epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Battling Against the Clock: Epigenetic Age Acceleration Impacts COVID-19 Severity

May 2, 2022

Timing is crucial for many aspects of life, and now, a rather timely study demonstrates that the acceleration of our epigenetic clocks after SARS-CoV-2 infection significantly impacts our risk of suffering severe COVID-19 and post-COVID-19 syndrome (“long COVID”). Previous research has described how older patients suffer from a higher risk of developing severe COVID-19 (independent […]

EpiDamID Contains a Flood of Histone Modification Findings from Single Cells!

May 2, 2022

Lately, we’ve been faced with a veritable torrent of awesome single-cell epigenomics methods; thankfully, the development of a new technique – EpiDamID – promises to easily contain the floods of findings regarding histone modification and gene expression patterns coming from single cells! Previously, a talented team from the lab of Jop Kind (Hubrecht Institute, Utrecht, […]

Cell Surface Protein Profiling Gives Single-cell CUT&Tag a Pro Upgrade

April 25, 2022

Nothing beats a Pro upgrade, and lately, researchers have given CUT&Tag the deluxe treatment. This chromatin profiling method received its first improvements with the releases of scCUT&Tag and then Spatial-CUT&Tag; now, we’ve been treated to a view of the cell surface protein profile in its latest form. A pro team of single-cell explorers from the […]

Single-cell Based DNA Methylation Deconvolution Method Scores Another Goal for Epigenetics

April 25, 2022

You might think you know the leading players in the field of computational epigenetics; however, each new season brings forward a squad of exciting new players eager to prove their worth. Recently, one of these players EpiSCORE-d the goal of extending in silico cell-type deconvolution of human epigenomic data to many tissues. While reference-based cell-type […]

APOE Tips Heterochromatin Balance Towards Stem Cell Senescence and Aging

April 11, 2022

Like a healthy balance between work and play can enhance our day-to-day lives, a new study suggests that stem cells require a healthy epigenetic balance between silent and active chromatin domains to support their ongoing normal functions. More specifically, researchers headed by the well-balanced quartet of Moshi Song, Weiqi Zhang, Jing Qu, and Guang-Hui Liu […]

Has Cannabis Gone Up in Smoke? – Study Links Use to Accelerated Epigenetic Aging

March 31, 2022

Like there is no smoke without fire, another study has linked cannabis use to unwanted epigenetic alterations. We’ve seen that cannabis exposure alters DNA methylation in prenatal mouse brains (influencing subsequent behavior), the sperm of rats and humans (priming an autism spectrum disorder-like profile), and human adult brains (impacting brain function), and now epigenetic aging […]

DNA Methylation Provides New Insight into the Missing Heritability of ALS

March 31, 2022

The devastating and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) has an estimated heritability rate of around 50%, suggesting that a considerable portion of disease risk derives from environmental and lifestyle risk factors that can leave their mark on the epigenome. Can DNA methylation analysis provide new insight into the missing heritability of ALS? In […]

Welcome to the Jungle! N4-acetyldeoxycytosine is a Wild New DNA Modification Identified in Plants and Detected in Humans

March 14, 2022

It’s time to welcome a new DNA modification to the epigenetic jungle! A collection of more than seventeen modifications have been spotted in the wilds of genomic DNA; however, only the biological effects of the prevalent 5-methyldeoxycytosine (5mC) (and its oxidated family members), along with N6-methyldeoxyadenosine (6mA) have been explored in any depth. Do other […]

CUT&Tag Launches to the Final Frontier: Spatial Epigenomic Profiling of Histone Modifications

March 14, 2022

Space: the final frontier – CUT&Tag has just voyaged where no next-generation sequencing method has gone before to bring forth spatially-resolved histone modification profiles of intact mouse tissues! An expeditionary force led by Rong Fan (Yale University) combined in situ cleavage under targets and tagmentation (CUT&Tag) chemistry, microfluidic deterministic barcoding, and next-generation sequencing to develop […]

“Is this the real-life? Is this just fantasy?” – CultureAGE Shows How In Vitro Studies Reflect In Vivo Epigenetic Aging

February 21, 2022

Profiling epigenetic aging with in vitro cell models may allow for a deeper understanding of the difficult-to-decipher in vivo process, but only if one truly reflects the other; this leaves us wondering: “Is this the real-life? Is this just fantasy?” In their epigenetic rock opera, bohemians from the lab of Morgan Levine (Yale School of […]

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