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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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miRNAs Go with the Flow

September 23, 2010

Many of us dread the inevitable needle prick at the doctor’s office to draw blood, not to mention even more invasive diagnostic tests (colonoscopy, anyone?). Wouldn’t it be easier if we could just spit or pee in a cup, and from the spectrum of miRNAs in the fluid, our doctor could tell us whether or […]

DNA Methylation Holds Steady in Body Mass Index

September 17, 2010

Mules are well known for being stubborn creatures, but they aren’t alone. It seems that resistance to change is something they may have in common with body weight and certain stretches of your epigenome. Andrew Feinberg and M. Daniele Fallin at Johns Hopkins University led several teams in a study that shows, for the first […]

Grabbing Histones By The Tail

September 15, 2010

For those old-school scientists who are still using erector sets and Lincoln logs to model the interactions between histone tails and proteins, we’ve found a new interactive tool that’ll bring your histone analysis into the 21st century. A team from the Structural Genomics Consortium (a collaboration between the University of Oxford and the University of […]

In the Dark Lanes of the Library, Beware of miRNA Sequencing Bias

September 9, 2010

Advanced sequencing techniques have enabled the characterization and discovery of miRNAs to explode like an Icelandic volcano. But no matter how fancy your sequencing box is, the quality of your data still relies on the strength of your miRNA library preparation protocol. A group of curious scientists from the Beijing Genomics Institute and the Chinese […]

Polymerase Furiosus Over Lack of Credit in Bisulfite Sequencing

September 1, 2010

At EpiGenie, we try to call attention not just to the big names in the field that nab most of the limelight, but also to the folks busting their pipettes day and night for new discoveries. So why not give a shout out to a workhorse in the most widely used method for methylation analysis, […]

Silencing of Ultraconserved ncRNAs Is Not So Golden in Cancer

August 31, 2010

If you live near a construction site, are listening to one half of a cell-phone conversation in a movie theater, or stuck on an airliner next to a fussy infant, then for you silence may indeed be golden. But, for certain ultraconserved non-coding RNAs, transcriptional silencing can lead to a cellular uproar. A new article […]

DNA Methylation States Mix and Mingle on the Nuclear Dance Floor

August 31, 2010

Remember those lame junior high dances, where most of us stood silently and uncomfortably against the gym wall, watching our wilder classmates rock out to Bon Jovi on the dance floor? Some researchers think that methylated and unmethylated promoters in tumors segregate themselves in the same way: silenced genes gather in heterochromatin at the nuclear […]

The Epigenetics of Mental Illness

August 31, 2010

Mental disorders like depression will likely affect 1/6 of Americans at some point in their life. That probability might be higher if you’re a Cleveland sports fan, but seriously, with mental illnesses affecting hundreds of millions of people globally each year, we’re glad to see an increasing focus on the epigenetics of these disorders. In […]

Mecp2, miR-212 Keep Cocaine Addiction In Check

August 18, 2010

Anyone who’s ever seen an episode of Celebrity Rehab knows that addiction is a very complicated issue, and as scientists recently found out, even the molecular basis of addiction is no simple matter. A group led by Paul Kenny at Scripps Florida studied cocaine use in rats that were allowed to dose themselves with the […]

5-Hydroxymethylcytosine Gets Sensitive

August 17, 2010

One of the great things about science is that whenever a new problem presents itself, there are always some members of the community who set out to find innovative solutions. In this case, it’s been a bear to detect and quantify 5-hydroxymethylcytosine (5-hmC) but some cagey researchers at the Ludwig Maximilians University (LMU) in Munich, […]

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