epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Transgenerational Epigenetic Inheritance Timeline

March 17, 2014

Molecular inheritance is what genetics is all about, so here we highlight some examples where the epigenome plays a key role in inheritance.

Histone Acetyltransferase Circumin Eases Neuropathic Pain

March 17, 2014

There’s definitely not much “gain” in Neuropathic Pain, but recently some Histone Acetyltranferases (HATs) have begun to show great promise in the clinic. This includes circumin, which is used to treat a number of conditions like Alzheimer’s, Cancer, Arthritis and Neuropathic Pain. Circumin is a (p300/CREB-binding protein (CBP)) inhibitor of HAT activity, but the biological mechanisms for […]

Bees Join the Genomic Imprinting Hive

March 17, 2014

The buzz had always been that DNA methylation mechanisms appear absent in most insects, but are known to occur in social insects, like bees. And while genomic imprinting has long been known to favor chromosomes in plants and loci in mammals, bumble-bee research from the University of Leicester came across another honeypot of epigenetic theories. Other […]

EpiGenie Book Reviews: Epigenetics by L. Armstrong

March 14, 2014

After working on some of the UK’s first embryonic stem cells and developing the world’s first cloned human embryos, Lyle Armstrong turned his attention to the creation of a useful text that would benefit the epigenetic novice as well as the seasoned investigator. With a number of groovy figures and illustrations, they key concepts of […]

CpG Canyons Join the DNA Methylation Landscape

March 14, 2014

While CpG Islands and CpG Shores have always been hot destinations on the CpG landmark tour, a new feature has emerged that may just give them a run for their money. Using genome-wide mapping of 5mC and 5hmC in mouse stem cells to explore the luxurious shores and islands of the CpGenome, an adventurous team from the Baylor College of […]

Webinar: Whole-genome Insights into Cancer as a Dysregulated Epigenome Allowing Cellular Growth Advantage at the Expense of the Host

March 10, 2014

Dr. Andrew Feinberg discusses recent work that has shed new light on the epigenome and it’s role in cancer. Abstract: We and our collaborators have been developing efforts toward whole genome approaches to epigenetic analysis of human disease, including array-based analysis and whole genome bisulfite sequencing. Surprising results have been the discovery of CpG island shores and large hypomethylated […]

Webinar: Genetic Analysis of the Physiological Roles for lncRNAs in Development

March 8, 2014

Loyal A. Goff, Ph.D presents his research on: Genetic Analysis of the Physiological Roles for lncRNAs in Development Abstract: Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological […]

Great Deals on Insight Pharma’s Epigenetics Report

March 5, 2014

Our friends at Insight Pharma Reports created an exclusive deal, just for EpiGenie readers: Get 25% off of their new epigenetics report. This is a must have for anyone that needs to stay in tune with the epigenetics research market. There, now don’t you feel special? Epigenetics: Emerging Targets, Available Technologies, Expert Interviews, and an […]

DNA Methylation Reveals Your True Age

February 28, 2014

To the utter dismay of Hollywood actresses and men in the throes of a mid-life crises, the Epigenetic Clock has just chimed in to remind us that there really is no escaping time. A new report from Carola Weidner and team at Aachen University in Germany has just shown that, sort of like counting the rings in a […]

CRISPR-Cas, Zinc Fingers and Epigenetic Editing with Dr. Marianne Rots

February 27, 2014

Epigenetic Editing is an emerging field that has sparked interest across a number of research groups. By using a fusion of TET we can now target specific genomic regions for demethylation in order to learn about their function and regulation. We got in touch with one of the field’s experts, Dr. Marianne Rots, commissioning editor of Clinical Epigenetics, […]