epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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This Hi-Def Methylation Experience is Brought to You by Bisulfite Capture

July 15, 2009

Even if you don’t have a new flat screen HD TV hanging in your living room, most of us have at least seen the beauty that is HD when strolling through the TV section in the local Wal-Mart or Best Buy. The picture is so crystal-clear that watching a game in HD is just like […]

miBridge: Bringing mRNA UTRs Together

July 9, 2009

When it comes to the the miRNA translational repression model, 5’ UTRs have been neglected more than California’s budget deficit in recent years. Despite computational approaches predicting oodles of miRNA docking sites for miRNAs in the 5’ UTR, we haven’t seen that many studies tackle the other side of miRNA repression. But just a few […]

Differentiation Got Your Chromatin in a Bind?

July 8, 2009

Euchromatin could be what gives stem cells their stemness. A screen for factors that both reduce embryonic stem (ES) cells’ ability to expand and diminish their expression of stem cell marker Oct4 yielded just one that hadn’t been seen before: the chromatin-remodeling enzyme Chd1. Chd1 recognizes di-or tri-methylated histone 3 at lysine 4 (H3K4me2/3) – […]

Want Smooth Muscle? You’ll Need Some miR-145

July 8, 2009

OK, maybe you won’t find a bottle of miR-145 at the juice bar of your local gym anytime soon, but a paper published recently in Nature says that miR-145 is all you really need to turn mouse cardiac progenitor cells into smooth muscle. What’s more, both miR-145 and miR-143 team up to regulate a smooth […]

Wounds Make Polycomb Group Proteins (PcGs) Skedaddle

July 7, 2009

Ouch! Skinned knees and paper cuts are a fact of life—we’ve certainly had our share. But we’d never wondered what was going on in those wounds, unlike Paul Martin and Tanya Shaw at the University of Bristol. They have realized that wound healing is similar to embryogenesis, a process in which epigenetic mods are commonplace. […]

DNA Methylation and HIV Latency

July 1, 2009

You’d think keeping HIV from replicating was a good thing, and it is … unless you’re trying to eradicate the virus. One of the world’s most elusive viruses is an expert at maintaining a low profile, laying dormant in CD4+ cells even during highly active anti-retroviral treatment (HAART). A team of American and Swedish researchers […]

HIV’s RISC-y Behavior

July 1, 2009

There’s nothing restricting miRNAs to targeting just endogenous mRNAs. So it’s no surprise to find that expression of miR-29a – which targets the 3’UTR of HIV-1 mRNA — increases during HIV infection. Researchers from U Mass Med School in Worchester, and the Burnham Institute for Medical Research in La Jolla, found that HIV mRNA hangs […]

Erring on the Side of Calling: Sequencing Mismatches Highlight RNA Editing

July 1, 2009

To err is enzymatic; to identify errors previously thought to be technical, but are actually biologically relevant, is divine. Most researchers view the sequencing errors from reverse transcription, sequencing reaction, or base calling part of the job. After all, with the mountains of sequence pouring off these platforms, one would expect and accept a few […]

Don’t Go Away Mad (Just GOmir)

July 1, 2009

Figuring out the targets of your favorite miRNA is no simple matter, and if it ranks somewhere between cleaning the bathroom and a trip to the dentist on your list, then you’ll want to check out a new java-based tool called GOmir which makes the miRNA target analysis experience a little less painful. A group […]

Lincd In: Large Intervening Non-Coding RNAs Expand their Networks

June 25, 2009

Last February, a team of standouts from the publication factory in Boston (aka Broad Institute), published work highlighting over 1,500 previously un-annotated genomic sequences that housed large intervening non-coding RNAs known as lincRNAs. These transcripts showed similar expression patterns as mRNA and they exhibited more conservation than neutral sequences, indicating they were probably functional, but […]

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