epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Alzheimer Disease Gets Brain Region Specific EWAS

August 17, 2014

Epigenome-wide association studies (EWAS) appear to be the natural evolution of GWAS that has given neuroscience a epigenomic renaissance. Jonathan Mill and team from the University of Exeter Medical School and King’s College London have shown that sometimes it’s best to cover all angles and in their latest report(s) offer up some new epigenetic targets for studying the neuroscience of Alzheimer […]

Online Stem Cell Diploma from University of Ulster 2014

August 13, 2014

The University of Ulster is offering an entirely online, postgraduate diploma course in Stem Cell Biology and it’s starting soon. The course is designed to allow students to break into, or advance in a career in the stem cell field. They’ve assembled a panel of international stem cell industry experts advising on the course content […]

Non-Watson-Crick Base Pairing in the miRNA Seed Region

August 12, 2014

First epigenetics knocked Mendel off the high horse of simple inheritance and now it’s taking a shot at Watson and Crick. It seems that not even base-pairing is safe these days, with microRNA targeting demonstrating that it is anything but simple. In its latest political statement this member of the non-coding party has been caught […]

The Embryonic Journey of DNA Methylation Dynamics

August 5, 2014

Two recent Nature papers made big strides in understanding mammalian embryonic DNA methylation. The Meissner and Eggan team from Harvard focused in on CpG dynamics and how they compare to mice, specifically in terms of parental contribution. While the Qian and Tang team from Bejing examined how DNAm effects the epigenetic embryonic landscape in terms of histone […]

Gazing at Your Local Epiproteome with CRISPR-ChAP-MS

August 4, 2014

For those of you who were thinking the CRISPR/Cas9 system was just limited to genome editing, think again because the story just got a new twist. Almost like combining the bullet speed of Superman with the hi-tech gadgets of Batman, Alan Tackett and colleagues come up with a new tool to look at all the […]

Hold Your ‘breadth’ – H3K4me3 Domain Size Matters

August 1, 2014

Apple may have finally thrown the gloves off in the race for larger screens, but it appears that this is old news for cells, who have been elevating the status of important genes for years by marking them with large billboards of H3K4 tri-methylation. These genes then get the VIP treatment from cellular machinery ensuring “enhanced […]

Webinar: Using CRISPR/Cas9 Technology for Editing Genes in Haematopoietic Cells and Mice

July 29, 2014

Presented by: Dr Marco Herold, Laboratory Head, Molecular Genetics of Cancer Division, The Walter & Eliza Hall Institute of Medical Research Abstract: The CRISPR/Cas9 technology provides an easy and rapid way to edit genes in vitro and in vivo. Initial experimental strategies utilized a transient transfection approach to modulate genes in vitro, but this proved […]

Blame Your Old Man: Age-Related Sperm Methylation Changes May Up Disease Odds

July 24, 2014

Delayed parenthood in developed countries means more old dads. Who cares you ask? You should, as this trend doesn’t just increase early morning traffic at Starbucks, it can also increase the incidence of autism, bipolar disorders, schizophrenia, some forms of cancer, or other disorders that accompany the offspring of older fathers. Way to go Dad; […]

Webinar – Bringing ChIP Seq Data into Focus: Advanced Normalization Strategies

July 23, 2014

If you’ve ever struggled to make sense of your ChIP Seq data, then check out this webinar presented by our colleagues at Active Motif, to get some ideas on how to bring some order to the chaos of ChIP-seq. Presented by Brian Egan, Ph.D, Epigenetic Services Manager at Active Motif Normalization of ChIP-seq Data Today, […]

Accelerating Histone Modification Decryption

July 23, 2014

Unlike some reality show marriages that crack under the media spotlight, the union of automation and big data is still going strong, especially when it comes to cataloging histone post-translational modifications (PTM). Researchers from Princeton University show off a new systematic approach for figuring out just what all those histone PTM combinations are up to […]