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ATP-Dependent Factors Help Nucleosomes Get Organized

May 19, 2011

Those of us with messy desks or bench spaces know how difficult it can be to get organized. But don’t feel bad–a new paper in Science suggests that nucleosomes need help from “professional organizers” to form nice, evenly spaced arrays in gene promoters. For decades now, researchers have been trying to figure out how nucleosomes […]

Methylome Analysis Today: No One is Perfect

May 18, 2011

With everyone focused on their own daily grind, its easy to gloss over some of life’s more philosophical questions like: “Does a falling tree make a sound if no one is there to hear it?” “What is the sound of one hand clapping?” or even “Are my methylome studies really accurate?” In an Epigenomics review […]

Decoding the Epigenetic Role of Non-coding RNAs

May 18, 2011

About 90% of our genome is transcribed, but only 1-2% of the transcripts encode proteins. So what are all of those non-coding RNAs (ncRNAs) doing? A better question might be: what aren’t they doing? In addition to regulating gene expression at the transcriptional and post-transcriptional levels, ncRNAs play a big part in the control of […]

RNA Immunoprecipitation Comes Of Age

May 17, 2011

RNA Immunoprecipitation (RIP) is growing up. After suffering through some awkward adolescent years, RIP has evolved from its humble beginnings in a few hardcore labs and is now stepping out shadow of its more famous cousin, Chromatin Immunoprecipitation (ChIP). The more mature RIP has been steadily building its fan base too with curious researchers seeking […]

5hmC Analysis Twofer

May 13, 2011

Everybody loves a twofer, and now for the amount of time spent reading a single Nature paper ( or at least this EpiGenie summary), you can learn about two new methods for 5hmC analysis. A clever team of researchers has developed two independent approaches for the genome-wide mapping of 5hmC, neither of which relies on […]

miRNAs: Masters of the Tumor Microenvironment

May 3, 2011

We’ve all heard the slogans about how to lessen our impact on the environment: Reduce, Reuse, Recycle. But, what about the impact of microenvironments on us? Scientists have known for years that tumor growth is supported by the surrounding microenvironment, and now a group of Italian researchers have identified miRNAs as the masters that control […]

Race and Sex Major Players in Global DNA Methylation

May 3, 2011

Lower global DNA methylation levels have been associated with genomic instability and cancer in humans, making it a great potential biomarker in peripheral blood. So scientists took a close look at the factors around global methylation levels and found that race and gender play a huge role. Researchers from Texas and New York measured the […]

Probing Placental Epigenetics

May 3, 2011

Ever since Tom Cruise publicly vowed to eat his newborn’s placenta a few years back, the “afterbirth” organ has gotten a bum rap. But recent evidence suggests that in addition to its long-recognized role in supplying oxygen and nutrients to the growing fetus, the placenta also influences fetal development through epigenetic mechanisms. Now a trio […]

Epigenetic SNPs Behind Not So Positive Feedback Loop in Alcoholism

May 2, 2011

We all like to celebrate here and there. Shoot…EpiGenie’s still recovering from its royal wedding breakfast bash. But most experts will tell you that moderation is key. Now, researchers in Sweden and Australia give us even more reason to heed that advice and avoid going on that next weekend bender—they found that heavy drinking can […]

Tumor Suppressor Methylation is Cause for Cancer Concern

May 2, 2011

Aberrant DNA methylation causes cancer. Wait, didn’t we know this already? Well, not exactly. Association and causation are two very different things. For instance, being smart may be associated with wearing glasses, but the actual cause is a desire to not bump into everything. In order to determine whether aberrant DNA methylation at particular loci […]

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