island (R)Evolution

June 2, 2011

CpG islands and their methylation patterns are the epigeneticists bread and butter, and it’s been assumed by many that there are evolutionary reasons behind their existence. New data suggests that not all CpG islands were created equal, and much like Donald Trump’s hair, can’t entirely be explained by natural selection. High-powered researchers from the Weizmann […]

Posttraumatic Stress Risk Altered by DNA Methylation

June 1, 2011

After nearly a decade of sending troops into harms way, the U.S. is now coping with the aftermath that those situations can create for our armed forces, like posttraumatic stress disorder (PTSD). So it’s nice to see progress made towards understanding that condition. While many people are exposed to traumatic events, only a fraction will develop […]

EpiGenie 5-hmC Round-up

June 1, 2011

We’re not entirely sure what the enigmatic base variant 5-hydroxymethylcytosine (5-hmC) does or why it’s important yet, but we do know it’s become one of our favorite epigenetic topics. Whether you’re a 5-hmC newbie, or just need a quick refresher, you’ll want to check out our favorite articles we’ve featured on the subject. Hydroxymethylcytosine Shakes […]

Histone Tails Take the Lead In De Novo Methylation

May 29, 2011

“Newborn” (or de novo) DNA sequences come into this world just like newborn human babies—naked. So, how do new sequences get their DNA methylation on? Researchers from the Chinese Academy of Sciences say they’ve figured out what happens after the histones settle in: H3 tails that lack methylation at K4 bind to and activate de […]

ATP-Dependent Factors Help Nucleosomes Get Organized

May 19, 2011

Those of us with messy desks or bench spaces know how difficult it can be to get organized. But don’t feel bad–a new paper in Science suggests that nucleosomes need help from “professional organizers” to form nice, evenly spaced arrays in gene promoters. For decades now, researchers have been trying to figure out how nucleosomes […]

Methylome Analysis Today: No One is Perfect

May 18, 2011

With everyone focused on their own daily grind, its easy to gloss over some of life’s more philosophical questions like: “Does a falling tree make a sound if no one is there to hear it?” “What is the sound of one hand clapping?” or even “Are my methylome studies really accurate?” In an Epigenomics review […]

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