epigenetics

Epigenetics and ncRNA Headlines

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DNA Methylation Keeps iPS Cells Living in the Past

April 19, 2011

Some people are convinced that they’ve lived a past life, recalling snippets of someone else’s memories from a different time and place. Now, without the benefit of hypnosis, researchers have discovered that induced pluripotent stem (iPS) cells also retain transcriptional memories of past lives as somatic cells, which can be at least partially explained by […]

DNA Methylation May be Secret to Dieting Success

April 13, 2011

The theory behind most diets seems simple enough: Eat less calories; Lose more weight. But we all know that’s way easier said than done, and now there’s some epigenetic reasons why. A new study found that promoter methylation of key obesity linked genes can predict the success of low-calorie diets. Researchers from the University of […]

miRNAs Better at Predicting Outcome Than NCAA Seeds

April 12, 2011

After this year’s March Madness Tournament, many people are wondering whether predictive measures have any relation to outcome in the real world. Luckily, scientists are too busy to watch that many basketball games. Since the best defense is a good offense, researchers from Luxembourg and Seattle teamed up to try to identify markers that could […]

Formaldehyde Fumes Foil miRNA Expression

April 12, 2011

Anyone who’s gotten too close while pouring an RNA gel knows the eye-burning, nose-hair-singeing bite of formaldehyde fumes. Even outside the lab, we breathe in trace levels of formaldehyde released from car exhaust and manufacturing processes. Now researchers at the University of North Carolina-Chapel Hill have uncovered changes in miRNA expression of lung cells exposed […]

Nickel Exposure Takes Its Toll Via H3K4me3

April 11, 2011

It’s been known for a while that nickel-based compounds are linked to cancer. In fact, if we had a Nickel for every time we hear about how dangerous nickel exposure is, well, we might be able to buy a cup of coffee (Nickels just aren’t worth what they used to be!). But the point is, […]

Embryonic Stem Cells and their 5hmC Highwire Balancing Act

April 5, 2011

With new tools and techniques to study the sixth base, 5-hydroxymethylcytosine (5-hmC), reports starting to pour in to shed new light on just what the heck it does. Now researchers in the UK have shown that changes in the relative levels of 5mC and 5hmC in embryonic stem (ES) cells could help tip cells toward […]

DNA Methylation qPCR Remixed

April 5, 2011

qPCR is used daily to validate array and sequencing results, but qPCR approaches have yet to dominate DNA methylation analysis the same way they have with other applications like gene expression analysis or genotyping. Things are a little bit more complicated when it comes to the epigenetic mods, but that hasn’t stopped hungry researchers from […]

Chromatin States Get On the Map

March 30, 2011

Deciphering chromatin status across an entire genome must seem like trying to navigate through an Amazon rain forest without a guide. Luckily, new work just published begins the process of creating chromatin state roadmaps to help point epigenetics researchers down the right path. To make that journey a little smoother, a research group from MIT […]

miRNA Mimics Take Imperfect Aim at Gene Promoters

March 29, 2011

Sometimes a perfect match isn’t all it’s cracked up to be – just look at the Hollywood divorce rate. Whether you’re talking relationships or ncRNAs, a few mismatches between partners can still lead to a successful outcome. That seems to be the case for small RNAs that recognize gene promoter regions, as revealed by researchers […]

Making The ChIP Antibody Grades

March 29, 2011

Back in the 2000’s most researchers spent their post-ChIP analysis looking at a gel or a PCR curve. Now, they spend their analysis time combing through hard drives of sequencing data. A lot has changed in the world of location analysis, but the need for good antibodies remains the same; which is probably why we […]

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