epigenetics

Epigenetics and ncRNA Headlines

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Stressed Out Moms Methylate

March 1, 2011

Raising babies is a stressful thing, made even more so when Mom herself is raised: a meter high on a Plexiglas platform, while she’s pregnant, that is. The effect on her kids – er, pups – is manifest in brain and body weight, in behavioral development, and even epigenetically. Researchers from the University of Lethbridge […]

miRNPs Offer Support to miRNA Seeds

February 28, 2011

Everyone appreciates a little extra support now and then, and a new study shows that miRNAs, or more specifically their seed regions, do too. The report in NAR uncovered that micro-ribonucleoprotein complexes (miRNPs) get miRNAs ready to take care of their mRNA targeting business by shoring up the structure of miRNA seed regions, which is […]

Turning Back the Clock: Epigenetics, iPSCs and Aging

February 25, 2011

Aging can be a real downer, but for some individuals premature aging is a lot more serious than a few aches and pains the morning after some touch football. Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal genetic disorder where the victims speed through aging. It is caused by a point mutation in the […]

5-mC Stabilizes High-Maintenance Methyltransferases

February 16, 2011

Many things in life–like diets, exercise routines, and blogs–are easier to start than maintain. The same can be said for DNA methylation. De novo methyltransferases establish DNA methylation patterns in embryonic stem cells, but exactly how somatic cells maintain these patterns is puzzling. Now researchers at the University of Southern California have identified a new […]

Cocaine Keeps the LINEs Jumping

February 16, 2011

New research surfacing in PNAS details the downward spiral cocaine induces in heterochromatin in the reward center of our brains. Over the years researchers have found that cocaine can regulate chromatin structure in the nucleus accumbens, a reward region in the brain and an area closely tied to addiction. DNA methylation machinery has also been […]

CoSBI Squeezes More Data From Histone Maps

February 14, 2011

As the ‘histone code’ hypothesis gains steam, it’s become obvious that there isn’t much out there to help the chromatin research community look for combinatorial relationships between histone modifications. That’s where the Coherent and Shifted Bicluster Identification (CoSBI) algorithm comes in; to help wring even more data from genome wide histone mod maps. Not to […]

Genome-Wide Methylation Sequencing Hits the Fast Lane

February 11, 2011

Genome-wide DNA methylation sequencing hasn’t been much more than sci-fi reading for most labs. Sure there’ve been some great papers with really slick technologies, but many researchers just don’t have access to them. In many cases, no single lab can handle the complete experimental workflow from sample prep to data management/analysis, requiring collaborations with other […]

MethylC-Seq Delivers First Single Base Resolution Methylation Profiles of iPSCs

February 2, 2011

There’s always something a bit “off” when you look at aging starlets who’ve had some work done. In the same way, researchers in California and Wisconsin recently found that induced pluripotent stem cells (iPSCs) generated from old somatic cells aren’t quite the same as youthful embryonic stem cells (ESCs)—the epigenetics are “off”. Sure, iPSCs and […]

Watch It: Sensitive 5-hmC Detection in Action

February 1, 2011

Hockey, Nascar, 5-hmC analysis…. Somethings are just better experienced in person. So if you’re in the market for pinning down 5-hmC in your studies, you’ll want to check out this short JOVE vid that show’s NEB’s EpiMark™ 5-hmC and 5-mC Analysis Kit tracking down 5-hydroxymethylcytosine levels in mouse Babl/C brain. Watch Video Click to view […]

Take a Bite Out of Cancer with the Epigenetics Diet

February 1, 2011

What’s your idea of a perfect meal? Whether you’re into the In-N-Out burger, fries, and milkshake trifecta, or you’re more of a “cleanse” type, the epigenetics enthusiast in you will be interested in a recent review by Trygve Tollefsbol and colleagues that reveals that certain foods contain ingredients that may prevent and treat cancer. Although […]

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