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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Epigenetic Silencing of the Y-chromosome Controls the Extent of Male Toxicity

December 7, 2020

While “toxic masculinity” may seem intimately linked to the human species, the fruit fly Drosophila has come to show us that their Y-chromosome acts as a source of genomic male “toxicity” that epigenetic silencing keeps in check. Specifically, we know that the formation of silent heterochromatin domains during development represses the activity of transposable elements […]

The Powerhouse Of The Cell Is At It Again! Mighty Mitochondria Modify DNA Methylation and Mortality

November 24, 2020

If there’s one thing we can all agree on, it’s that mitochondria are the powerhouse of the cell. Adding to this prowess is a new finding showing that the amount of mitochondrial DNA impacts nuclear DNA methylation and gene expression, ultimately influencing mortality and cardiovascular disease. While we’ve seen how mutant mitochondria can influence histone […]

How I Met Your Mother: DNMT3A from Mom Leaves its Mark on Dad’s Genome in the Early Embryo

November 24, 2020

While stories of Mom meeting Dad often leave their mark on a family, and sometimes a nation, the plot has now thickened thanks to new findings showing that Mom’s DNMT3A leaves its mark on Dad’s genome in the early embryo. DNA methylation in the male germline undergoes massive changes during preimplantation. High paternal DNA methylation […]

Turning the Spotlight on Extraordinary Epigenetics Content

November 13, 2020

Our sponsors help keep the lights on, the Wi-Fi humming, and our epigenetic content flowing to your screens each week. And while we may be a tad biased, we want to turn the spotlight on the range of highly useful and always educational epigenetics content from these websites that you should check out! Dovetail Genomics […]

Special Multiomics Feature: Combinatorial DNA Methylation and Chromatin Assays Serve Up New Insight

November 9, 2020

Combinations of old favorites can be even tastier than the sum of their parts. Who doesn’t leave peanut butter and jam, chips and dip, and DNA methylation and chromatin assays? While they sound appetizing, those last two aren’t quite as easy to get together. Many assays have been developed in the past to combine ChIP […]

Long-Sperm Effects: THC and Nicotine Have A Lasting Impact on Bivalent Chromatin and Autism Genes

November 4, 2020

While some fathers planning a family may be left in a bivalent state when deciding about smoking cannabis or nicotine, new research has cleared the air. THC and nicotine both prime an autism spectrum disorder profile in sperm through altering DNA methylation within bivalent chromatin states. In their seminal paper, researchers from the lab of […]

Low-Pass WGBS of Newborn Dried Blood Spots: A Methylome-Wide Role for the RUNX1 Super-Enhancer in Down Syndrome

October 23, 2020

While collecting blood spots may seem like a hobby best left for a TV serial killer like Dexter Morgan, a novel low-pass whole-genome bisulfite sequencing (WGBS) approach has shown that newborn dried blood spots are more than just a trophy. Their entire methylome can be assayed to answer enticing epigenomic enigmas. DNA methylation array studies have […]

X Marks the Spot for Neurodevelopment in the Autism Spectrum Disorder Cord Blood Methylome

October 19, 2020

Every good pirate knows that X marks the spot on their treasure map, but what’s one to do when it’s surrounded by the dangers of uncharted territory? Thankfully, when it comes to the unexplored regions of the Autism Spectrum Disorder (ASD) DNA methylome, whole genome bisulfite sequencing (WGBS) has illuminated the way to the X chromosome […]

Multi-omic Analyses Highlight an Epigenetic Treatment Strategy for Early-stage Alzheimer’s

October 19, 2020

Given the unfortunate failure of many treatment strategies for late-stage Alzheimer’s disease, researchers recently sought to gain some fresh new perspective from multiple angles by mounting a three-pronged transcriptomic, proteomic, and epigenomic attack to decipher the mechanisms controlling disease progression. Excitingly, the team behind this study now highlight the possibility of an early-stage epigenetic therapy […]

Racing Against the Epigenetic Clock: PRDM8 and Premature Aging

October 5, 2020

Scientists are always working against the clock, and recently, a team led by Wolfgang Wagner (RWTH Aachen University, Germany) used their ever-evaporating time to explore a potential link between telomere shortening and epigenetic clock acceleration in premature-aging associated bone marrow failure syndromes and describe a new disease biomarker! Patients with premature aging and difficult-to-diagnose bone […]

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Epigenetics and ncRNA Headlines

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