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Epigenetics and ncRNA Headlines

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Cutting Through the Smog of Mitochondrial DNA Methylation after Prenatal Pollution Exposure

August 7, 2020

While everyone loves hearing about a scientific controversy, clearing the air can also provide a sense of satisfaction. So, sit back and take a breath of the fresh air that an environmentally conscious team brings to the controversy surrounding mitochondrial (mt)DNA methylation through their examination of prenatal exposure to environmental stressors such as air pollution […]

Expand Your Epigenetic Editing Portfolio With Targeted RNA m6A Methyltransferases!

August 4, 2020

For the last few years, DNA has cornered the methylation market as the Apple of epigenome editing tools, but a newly developed CRISPR-Cas13 system has epigenetic investors buying stock in RNA editing! 6-methyladenosine (m6A) is the most abundant RNA modification, and even though we know it’s involved in chromatin accessibility, RNA splicing and repairing damaged […]

Exon Skipping via Intergenerational Epigenetic Silencing Rescues Duchenne Muscular Dystrophy

July 29, 2020

While missing a gym class can happen from time to time without leaving you feeling too guilty (!), you really shouldn’t “skip” a fascinating new study that now describes how a maternally-transmitted epigenetic “exon skipping” effect may act as the foundation for new therapeutic approaches for a devastating genetic muscle-weakening disease. A majority of Duchenne […]

rChIP-Seq Ratifies RNA as a Requirement for PRC2 to Rock and Roll

July 20, 2020

Once in a while, an epigenetic technique comes along to rock your world more than your favorite Led Zeppelin or Foo Fighters album! Now, a band of researchers fronted by the dynamic duo of John L. Rinn and Thomas R. Cech (University of Colorado, Boulder, CO, USA) has just released a chart-topping masterpiece with their […]

H4K16ac Marks an Intergenerational To-Do List for Developing Fly Embryos

July 7, 2020

Do the laundry? Check. Buy fabric softener? Got it. Write that next manuscript? Working on it… We’ve all got a lot on our to-do lists these days, but it’s nothing compared to the checklist that developing drosophila embryos have to contend with. On top of coordinating histone methylation marks, they’ve got to prepare for a […]

Disrupted LADs Drive Epigenetic Alterations in Human Early-onset Aging

June 22, 2020

The “driver” represents a crucial part of a successful Formula One team, a decent score at golf, and even a well-planned bank heist (!), and working out those factors that drive the onset of various diseases and disorders may provide critical mechanistic insight and even aid the development of novel therapeutic approaches. In the early-onset […]

Epigenetic Hole-in-One: Methylation of a Single CpG Disrupts GATA-1 Binding and Regulates Gene Expression

June 11, 2020

The GATA-1 transcription factor is like the Tiger Woods of the erythroid cell lineage, topping the leaderboard and driving the expression of important developmental genes. Other molecular competitors, like the NuRD complex, are already on the course, but a new study shows how methylation of a single CpG is able to score a hole-in-one to […]

Dynamic Modeling of DNA Methylation “Turnover” Reveals Tasty Epigenetic Morsels

June 11, 2020

While the word “turnover” may send the culinary-minded to the kitchen and the business-savvy straight to the accounts books, epigeneticists studying the turnover of DNA methylation have been left between a rock and a hard place! Researchers are in this unappetizing predicament as while we can accurately paint a genome-wide picture of DNA methylation levels, […]

Transgenerational Epigenetic Inheritance in Worms is A “Tail” of Two Nucleotides

June 2, 2020

While the sprawls of London and Paris take center stage in the novel “A Tale of Two Cities,” we now seek to narrate an alternative epigenetic “tail” that tells all about two nucleotides! In this hefty tome, uridine and guanosine play the starring roles in a story passed down through generations and generations of worms; […]

A Rewired Metabolism Links the Aging Epigenome to Vision Loss

May 16, 2020

They say hindsight is 20/20, but for those of us looking over at a lifetime of memories, things might seem a little blurrier through our aging eyes. That’s because, unlike the fine wines, delectable whiskies, and smelly cheeses that we love to catabolize, the human epigenome tends not to age very well and a wide […]

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Epigenetics and ncRNA Headlines

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