epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Maladaptive Memories are Mediated by Methylated Histones and ΔFosB in the Mouse Hippocampus

September 10, 2019

The air is starting to get crisp, the first few leaves are changing color and you can suddenly buy pumpkin-spice everything – these contextual cues can only mean one thing; you’d better start studying for your midterms! But wait, you haven’t had to worry about exams for years… Thanks to your hippocampus and epigenetics, environmental […]

This Is the Methylome that Alzheimer’s Built

September 9, 2019

“This is the House that Jack Built” is a popular and beloved children’s rhyme. But if children’s rhymes were written by scientists instead, it might look something like this: There’s an oxidation reaction on a methyl group, on a carbon in a cytosine, in a region of a gene, in the genome of a neuron, […]

Methylation Prevents Young Transposable Elements From LINE-1 Dancing Through the Neural Genome

August 13, 2019

Whether you’re a fan of nightclubs, speakeasys, or honkey-tonks, you may have noticed that the population on the dance floor seems to get younger every year. Maybe you’re just getting older, or maybe today’s youth are getting better at getting around the rules. Like bouncers at a bar, developing cells have DNA methylation to keep […]

LADL-ing Up a New Optoepigenetic Chromatin Looping Technique

August 12, 2019

For your daily serving of epigenetics brain food, look no further than the entwined spaghetti-like chromatin. Although it may look like a bowl full of chaos, there are distinct domains and long-range genomic interactions that function in a variety of regulatory roles. A team at the University of Pennsylvania (USA) led by Jennifer Phillips-Cremins and […]

ChIP 101: Beginner’s Guide to ChIP Assays

July 24, 2019

Become a ChIP Assay Expert! The chromatin immunoprecipitation (ChIP) assay is one of the best ways to study the association of DNA-binding proteins with chromatin and the localization of histone modifications throughout the genome. But ChIP assays take time to master. Our friends at Active Motif have put together this free ChIP 101 eBook that […]

SMARCA2 Variants Leave a Domain-Specific DNA Methylation Signature in Neurodevelopmental Disorders

July 16, 2019

Our signatures are unique marks that let people know where we’ve been. It turns out that epigenetic modifiers leave their own signatures on the genome. There are between 300-400 proteins that regulate the epigenome, including readers, writers, & erasers of histone marks as well as chromatin remodelers. Genetic variants in the epigenes that encode these […]

Evasive Maneuvers! LINE-1 at the Helm Outwits Epigenetic Repression

July 16, 2019

While the above title may conjure up images of Star Wars-esque galactic battles, the epic clash between the LINE-1 (L1) retrotransposon and repressive forces takes place on the scale of microns instead. This war has been waging in the human genome for thousands of years: L1 attempts to replicate and integrate into the genome, while […]

Shifting Sex: Social Stress Throws Epigenetics in Reverse for Female Bluehead Wrasses

July 15, 2019

Have you ever run into an unexpected detour on your commute? Whether it be an ice patch, flood, or even a mudslide, mother nature can reroute even the best laid plans, but for some species, changes in the environment have much higher stakes than being late for work or that much needed vacation. In fact, […]

Mitochondrial Memes: How the Powerhouse of the Cell also Drives Epigenomic Alterations

July 12, 2019

The appreciation of the mitochondrion as “the powerhouse of the cell” has become as culturally pervasive as some of our favorite memes; however, a powerful new study now shows that signals deriving from this double-membrane-bound ATP-generating organelle represent a major driving force behind alterations to the epigenome. A talented team of researchers from the lab […]

Epigenetic Heirlooms: The C. elegans Behavioral Legacy is Inherited Through Small RNAs

July 2, 2019

Some families have heirlooms that get passed down from generation to generation but if you’re a nematode, you might inherit more than just your Grandpa’s pocket watch! The phenomenon of transgenerational epigenetic inheritance (TEI) was first discovered in Caenorhabditis elegans, where environmental stressors can alter physiological responses in offspring up to 20 generations later! Since […]

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Epigenetics and ncRNA Headlines

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