epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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No Epigenetic Modification is an Island: How Reader Proteins Functionally Interpret Complex Chromatin States

March 25, 2024

Like no man is an island and instead relies on those surrounding them, single epigenetic modifications generally do not function in solitary. Now, an absorbing new study from a synergistic epigenomics squad reports how epigenetic reader proteins functionally interpret chromatin states made up of complex combinations of disparate epigenetic modifications. A highly collaborative team guided […]

Gut Microbiota Uses the Histone Code to Make Intestinal Cells Speak Their Language

March 19, 2024

A growling stomach represents a clear sign that you must eat something tasty; however, sometimes, your digestive system is where the message needs to go! An exciting epigenetics study reveals that our gut microbiota employs a histone code via histone acylations to influence gene expression in intestinal cells, forcing these cells to speak their language! […]

reChIP Doubles Down on Low-input Profiling of Bivalent Chromatin

March 5, 2024

Sometimes, when you’re dealt the right hand, doubling down is a sound strategy. Although it can be a risky move in blackjack, a new ChIP-seq method makes it a sure thing when you’re dealing with bivalent chromatin. The strategy, which includes important preparation steps and two rounds of chromatin immunoprecipitation (ChIP), provides sensitive genome-wide profiles […]

Updated cfDNA Nucleosomics Technology Upgrades our Epigenetic Clocks

March 4, 2024

A new style, novel functionalities, and a better overall product; we always want our smartwatches to employ the latest technology, and why not?! Now, a well-timed update involving cell-free DNA (cfDNA) nucleosomics-based technology provides for a significantly upgraded epigenetic clock, which may boost aging-based research. A punctual team led by Vladimir B. Teif (University of […]

FORGEdb Deciphers Genetic Variants and Disease Mechanisms to Tell Whether Your Gene Regulation Mechanism is a Touchdown or a Field Goal!

February 26, 2024

Performing experiments to understand gene regulation and do not want to miss any extra points? Well, FORGEdb may be the method for you! Building on previous research, this new method can help scientists unravel the mysteries behind complex diseases by identifying candidate functional variants and uncovering target genes and mechanisms. Developed by a team led […]

SIMPLE-seq Collaborates Chemistries to Report Single-Cell 5mC and 5hmC

February 20, 2024

Collaborations work best when team members’ abilities complement each other. That’s what makes SIMPLE-seq work so well—it’s a simple, easy combination of two methods that complement each other to provide both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) datasets in one experiment in single cells and molecules. Continuing on the recent theme of methods that report both 5mC […]

Relax and Let NanoSPA Analyze m6A and Ψ RNA Mods for You

February 20, 2024

We could all use a spa day once in a while, so light some lavender-scented candles, take a deep breath, and let NanoSPA analyze the RNA modifications in your samples. This new nanopore sequencing analysis pipeline provides data on both N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications at the same time, reducing stress and saving time. Instead […]

Making a Connection – Lactate Epigenetically Links Metabolism and Gene Expression

February 19, 2024

Falling in love, kicking a football, and cell identity changes driven by metabolic reprogramming all have one thing in common – making a connection is vitally important! Now, a well-hooked-up new study reveals how lactate epigenetically links metabolism to the activation of a gene regulatory network that controls embryonic development. A plugged-in team of researchers […]

TIME-Seq Flies When Constructing Cost-Effective Epigenetic Clocks

February 19, 2024

If time drags and money disappears when looking at DNA methylation-based epigenetic clocks, you are “in time” to hear of a newly described efficient and cost-effective bisulfite sequencing approach! Time flies – but money does not – with “tagmentation-based indexing for methylation sequencing” or TIME-seq! An on-time team led by David A. Sinclair (Harvard Medical […]

eBook: New & Novel Methods for Epigenetic Analysis

February 7, 2024

Epigenetics is not new, but methods used for analysis certainly can be! In this eBook, we take a look at, and present in a simple format, some of the hottest new methods for researchers looking at DNA Methylation, RNA modifications, Chromatin and Gene Regulation. Topics Include: Differential Methylation Data Are Quick, Easy, and Inexpensive with […]

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Epigenetics and ncRNA Headlines

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