epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Gene Body DNA Methylation Keeps Cells Fit and Healthy

March 9, 2017

Boots, check! Helmet, check! DNA Methylation, check? Any active individual will tell you that protecting your body is an integral part of keeping fit and healthy while enjoying your sport of choice. In the über-competitive world of DNA, a study from the teams of Francesco Neri and Salvatore Oliviero has proposed that DNA methylation on […]

Single and Ready to Mingle: Single-Cell Bisulfite Sequencing Gives Up Its Intimate Secrets

March 9, 2017

Ever fancy a go with a new technique only to find that the methods section of the paper is holding out on the most intimate details? While single-cell bisulfite sequencing (scBs-seq) has been lusted after by many a researcher, mingling with those single cells has proved a bit more challenging. But fear not, the labs […]

Optogenetic Epigenetic Editing of DNA Methylation Puts You in Control of Stem Cell Fate

February 16, 2017

In Greek mythology, the fates forge the strings of life that control our lives and choose the moment of its end. We mere mortals yearn for such powers and we are now one step closer to the light thanks to an optogenetic epigenome editing system that lets you write and erase DNA methylation to control […]

Histone Modification Imaging Pr-EDICTS Stem Cell Fate

January 27, 2017

Will it rain? Will my team win? Will I get that grant? There are instances where a glance into a fortune-teller’s crystal ball could definitely give you the upper hand. Although the crystal ball is a myth, researchers from the lab of Prabhas V. Moghe (Rutgers University, New Jersey, USA) have recently developed a means […]

Mapping mRNA Methylation in the Mouse: From ESCs to the Brain

January 23, 2017

As Ptolemy and other noteworthy cartographers will tell you, a detailed and up-to-date map is always useful. This navigational tool has guided many intrepid explorers from familiar regions towards the unknown with the promise of discovery and adventure! In the linear world of ribonucleic acid (RNA), intrepid researchers have mapped the locations of the N6-methyladenosine […]

RICC-seq Uses Gamma Rays to Smash out Nucleosome-Nucleosome Interactions

January 17, 2017

Gamma rays can give super powers to scientific insight, whether it be PET scans, the Epigenetic Hulk, or nucleosome-nucleosome interactions. While we’ve seen a lot about the primary structure of single nucleosomes and the tertiary structure of large chromatin loops, it seems that the 1–3 nucleosome (50–500 bp) architecture known as secondary structure has been […]

Copy Number Variation and Environmental Exposure Unwrap the DNA Methylation Storage Box of Autism

December 29, 2016

Preparing for a big event takes a lot of work; whether it be the holidays or developing a brain’s epigenome, keeping a storage box ready to go for the situation just makes sense. In their latest publication, the lab of Janine LaSalle at the University of California – Davis unwrap the epigenetic storage box of […]

dCas9-Dnmt3a-Dnmt3L Methyltransferase Seeds a Nuclear Reaction

December 15, 2016

Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]

Frequently Interacting REgions (FIREs) Ignite Chromatin’s Promiscuity

December 10, 2016

Once thought to be monogamous molecules characterized by devote linear relationships, chromosomes turn out to be philandering conformation-changers with burning loins of desire concealed between their genes. Coming from the lab of Bing Ren at the University of California, San Diego, a massive analysis of genome-wide chromosome interactions captured by Hi-C uncovers a distinct piece […]

Microbes and their Metabolites Serve Tasty Tissue Histone Modifications

December 5, 2016

The old adage reads “you are what you eat”, but a tasty new study turned that bland old phrase into “your histones are what you eat!”, and what’s more, those behind the study have worked the mechanistic link. Some of our daily diet (i.e. coffee and candy) acts as an energy and carbon source for […]

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