epigenetics

Epigenetics and ncRNA Headlines

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Mitochondrial tRNAs as Epigenetic Memories of Sperm’s Epididymal Road Trip

June 24, 2024

If Hollywood has taught us anything, it’s that a road trip during our younger years can leave enduring memories that influence our adult lives. Now, a “blockbuster” study reveals that environmental pressures during maturation in the epididymis endow spermatozoa with “epigenetic” memories that influence offspring health via the intergenerational epigenetic inheritance of tRNAs. Researchers “driven” […]

DNA Methylation Differences in Imprinting Control Regions Contribute to Ethnic Disparities in Alzheimer’s Disease Risk

May 28, 2024

Non-Hispanic Black (NHB) patients have a two-fold higher risk of developing Alzheimer’s disease than non-Hispanic White (NHW) patients for unknown reasons; now, a fascinating epigenetics study reveals the involvement of DNA methylation at imprinting control regions (ICRs). Researchers headed by Randy L. Jirtle and Cathrine Hoyo (North Carolina State University) explored ethnic variation in disease […]

G4-DNA: How an Unforgettable DNA Structure Regulates Gene Expression and Memory

May 28, 2024

The Eiffel Tower may live long in the memory, and La Sagrada Familia will be remembered for eons (when they finish it!), but can any structure truly rival DNA? Now, a new study describes how one of DNA’s many unforgettablestructural forms – G-quadruplex DNA (G4-DNA) – helps to regulate the gene expression profiles controlling fear […]

eBook: DNA Methylation 2024

May 15, 2024

DNA methylation, whether in cells or in a cell-free environment, is one of the most powerful and most studied epigenetic regulators of gene expression and genomic organization. This is true for nearly all organisms, leading to the emergence of numerous methods for mapping 5-mC and 5-hmC and other modification states. There are many approaches for […]

Epigenetics Alone Can Drive Cancer—No Mutations Needed

May 13, 2024

Epigenetics has moved into the driver’s seat. In a first-of-its-kind study, a talented team show that knocking down polycomb group proteins in Drosophila causes tumors to form, and bringing the proteins back doesn’t fix it. The finding demonstrates that transient epigenetic changes can irreversibly drive cancer—without genetic mutations. Although we’ve suspected that epigenetic mechanisms could take […]

The Force is Strong with Histone H1.0: How Extracellular Stress Regulates Cell Mechanics through Chromatin Structure

May 6, 2024

Scientists have longed to use “The Force” – provided by intracellular entities known as midichlorians – to help around the lab; now, an epigenetic alliance reports that an intracellular fibroblast component – Histone H1.0 – uses The Force and orchestrates cell mechanics when facing Sith-like evils such as physical/chemical stressors. The force is strong with […]

Pregnancy Epigenetically Ages Mothers – But Breastfeeding May Reverse It

April 22, 2024

Our mothers might be onto something when they jokingly blame us for their gray hair and wrinkles. In two recent studies, DNA methylation-based epigenetic clocks show that pregnancy, with its far-ranging emotional and physical changes, increases the biological ages of mothers. On the bright side, the effects were reversible in those who breastfed, according to […]

This is Your Epigenetic Wake Up Call! Don’t Sleep on NAP-seq When Searching for ncRNAs

April 21, 2024

Has searching for ncRNAs left you needing forty winks? Maybe take a short rest and dream-a-little-dream, but don’t sleep on a brand new technique known as napRNA sequencing or NAP-seq, which represents a wake-up call to the epigenetics field by providing the ability to describe novel classes of human regulatory non-coding or ncRNAs! Wakey-wakey! RNA […]

A Selfish, Poisonous Element Could Set the Evolutionary Stage for Genomic Imprinting

April 15, 2024

A selfish toddler might throw a tantrum to get their way, but in worms, a “selfish” piece of DNA known as a toxin-antidote (TA) element uses something more sinister—poison. Researchers have just discovered a parent-of-origin effect with this nematode element that could be an evolutionary precursor of genomic imprinting. Led by Alejandro Burga (Institute of Molecular […]

EvoETR Epigenome Editor Helps Maintain Cholesterol Levels by Silencing Pcsk9

March 25, 2024

Ever wanted to cut a bad thing out of your life? Well, perhaps the secret to success doesn’t involve any cutting (of your DNA). In some people, a mutant PCSK9 gene interferes with the liver’s job to get rid of LDL, aka “bad” cholesterol. Now, researchers have developed an all-in-one “evolved engineered transcriptional repressor” (EvoETR) […]

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