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Epigenetics and ncRNA Headlines

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Mapping mRNA Methylation in the Mouse: From ESCs to the Brain

January 23, 2017

As Ptolemy and other noteworthy cartographers will tell you, a detailed and up-to-date map is always useful. This navigational tool has guided many intrepid explorers from familiar regions towards the unknown with the promise of discovery and adventure! In the linear world of ribonucleic acid (RNA), intrepid researchers have mapped the locations of the N6-methyladenosine […]

RICC-seq Uses Gamma Rays to Smash out Nucleosome-Nucleosome Interactions

January 17, 2017

Gamma rays can give super powers to scientific insight, whether it be PET scans, the Epigenetic Hulk, or nucleosome-nucleosome interactions. While we’ve seen a lot about the primary structure of single nucleosomes and the tertiary structure of large chromatin loops, it seems that the 1–3 nucleosome (50–500 bp) architecture known as secondary structure has been […]

Copy Number Variation and Environmental Exposure Unwrap the DNA Methylation Storage Box of Autism

December 29, 2016

Preparing for a big event takes a lot of work; whether it be the holidays or developing a brain’s epigenome, keeping a storage box ready to go for the situation just makes sense. In their latest publication, the lab of Janine LaSalle at the University of California – Davis unwrap the epigenetic storage box of […]

dCas9-Dnmt3a-Dnmt3L Methyltransferase Seeds a Nuclear Reaction

December 15, 2016

Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]

Frequently Interacting REgions (FIREs) Ignite Chromatin’s Promiscuity

December 10, 2016

Once thought to be monogamous molecules characterized by devote linear relationships, chromosomes turn out to be philandering conformation-changers with burning loins of desire concealed between their genes. Coming from the lab of Bing Ren at the University of California, San Diego, a massive analysis of genome-wide chromosome interactions captured by Hi-C uncovers a distinct piece […]

Microbes and their Metabolites Serve Tasty Tissue Histone Modifications

December 5, 2016

The old adage reads “you are what you eat”, but a tasty new study turned that bland old phrase into “your histones are what you eat!”, and what’s more, those behind the study have worked the mechanistic link. Some of our daily diet (i.e. coffee and candy) acts as an energy and carbon source for […]

ATAC-see Assaults Chromatin from Two Fronts: Visualization and Sequencing

November 24, 2016

After playing hide-and-seq with chromatin for a while, we’re sure you’ve been begging for a new plan of attack to help you see what’s going on. Thankfully, a Northern California collaboration led by the lab of Howard Chang alongside the labs of William Greenleaf, Jan Liphardt, and Jennifer Doudna has brought forth a tactic to […]

Dnmt3C: A New Piece of DNA Methylation Machinery

November 24, 2016

A dog walk in the countryside led to Velcro, the search for chest pain therapies gave us (who me?) Viagra, and a messy microbiology lab bench provided penicillin. Some big research discoveries appear to have arrived in an “accidental” form and maybe, just maybe, new research from the laboratory of Déborah Bourc’his can be spoken […]

SALL4A Sets the Mood for a DNA Demethylation TET-á-TET

November 16, 2016

A romantic “tête-à-tête” between two lovebirds usually involves helping factors which set the mood and make the night move along slickly. A good wine, some soft lighting, and maybe even a little smooth jazz! While that might work for the humble researcher, the “TET-á-TET” involved in DNA demethylation is a slightly different affair and demands […]

The Delicate Balance Between H3K27me2 and H3K27me3 Decides Stem Cell Fate

November 15, 2016

The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27me) via its catalytic subunit Ezh2. While H3K27me3 and H3K27me1 have been associated with gene repression and activation respectively, the exact role of H3K27me2 remains under-explored. However, recent works in temperature-sensitive drosophila and in PRC2 knock out embryonic stem cells (ESCs) suggest a role […]

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