epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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ncRNAs Pave the Way for Chromatin Remodeling

October 6, 2008

Researchers have been puzzled by the discovery of several-kilobase-long, polyadenylated transcripts that overlap functional coding regions but do not themselves encode proteins. A recent Nature paper by Kouji Hirota, Kunihiro Ohta, and co-workers at the RIKEN Advanced Science Institute (Japan), the University of Tokyo, and Boston College indicates that some of these ncRNAs are transcriptional […]

RNA-Directed DNA deMethylation: An Undiscovered Country in the RNA World?

October 1, 2008

Let’s face it: it’s an RNA world. In addition to RNA’s many genetic, catalytic, and structural roles, the discovery of small non-coding RNAs has unveiled an entire continent of epigenetic functions. Small RNAs act in processes such as mRNA destruction, translational inhibition, and DNA methylation. Now it appears that, at least in plants, small RNAs […]

How’s That For Gratitude: let-7 miRNA Targets Dicer’s Coding Sequence

September 30, 2008

Recent evidence has shown that the let-7 miRNA bites the hand that feeds it . . . and in an unconventional way. By searching for short sequences conserved at the nucleotide level in the coding regions of 17 species, Hilary Coller and co-workers at Princeton University identified three let-7 target sites within the coding sequence […]

DNA Methylation Detection Goes Small Time

September 28, 2008

A sensitive new nanotechnology assay might represent a “quantum leap” in DNA methylation detection. The technique, which was developed by Vasudev Bailey and co-workers at The Johns Hopkins University School of Medicine, uses quantum dots-fluorescent nanocrystals of a semiconductor material-to selectivel detect and quantify minute amounts of methylated DNA. As in methylation-specific PCR (MSP), sample […]

When Inhibitors Become Inhibited: miR 21 Becomes the Prey

September 26, 2008

It turns out that the small but mighty inhibitors of gene expression have an achilles heel and can be served up a taste of their own effect. Qihong Huang, Alexander Deiters, and colleagues at The Wistar Institute, North Carolina State University, and the University of Pennsylvania School of Medicine discovered the first small molecule inhibitor […]

Roadmap Epigenomics

September 25, 2008

If you’re looking to sneak your grant in on the earliest date for the Epigenomics of Human Health and Disease (R01) grant, time is ticking. Applications are being accepted starting this Sunday. That’s the right, the date says September 28th. For those of you looking for additional information, the grant information is listed below, but […]

Allele-Specific Modifications: A Tale of Two Epigenomes

September 24, 2008

It was the best of times, it was the worst of times-one parental allele was transcribing like gangbusters and the other was permanently stalled. Each of us carries a set of genetically distinct chromosomes from mom and dad, and increasing evidence indicates that the two parental genomes also have widespread epigenetic differences. But how can […]

Structural Effects of Histone Methylation

September 24, 2008

The methylation of histones at specific sites has been linked to both transcriptionally active and repressive chromatin. However, the structural basis for these effects has been difficult to study because homogeneous populations of methylated histones were not available for x-ray crystallography. This situation changed recently with the development of a method to introduce modifications such […]

miRNAs: The New Addition to the Biomarker Buffet

September 16, 2008

Human blood serum is cellular buffet of different biological molecules sampled continuously from every tissue of the body. So it’s not surprising that many researchers have attempted to identify biomarkers in serum that reflect a particular physiological or disease state. Most of these potential biomarkers are proteins (important-yes, exciting-not really), but Zvi Bentwich, Ayelet Chajut, […]

The Many Faces of the miRNA-Argonaute Complex

September 16, 2008

Some might recall playing with Mr. Potato Head as a child (or maybe earlier this morning). By sticking different noses, mouths, eyes, shoes, or other accessories on the basic potato head module, you could generate a variety of silly-looking spuds. Similarly, the interaction of different accessory proteins with the miRNA-argonaute complex might determine the fate […]

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