epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Databases for Epigeneticists

December 13, 2011

The holidays have come a little early for epigeneticists! Nucleic Acids Research just published papers on several databases that put a wealth of information on various epi-phenomena right at your fingertips. Chances are, at least one of these has info that will make your research life a whole lot easier. HIstome The Histone Infobase (HIstome), […]

Profiling Exon Methylation with Liquid Hybridization Capture-Based Bisulfite Sequencing

December 12, 2011

Sometimes, you just want to get to the good stuff right away. Now, researchers in China report that they’ve developed a way to target their sequencing when analyzing methylomes rather juggling 6 hard drives. With their new liquid hybridization capture-based bisulfite sequencing (LHC-BS) method, they just grab exons and analyze them for methylation. The method […]

EpiGenie Review: Non-coding RNAs and miRNAs in Cancer

December 9, 2011

Based on the latest research, the cancer::non-coding RNA conncection is undeniable. It’s just all the specifics around things like miRNA regulation that are still left to be understood. While dedicated epigenetics investigators are hard at work solving those mechanistic riddles, we’ve decided to take a look back at what’s been learned so far. Here are […]

Hypermethylated Pockets within Hypomethylated Genomic Regions Defines Cancer Cells

December 5, 2011

What makes a cell become a cancerous? We’d all love to know that, right? Well, new research has gotten a little bit closer to figuring out key epigenetic differences between cancer and normal genomes. It turns out that the DNA methylation patterns of these cells differ drastically, no surprise there, but it’s the genomic context […]

Get Captivating Performance with Zymo’s Genome-wide 5-hmC Analysis Service

November 29, 2011

The interest in 5-hydroxymethylcytosine (5-hmC) seems to be increasing faster than the national debt, but there still aren’t many tools available to aid scientists in understanding the 6th base, especially in a genome-wide context. Most current antibody and IP-based approaches are useful but can be a little difficult when applied to NGS. Fortunately, the methylation […]

EpiGenie Review: DNA Methylation in Cancer

November 28, 2011

DNA Methylation definitely has a major role in cancer, but with the all of the different tissue types and cancer variations, it’s been nearly impossible to define exactly what that role is. That hasn’t stopped dedicated researchers from chipping away at the task, though…or EpiGenie from covering it. Check out the advances in understanding DNAm […]

Chromatin Altering Enhancers Help Genes Escape lncRNA Silencing

November 23, 2011

This holiday season, you may not be able to escape the big family dinner table, and the aunts and uncles that drink too much and bring up old arguments. But researchers at Temple University report that some genes can escape from the stranglehold of silencing that long noncoding RNAs (lncRNAs) impose. And they do it […]

Human Mitochondria Have Long Noncoding RNAs Too

November 20, 2011

Mitochondria are the powerhouses of the cell, but even though they supply critical energy to keep everything else running, genome researchers often ignore them. Hey, mitochondria have genomes, too! What do they have to do for attention, stage an “Occupy Cell” demonstration? Now that researchers in Australia have discovered long noncoding RNAs (lncRNAs) in human […]

Neuronal Histone Modifications in Autism

November 15, 2011

Autism spectrum disorders (ASD) are mostly seen as a range of mental conditions, so researchers from the University of Massachusetts Medical School focused in on the prefrontal cortex (PFC) neurons of autistic individuals, and mapped their H3K4me3 epigenomes in order to better understand the complex condition. The project compared autistic PFC neuron profiles to a […]

Socio-Economic Status Leaves A Methyl Mark on DNA

November 9, 2011

Candidates for public office never seem to learn that you can’t escape your past. It’s almost like they’ve never even heard of Google or YouTube or something! Speaking of not letting go of the past, we’ve seen a few papers recently suggesting that some epigenetic changes in early life can stick around for decades. Now, […]