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Epigenetics and ncRNA Headlines

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Activity Matters: Enhancing our Understanding of Brain Maturation

September 29, 2020

While epigenetic studies have shown us that the past sculpts the future, the mechanisms have remained a cognitive conundrum, particularly when it comes the developing brain. Thankfully, a stimulating new study has come forth to show how early-life brain activity flips a switch that establishes cell-type specific enhancers for life. To prime our brains with this […]

The One With All The Brand New Methylation Factors

September 22, 2020

Could there BE anymore genes affecting DNA methylation? Actually, yes! We always hear about the main cast of the methylation show, the DNMTs and the TETs, but where are all the supporting actors that attract, repel or otherwise interact with these stars? A new show (study) from the studio (lab) of Bastiaan Heijmans (Leiden University […]

C.elegans Studies Worm into the Fundamentals of Transgenerational Epigenetic Inheritance

September 21, 2020

While a “bird’s-eye view” of a topic can often provide colossal insight, the opposite perspective can sometimes be just as useful! Recently, two fascinating studies of transgenerational epigenetic inheritance have taken a “worm’s-eye view” of this research area to deepen our understanding of this complex mechanism in the model nematode worm C. elegans. C. elegans […]

TET2 Overtrims the Methylation Hedges at Enhancers in Parkinson’s Disease Neurons

August 25, 2020

It takes real restraint to prevent a routine hedge trim from turning into a horticultural horror show; and like an overzealous landscaper, new research shows that TET2 may be mowing down the methylome in Parkinson’s Disease (PD) neurons. The cognitive and motor symptoms of PD are caused by the degeneration of dopamine-producing neurons in the […]

Epitranscriptomic tRNA Study Finally Reveals the “Y” of Aggressive Colon Tumors

August 25, 2020

Away with you Holmes, begone Poirot, and bye-bye Nancy Drew, because a terrific team of epigenetic detectives has solved an epitranscriptomic cold case to reveal the “Y” of aggressive colon tumors by linking CpG island promoter DNA hypermethylation of a key epitranscriptomic modifier and a transfer RNA (tRNA) modification to tumorigenesis. Epitranscriptomics includes the modification […]

Exosomal microRNA Roots for Regrowth by Raising Hairs in Retired Follicles

August 15, 2020

Move over, Rogaine; the pharmacies of the future will carry hair regrowth treatments that contain microRNAs from hair follicle exosomes! There are creams, supplements, lasers and even surgery, but people struggling with hair loss still don’t have a convenient and effective treatment to help them restore their luscious locks. New treatments could involve injecting dermal […]

Cutting Through the Smog of Mitochondrial DNA Methylation after Prenatal Pollution Exposure

August 7, 2020

While everyone loves hearing about a scientific controversy, clearing the air can also provide a sense of satisfaction. So, sit back and take a breath of the fresh air that an environmentally conscious team brings to the controversy surrounding mitochondrial (mt)DNA methylation through their examination of prenatal exposure to environmental stressors such as air pollution […]

Expand Your Epigenetic Editing Portfolio With Targeted RNA m6A Methyltransferases!

August 4, 2020

For the last few years, DNA has cornered the methylation market as the Apple of epigenome editing tools, but a newly developed CRISPR-Cas13 system has epigenetic investors buying stock in RNA editing! 6-methyladenosine (m6A) is the most abundant RNA modification, and even though we know it’s involved in chromatin accessibility, RNA splicing and repairing damaged […]

Exon Skipping via Intergenerational Epigenetic Silencing Rescues Duchenne Muscular Dystrophy

July 29, 2020

While missing a gym class can happen from time to time without leaving you feeling too guilty (!), you really shouldn’t “skip” a fascinating new study that now describes how a maternally-transmitted epigenetic “exon skipping” effect may act as the foundation for new therapeutic approaches for a devastating genetic muscle-weakening disease. A majority of Duchenne […]

rChIP-Seq Ratifies RNA as a Requirement for PRC2 to Rock and Roll

July 20, 2020

Once in a while, an epigenetic technique comes along to rock your world more than your favorite Led Zeppelin or Foo Fighters album! Now, a band of researchers fronted by the dynamic duo of John L. Rinn and Thomas R. Cech (University of Colorado, Boulder, CO, USA) has just released a chart-topping masterpiece with their […]

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Epigenetics and ncRNA Headlines

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