epigenetics

Epigenetics and ncRNA Headlines

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Evasive Maneuvers! LINE-1 at the Helm Outwits Epigenetic Repression

July 16, 2019

While the above title may conjure up images of Star Wars-esque galactic battles, the epic clash between the LINE-1 (L1) retrotransposon and repressive forces takes place on the scale of microns instead. This war has been waging in the human genome for thousands of years: L1 attempts to replicate and integrate into the genome, while […]

Shifting Sex: Social Stress Throws Epigenetics in Reverse for Female Bluehead Wrasses

July 15, 2019

Have you ever run into an unexpected detour on your commute? Whether it be an ice patch, flood, or even a mudslide, mother nature can reroute even the best laid plans, but for some species, changes in the environment have much higher stakes than being late for work or that much needed vacation. In fact, […]

Mitochondrial Memes: How the Powerhouse of the Cell also Drives Epigenomic Alterations

July 12, 2019

The appreciation of the mitochondrion as “the powerhouse of the cell” has become as culturally pervasive as some of our favorite memes; however, a powerful new study now shows that signals deriving from this double-membrane-bound ATP-generating organelle represent a major driving force behind alterations to the epigenome. A talented team of researchers from the lab […]

Epigenetic Heirlooms: The C. elegans Behavioral Legacy is Inherited Through Small RNAs

July 2, 2019

Some families have heirlooms that get passed down from generation to generation but if you’re a nematode, you might inherit more than just your Grandpa’s pocket watch! The phenomenon of transgenerational epigenetic inheritance (TEI) was first discovered in Caenorhabditis elegans, where environmental stressors can alter physiological responses in offspring up to 20 generations later! Since […]

Mutant DNMT3A Underperforms in Overgrowth Syndrome

June 25, 2019

If you’re underperforming at work, you might end up with a rejected paper, failed experiments, or an angry boss. However, this isn’t so bad when compared to how mutated DNMT3A underperforms in its role as a DNA methyltransferase, since that can result in a pathogenic overgrowth known as Tatton-Brown-Rahman syndrome (TBRS). Despite DNMT3A’s known role […]

Whole Genome Bisulfite Sequencing of Down Syndrome Brain Captures the Big Picture

June 18, 2019

Sometimes in life, we get so focused on the details that we can miss the big picture. One of the best examples of this periscope perspective is the case of Down syndrome. Although it is caused by trisomy of chromosome 21, Down syndrome patients display genome-wide alterations to their transcriptomic and epigenomic profiles; however, the […]

Enhancer Hypomethylation in Alzheimer’s Disease Brain Paves the Way for Cell Death

June 15, 2019

When it comes to understanding the epigenetics of aging, Alzheimer’s Disease (AD) has enhanced our knowledge in countless ways. This neurodegenerative disease has taught us to embrace healthy aging, and some surprising players have emerged from the examination of DNA methylation. Studies have uncovered a role for enhancers in AD; however, investigations into the consequences of DNA methylation at these […]

Heterochromatin Finds an Alternative Way to Lengthen Telomeres

June 15, 2019

We recently advised our readers to “think different” when it came to the epigenetic control of maintenance in alternative lengthening of telomeres (ALT) cells, and now, a team of “out-of-the-box” thinkers from the lab of Jérôme Déjardin (Université de Montpellier, France) have described an unconventional link between ALT and telomeric heterochromatin formation. Previous results have […]

SETing up SETD2 as a Key Player in Oocyte Development

June 5, 2019

While we’ve been fascinated by how epigenetic alterations during development SET the stage for adult life, in order to fully understand this relationship, we also have to examine how the stage for the development is SET by our epigenome. The epigenome of the oocyte is reprogrammed during early embryonic development; however, some marks remain at […]

The Chicken or the Egg: Beefing Up Causal Relationships Between DNA Methylation and Gene Expression in Skeletal Muscle

June 4, 2019

An age old question: Which came first: the chicken or the egg? Determining the cause and effect relationship isn’t easy, and the same is true for the relationship between DNA methylation (DNAme) and gene expression. Who is strong-arming who? And even more important (at least to the pragmatists among us), how do both of these […]

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Epigenetics and ncRNA Headlines

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