epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Your Brain on Stress: The Role of Dynamic DNA 6mA Modification

October 30, 2017

Stress has a way of getting under our skin, where it can sink in so deep that it modifies our brain’s DNA. While it can alter DNA cytosine modifications, such as 5-methylcytosine (5mC), a new role for the N6-methyladenine (6mA) modification in stress response has now emerged. DNA 6mA has recently made the grade as […]

UBE3A Networks with Other Imprinted Genes to Shape Neurodevelopment and Autism

October 24, 2017

Networking shapes our brains in many ways; whether it be in a professional, social, or genomically imprinted fashion. Linking us into the latter, new findings from the lab of Janine LaSalle at the University of California, Davis, uncover a hub in an imprinted gene network critical to neurodevelopment. The imprinted 15q11-q13 locus is involved in […]

The Hi’s and Lo’s of Cohesin’s Crafty Chromatin Concerto

October 18, 2017

While solos are the key to some of your favorite tunes, a masterpiece as magnificent as chromatin conformation is hardly the work of a one-man band; instead, it takes an orchestra of histone modifications to complement and counterpoint cohesin´s sonorific solos. Now, a duet from the labs of Francois Spitz (Pasteur Institute, France) and Leonid […]

dCas9-SunTag-DNMT3A Causes a Total Methylation Eclipse

September 26, 2017

While it’s never a great idea to stare directly into the sun, a DNA methyltransferase (DNMT) eclipse brought to you by the SunTag system may just steal your eyes during its totality. This designer epigenome editing system comes to you from the labs of Margaret A. Goodell and Wei Li at Baylor College of Medicine […]

xQTLs Provide Xtra Epigenetic Treasure for GWAS Prospectors

September 25, 2017

On any good pirate map, ‘X’ marks the spot for buried treasure. It turns out the same is true in epigenetics: xQTL analysis marks the spot for buried GWAS associations. Genome-wide association studies (GWAS) have been instrumental in identifying single nucleotide polymorphisms (SNPs) associated with human disease. However, finding the biological relevance of such SNPs […]

Caloric Restriction: The Fountain of (Epigenetic) Youth?

September 25, 2017

With age comes wisdom, and also a changing methylation landscape. These changes in methylation can predict life expectancy, with a subset referred to as the ‘epigenetic clock’. For those of us looking to add more time, caloric restriction has been shown to increase life expectancy and reduce the incidence of age-related diseases. Despite three decades […]

Phthalates Produce Problematic Sperm DNA Methylation in Humans

September 20, 2017

While plastic is fantastic, the luxury of our synthetic world comes at a price: plasticizing agents can affect our chances of bringing new life into that world thanks to our environmentally-responsive sperm. Phthalates, which are common plasticizing agents, disrupt the endocrine system and are present in food packaging, personal care products such as shaving cream, […]

DNA Methylation Takes a World Tour of Human Diversity

September 20, 2017

Once a rock star makes it big, they treat the world to a tour. However, DNA methylation, being both an epigenetic rock star and an unbearable diva, has been more than fashionably late to the party! But fear not! DNA methylation has made a comeback with a hit record of scientific insight into human diversity. […]

LINE-1 Retrotransposons Keep Early Embryonic Chromatin in Line

September 10, 2017

While cocktails and embryonic development usually don’t mix well, a cocktail of three transcription-activator-like effectors (TALEs) has just shaken up our understanding of the role LINE-1 retrotransposons during early embryonic development. LINE-1 activation had been considered a consequence of developmental processes, but now a talented team from the lab of Maria-Elena Torres-Padilla at the German […]

Targeted and Reversible Chromatin Conformations Crafted by CLOuD9

August 27, 2017

Imagine a world where you could create chromatin loops where and when you want. You’d feel like you’re on cloud nine. Well, get your head out of the clouds, because you’ve got to thank the lab of Kevin Wang at Stanford for targeted and reversible chromatin loop reorganization using deactivated Cas9 (CLOuD9). The CLOuD9 system […]

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