epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Reactivating “Fossil” Enhancers from Embryonic Development in Adult Tissues

April 10, 2019

The Jurassic Park movies got the whole world excited about resurrecting dinosaurs from fossilized DNA, but more recent findings that the half-life of DNA is only 521 years mean that dream is science fiction. So, while the finer details of dinosaur genomes may be lost in the fossil record, new work has dug up epigenomic […]

Histone Demethylases Have a “Sixth Sense” about Oxygen Levels!

April 7, 2019

Many people make dubious claims of being endowed with more than the five traditionally recognized senses; their “sixth sense” providing the extrasensory perception needed to converse with spirits and ghosts and predict the future, among other fanciful claims. While there is a lack of any evidence for extrasensory powers and paranormal activity, robust studies have […]

Inflammation in the Information Age: Multi-Tissue Chromatin and Transcriptional States of Mammalian Aging

March 26, 2019

We’re living in the information age―the age of supercomputers, big data, and machine learning―and the epigenetics field is capitalizing on these capabilities. New research from the lab of Anne Brunet at Stanford University harnesses the power of the ‘information age’ to provide insight on the ‘inflammation age’―that is, changes in the epigenetic landscape that lead […]

Histone Methylation Has a New Sidekick and Its Name is Serotonin!

March 17, 2019

Watch out epigenomic evil-doers, histone H3 has a new sidekick to help it keep gene regulation in shape. By day, serotonin can be found in its traditional role as a neurotransmitter; being released by cells of the nervous system and binding to specific receptors to impact a wide range of functions, from cognition to gut motility. […]

New Sequencing Technique TAPS into Genome-Wide DNA Methylation Profiles Without the BS

March 12, 2019

While trying to uncover the mysteries of the DNA methylation, a lot of BS is often required. And no, we’re not talking about workplace politics but rather sodium bisulfite (BS) conversion. Thankfully, the labs of Chun-Xiao Song and Benjamin Schuster-Böckler at Oxford University (UK) have developed a new “BS-free” approach to uncover the secrets of the […]

Don’t Turn the Other Cheek on Heterogeneity in Buccal Cell Samples

March 12, 2019

When it comes to brushing, whether it’s your teeth or a cheek swab sample, proper technique is important. Your dentist may have already told you not to brush you teeth too hard, but it turns out how you collect a cheek swab is also important. Buccal epithelial cells are perhaps the most clinically accessible tissue […]

EZH2 Gets a TAD Involved in Cancer

February 26, 2019

In the Venn diagram of epigenetics and cancer biology, EZH2 sits perfectly in the overlap. This methyltransferase is responsible for tri-methylation of lysine 27 on histone 3 (H3K27me3) but is also an oncogene, mutated in a variety ofhumancancers. H3K27me3 is a marker of inactive chromatin domains, specifically topologically associating domains (TADs), and has been linked to […]

Epigenetic Editing with CRISPR Keeps Crops Crisp in Today’s Climate

February 25, 2019

While the crisper drawer of our fridge is the best way to keep our produce fresh, epigenetic editing research now brings forth CRISPR-based manipulation of DNA methylation to keep our crops crisp. This tasty treat comes at you in the form of two new publications from the lab of Steven Jacobsen (UCLA), where the talented team expand […]

When Two Is Not Better Than One: Duplicitous Dipeptides Disrupt Heterochromatin to Promote Neurodegeneration

February 25, 2019

While some protein aficionados may believe that the only thing better than one peptide is a dipeptide, a study from the lab of Leonard Petrucelli (Mayo Clinic, USA) recently established that the expansion of double-dealing dipeptide repeats promotes the development of neurodegenerative disease via the disruption of heterochromatin structure and function. The diseases in question, […]

Orange You Glad for Methylation’s Role in Fruit Ripening?

February 12, 2019

If you like to start your day with a glass of orange juice, you can thank epigenetics for that. More specifically, you can thank DNA methylation, since it’s been recently shown to play a crucial role in the ripening process of the sweet orange fruit. The collaborative efforts of Jian-Kang Zhu at Purdue University (Indiana, […]

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