epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Gut Microorganisms Make Epithelial HDAC3 Work to their Rhythm

October 7, 2019

While many of us prefer the sound of silence, others feel the need to inject a little rhythm into their everyday lives; but how do you do it? Spinning a few records at home, moving to the beat at Samba lessons, or do you use the microorganism-mediated activity of Hdac3 in your gut?! While researchers […]

Webinar: The Epigenetics of the Exposome and Aging – Paul G. Shiels

October 2, 2019

Don’t miss this great webinar detailing some of the latest discoveries about the role of epigenetics in aging. Aging results in a gradual and progressive loss of physiological functions and physical abilities over time. Overcoming the growing burden of age-related issues is one of the greatest challenges facing modern society. These issues are leading to […]

Sherlock Genomes: Stimulation Leaves Epigenetic Evidence Behind in Neurons

September 30, 2019

Even the most careful criminals leave some kind of evidence; a fingerprint or a strand of hair can be enough for a clever investigator to link them to the scene of the crime. Although it’s far from an open and shut case, new research in mice shows that the epigenome of neurons contains chromatin clues […]

The Tn5 Transposase Takes Single-cell ChIP-Seq to the Next Level

September 18, 2019

It’s never good to see someone lagging behind the rest, but while stepwise developments to single-cell chromatin immunoprecipitation and subsequent parallel sequencing techniques (ChIP-seq) have led to gradually improved yields and increased sensitivity with reduced numbers of cells since the first report of a single-cell ChIP protocol, we still lack widely-applicable and low-cost methods to […]

Maladaptive Memories are Mediated by Methylated Histones and ΔFosB in the Mouse Hippocampus

September 10, 2019

The air is starting to get crisp, the first few leaves are changing color and you can suddenly buy pumpkin-spice everything – these contextual cues can only mean one thing; you’d better start studying for your midterms! But wait, you haven’t had to worry about exams for years… Thanks to your hippocampus and epigenetics, environmental […]

This Is the Methylome that Alzheimer’s Built

September 9, 2019

“This is the House that Jack Built” is a popular and beloved children’s rhyme. But if children’s rhymes were written by scientists instead, it might look something like this: There’s an oxidation reaction on a methyl group, on a carbon in a cytosine, in a region of a gene, in the genome of a neuron, […]

Methylation Prevents Young Transposable Elements From LINE-1 Dancing Through the Neural Genome

August 13, 2019

Whether you’re a fan of nightclubs, speakeasys, or honkey-tonks, you may have noticed that the population on the dance floor seems to get younger every year. Maybe you’re just getting older, or maybe today’s youth are getting better at getting around the rules. Like bouncers at a bar, developing cells have DNA methylation to keep […]

LADL-ing Up a New Optoepigenetic Chromatin Looping Technique

August 12, 2019

For your daily serving of epigenetics brain food, look no further than the entwined spaghetti-like chromatin. Although it may look like a bowl full of chaos, there are distinct domains and long-range genomic interactions that function in a variety of regulatory roles. A team at the University of Pennsylvania (USA) led by Jennifer Phillips-Cremins and […]

ChIP 101: Beginner’s Guide to ChIP Assays

July 24, 2019

Become a ChIP Assay Expert! The chromatin immunoprecipitation (ChIP) assay is one of the best ways to study the association of DNA-binding proteins with chromatin and the localization of histone modifications throughout the genome. But ChIP assays take time to master. Our friends at Active Motif have put together this free ChIP 101 eBook that […]

SMARCA2 Variants Leave a Domain-Specific DNA Methylation Signature in Neurodevelopmental Disorders

July 16, 2019

Our signatures are unique marks that let people know where we’ve been. It turns out that epigenetic modifiers leave their own signatures on the genome. There are between 300-400 proteins that regulate the epigenome, including readers, writers, & erasers of histone marks as well as chromatin remodelers. Genetic variants in the epigenes that encode these […]

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