epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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This Stem Cell Reprogramming is Made Possible with Generous Support from Histone H3.3

October 30, 2012

Some people dress up their pets in clothes so that they will look more like their human owners. Turns out, a similar thing happens in the nuclear transfer process to make stem cells. Jerome Jullien and colleagues in 2012 Nobel laureate John B. Gurdon’s lab (along with a number of other great researchers in France […]

GC Content and CpG Islands Keep Chromatin Open for Transcription

October 30, 2012

The word “island” conjures up images of a tropical paradise with a sandy beach and a sunny sky—a nice place to hang out. In a similar way, CpG islands turn out to be nice places for Pol II to hang out without worrying about pesky nucleosomes getting in the way, according to researchers in France […]

5-hmC Sequencing on a Budget

October 30, 2012

Whether you’re the head of a lab, household, or leading a country, budgets are a reality. Like those old jeans you can’t seem to donate, they seem to get tighter every year. So when slick, new methods surface that tackle some tough challenges like single nucleotide resolution 5-hmC profiling, researchers’ excitement is quickly tempered by […]

Three Ways to Get Intimate with Epigenetic Marks

October 24, 2012

The days of dealing with regional estimates of epigenetic marks like histone modifications and DNA methylation are just about behind us. That’s right, the maps that lie ahead will be less Thomas Guide and more GPS. Drs. Gabriel Zentner and Steve Henikoff recently took some time off from being all-star cancer researchers and pulled together […]

Natural Antisense Transcripts within Pseudogenes

October 20, 2012

EpiGenie recently reviewed the epigenetic text Non-Coding RNAs and Epigenetic Regulation of Gene Expression by Kevin Morris. To give you a little taste of the material covered in the book, here is a summary of one of the chapters: Natural Antisense Transcripts within Pseudogenes: An EST Survey by Enrique M. Muro and Miguel A. Andrade-Navarro […]

Epigenetic Regulators (miRNAs, lncRNAs) Get Regulated Epigenetically

October 20, 2012

With Halloween coming up, perhaps it is fitting that the authors of two recent papers describe a “tangled web” of epigenetic regulations. In one paper, researchers suggest that DNA methylation and perhaps other epigenetic modifications disrupt long non-coding RNA (lncRNA) activity. In the other paper, a different team shows that DNAm messes with the miRNA […]

DNA Hypermethylation of CpG Islands Doesn’t Contribute to Cancer Progression?

October 9, 2012

And in another example of turning conventional wisdom on its head, researchers from Scotland report that aberrant DNA hypermethylation of CpG island (CGI) promoters does not contribute to cancer development via silencing. Generally, those genes are already repressed before cancer even starts. Researchers have noticed for a long time that many genes’ CGI promoters are […]

Histone Variant H2A.Z Plays in Active and Repressive Elements

October 9, 2012

In this election season, few people are on the fence about their choice for U.S. president. But histone H2A.Z seemingly votes on both sides of the transcription —hanging out at active regulatory elements and at repressive ones. Researchers in Boston figured out how H2A.Z does this, and it may have to do with the different […]

DNA Methylation Spreads its Wings…Rarely

October 9, 2012

Transposable elements are a common mover and shaker in our genomes. Much like your obnoxious friend that you have to keep close tabs on at dinner parties, they’re usually kept under wraps by fancy host silencing mechanisms like DNA methylation. There’s been some evidence that suggests that the DNA methylation that silences transposable elements can […]

Hypomethylated DNA Repeats Surface in Damaged Hearts

October 9, 2012

Repetition may help the brain learn, but it can be rough on the heart. Researchers in Cambridge, U.K. have found that DNA repeats in damaged hearts are hypomethylated, and that’s associated with increased transcription. In research they published last year, the team did the first whole-genome analysis of differential DNA methylation in so-called “end-stage cardiomyopathic […]

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