epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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ATAC-see Assaults Chromatin from Two Fronts: Visualization and Sequencing

November 24, 2016

After playing hide-and-seq with chromatin for a while, we’re sure you’ve been begging for a new plan of attack to help you see what’s going on. Thankfully, a Northern California collaboration led by the lab of Howard Chang alongside the labs of William Greenleaf, Jan Liphardt, and Jennifer Doudna has brought forth a tactic to […]

Dnmt3C: A New Piece of DNA Methylation Machinery

November 24, 2016

A dog walk in the countryside led to Velcro, the search for chest pain therapies gave us (who me?) Viagra, and a messy microbiology lab bench provided penicillin. Some big research discoveries appear to have arrived in an “accidental” form and maybe, just maybe, new research from the laboratory of Déborah Bourc’his can be spoken […]

SALL4A Sets the Mood for a DNA Demethylation TET-á-TET

November 16, 2016

A romantic “tête-à-tête” between two lovebirds usually involves helping factors which set the mood and make the night move along slickly. A good wine, some soft lighting, and maybe even a little smooth jazz! While that might work for the humble researcher, the “TET-á-TET” involved in DNA demethylation is a slightly different affair and demands […]

The Delicate Balance Between H3K27me2 and H3K27me3 Decides Stem Cell Fate

November 15, 2016

The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27me) via its catalytic subunit Ezh2. While H3K27me3 and H3K27me1 have been associated with gene repression and activation respectively, the exact role of H3K27me2 remains under-explored. However, recent works in temperature-sensitive drosophila and in PRC2 knock out embryonic stem cells (ESCs) suggest a role […]

Hi-C Captures Chromosome Contacts Critical to Cognition, CRISPR/Cas9 Confirms

November 15, 2016

In today’s world there’s not much you can be sure of, particularly when it comes to understanding the complexities of human cognition. Thankfully, the epigenome offers some much needed explanation, as demonstrated by the insight gained from DNA methylation maps of human neurodevelopment. However, genetic interactions created by 3-D chromosome structure have remained more of […]

Intergenerational Transmission of Extracellular dsRNA Filmed in C. elegans

November 1, 2016

Seeing is believing, whether it be a topic as hot as the upcoming presidential election or intergenerational epigenetic effects and transgenerational epigenetic inheritance. While exciting evidence on the role of sperm RNA in mammals has begun to accumulate thanks to the labs of Mansuy, Bale, and Rando, an elegant C. elegans study from the lab […]

ChIP-SICAP – Your New Favorite Assay Flavor?

November 1, 2016

Maple-bacon, chocolate, and hedgehog? The list of potato chip flavors keeps on getting longer and crazier. Also getting longer is the list of different ChIP assay varieties (that’s chromatin immunoprecipitation for the uninitiated), with the most interesting new “taste sensation” emanating from the lab of Jeroen Krijgsveld (DFKZ/EMBL, Heidelberg, Germany). While chips are good for […]

Variation in CpG Methylation is Tied to Biological Aging

October 19, 2016

There aren’t many things in this world that we can be certain about, but aging marks an all too important exception. Towards the goal of understanding the marks of this unavoidable process, we’ve seen the epigenetic clock, which looks at CpG sites that are certainly differentially methylated as we age. However, a new perspective to […]

Meta-Analysis Reveals Grim Reaper is Keeping an Eye On Your Epigenetic Clock

October 19, 2016

They say ‘Seasons don’t fear the reaper’, and while the festivities of this season certainly favor the reaper, most of us dread the reaper’s favor. Our understanding of how to avoid that favor is now improving, thanks to some new insight from the epigenetic clock-watching lab of Steve Horvath at UCLA. The epigenetic clock consists […]

Cancer Stem Cells Refuse to be Linked to Linker Histone H1.0

October 19, 2016

It is widely known that tumor lesions harbor diverse subpopulations of cell types each genetically and phenotypically unique. However, it is not always clear which cell types are actually promoting or sustaining the tumor. Typically, tumors consist of two class of cells—a subpopulation of cells that are fully differentiated and possess little to none tumor […]

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