epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Summitting With PeakSeq.It’s About Mappability

January 10, 2009

ChIP-seq continues to assault bioinformatics teams with avalanches of data, but the upside of using this powerful approach brings some challenges along with it. Modeling background accurately requires a few tweaks, so before you get all excited about the double black diamond peaks that you’re seeing in regulatory motifs, you might want to factor in […]

Bisulfite Sequencing the “Other” Nucleic Acid: Methylated RNA

December 16, 2008

What’s good for the goose is good for the gander, so why shouldn’t bisulfite sequencing be used to study RNA cytosine methylation? Until recently, the harsh reaction conditions required for bisulfite deamination were considered detrimental to RNA stability. However, Matthias Schaefer and colleagues developed an RNA bisulfite sequencing procedure that reproducibly and quantitatively detected cytosine […]

To Code or Not to Code…Is that the Question?

December 10, 2008

In the past few years, ncRNAs have progressed from interesting anomalies to what some researchers think constitute the majority of the mammalian transcriptome. However, as reviewed by John Mattick and coworkers at the University of Queensland and the Ludwig Institute for Cancer Research (both in Australia), it’s increasingly difficult to distinguish coding from noncoding RNAs […]

Let It Sno

December 2, 2008

It’s December, the time of year when much of the States is blanketed in a frosty mantle of the white stuff. But as recently reported in Molecular Cell, the ACA45 RNA appears to have pulled the ultimate snow job. Nikolaus Rajewsky, Gunter Meister, and colleagues revealed that ACA45, which was previously thought to function exclusively […]

miRNA Fights Cancer-Promoting Histone Methyltransferase

November 23, 2008

What makes some tumors as gentle as purring kittens and others of the same cancer type as ferocious as saber-toothed tigers? A miRNA (miR-101) was recently shown to take a bite out of cancer by inhibiting the EZH2 histone methyltransferase. The study by Arul Chinnaiyan and co-workers at the University of Michigan Medical School, the […]

ncRNAs on the Brain

November 17, 2008

Do you remember the name of your fourth-grade teacher? How about what you had for lunch last Thursday? Highschool Prom date? Yeah, we went stag too, but if you’re having a hard time remebering key events, ncRNAs may be to blame! The human brain expresses high numbers of ncRNAs, and mounting evidence indicates important contributions […]

Chromatin Context Tip(60)s the Transcriptional Balance in ESCs

November 12, 2008

Unfortunately, the KISS principle (‘keep it simple, stupid’) doesn’t apply to chromatin. Although we’d like to think that certain histone modifications are always “good” for gene transcription and others are invariably “bad,” Barbara Panning and co-workers at the University of California San Francisco have found that in embryonic stem cells (ESCs), the transcriptional outcome of […]

Silencing Is in the Air

November 12, 2008

Everywhere you look, be it Science or Nature, US Weekly (OK, not quite), silencing by ncRNAs is making headlines. But the targets and mechanisms of this silencing are not always clear. A recent report by Peter Fraser and co-workers at The Babraham Institute (UK) and several other universities and centers in Japan and Europe has […]

Epigenetic Changes in a Hard-to-Treat Childhood Cancer

November 5, 2008

A very difficult-to-treat childhood leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on. Children with the subtype of acute lymphoblastic leukemia (ALL) known as MLL-AF4 have a cure rate of just under 50 […]

New Method HITS RNA-Protein Interaction Sites

November 5, 2008

DNA, it has turned out, isn’t all it was wound up to be. In recent years we learned that the molecule of life, the discovery of the 20th century, did not-could not-by itself explain the huge differences in complexity between a human and a worm. Forced to look elsewhere, scientists turned to RNA; however, methodological […]

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