epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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The Long and the Short of It – Long DNMT3A1 Isoform Binds Bivalent Neurodevelopmental Chromatin

May 23, 2022

Sometimes it’s best to get straight to the point, so let’s dive into this study of DNA methyltransferase 3a (DNMT3A) isoforms with variable lengths, which reveals a chromatin interaction domain that regulates bivalent gene expression and supports early postnatal survival in mice! Previous studies that didn’t beat around the bush described how postnatal development requires […]

Epigenetic Editing Approach Causally Connects Adolescent Alcohol Exposure to Psychiatric Disorder Risk

May 23, 2022

The modularity of current epigenetic editing technology allows us to evaluate the causality of connections from multiple angles. Now, epigenetic editing in rats using dCas9 activators and repressors has provided a welcome new perspective on how adolescent drinking can induce the onset of psychiatric conditions in adults. Binge drinking during adolescence (a critical period for […]

NANOG’s Prion-like Behavior Builds Bridges to Pluripotency

May 11, 2022

In both the literal and figurative sense, building bridges can really get you places! Knowing this, genome engineers and epigenetic architects recently created a blueprint demonstrating how a pioneer transcription factor – NANOG – uses prion-like behavior to form gel-like protein condensates that create interstrand DNA “bridges” to reorganize chromatin and clear a rapid path […]

EPIC Technique Infers Gene Expression from Cell-free DNA Fragmentation

May 9, 2022

It’s time to put down that well-thumbed copy of Homer’s Odyssey, as there is a new epic in town. Now, the “epigenetic expression inference from cell-free (cf)DNA-sequencing” (EPIC-seq) technique heroically enables gene expression analysis using a process known as “fragmentomics.” Circulating cfDNA comes as nucleosome-associated fragments that reflect the chromatin configuration in the cell of […]

Battling Against the Clock: Epigenetic Age Acceleration Impacts COVID-19 Severity

May 2, 2022

Timing is crucial for many aspects of life, and now, a rather timely study demonstrates that the acceleration of our epigenetic clocks after SARS-CoV-2 infection significantly impacts our risk of suffering severe COVID-19 and post-COVID-19 syndrome (“long COVID”). Previous research has described how older patients suffer from a higher risk of developing severe COVID-19 (independent […]

EpiDamID Contains a Flood of Histone Modification Findings from Single Cells!

May 2, 2022

Lately, we’ve been faced with a veritable torrent of awesome single-cell epigenomics methods; thankfully, the development of a new technique – EpiDamID – promises to easily contain the floods of findings regarding histone modification and gene expression patterns coming from single cells! Previously, a talented team from the lab of Jop Kind (Hubrecht Institute, Utrecht, […]

Cell Surface Protein Profiling Gives Single-cell CUT&Tag a Pro Upgrade

April 25, 2022

Nothing beats a Pro upgrade, and lately, researchers have given CUT&Tag the deluxe treatment. This chromatin profiling method received its first improvements with the releases of scCUT&Tag and then Spatial-CUT&Tag; now, we’ve been treated to a view of the cell surface protein profile in its latest form. A pro team of single-cell explorers from the […]

Single-cell Based DNA Methylation Deconvolution Method Scores Another Goal for Epigenetics

April 25, 2022

You might think you know the leading players in the field of computational epigenetics; however, each new season brings forward a squad of exciting new players eager to prove their worth. Recently, one of these players EpiSCORE-d the goal of extending in silico cell-type deconvolution of human epigenomic data to many tissues. While reference-based cell-type […]

APOE Tips Heterochromatin Balance Towards Stem Cell Senescence and Aging

April 11, 2022

Like a healthy balance between work and play can enhance our day-to-day lives, a new study suggests that stem cells require a healthy epigenetic balance between silent and active chromatin domains to support their ongoing normal functions. More specifically, researchers headed by the well-balanced quartet of Moshi Song, Weiqi Zhang, Jing Qu, and Guang-Hui Liu […]

Has Cannabis Gone Up in Smoke? – Study Links Use to Accelerated Epigenetic Aging

March 31, 2022

Like there is no smoke without fire, another study has linked cannabis use to unwanted epigenetic alterations. We’ve seen that cannabis exposure alters DNA methylation in prenatal mouse brains (influencing subsequent behavior), the sperm of rats and humans (priming an autism spectrum disorder-like profile), and human adult brains (impacting brain function), and now epigenetic aging […]

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Epigenetics and ncRNA Headlines

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