epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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DNA Methylation Provides New Insight into the Missing Heritability of ALS

March 31, 2022

The devastating and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) has an estimated heritability rate of around 50%, suggesting that a considerable portion of disease risk derives from environmental and lifestyle risk factors that can leave their mark on the epigenome. Can DNA methylation analysis provide new insight into the missing heritability of ALS? In […]

Welcome to the Jungle! N4-acetyldeoxycytosine is a Wild New DNA Modification Identified in Plants and Detected in Humans

March 14, 2022

It’s time to welcome a new DNA modification to the epigenetic jungle! A collection of more than seventeen modifications have been spotted in the wilds of genomic DNA; however, only the biological effects of the prevalent 5-methyldeoxycytosine (5mC) (and its oxidated family members), along with N6-methyldeoxyadenosine (6mA) have been explored in any depth. Do other […]

CUT&Tag Launches to the Final Frontier: Spatial Epigenomic Profiling of Histone Modifications

March 14, 2022

Space: the final frontier – CUT&Tag has just voyaged where no next-generation sequencing method has gone before to bring forth spatially-resolved histone modification profiles of intact mouse tissues! An expeditionary force led by Rong Fan (Yale University) combined in situ cleavage under targets and tagmentation (CUT&Tag) chemistry, microfluidic deterministic barcoding, and next-generation sequencing to develop […]

“Is this the real-life? Is this just fantasy?” – CultureAGE Shows How In Vitro Studies Reflect In Vivo Epigenetic Aging

February 21, 2022

Profiling epigenetic aging with in vitro cell models may allow for a deeper understanding of the difficult-to-decipher in vivo process, but only if one truly reflects the other; this leaves us wondering: “Is this the real-life? Is this just fantasy?” In their epigenetic rock opera, bohemians from the lab of Morgan Levine (Yale School of […]

Can Disrupting Chromatin Interactions Stop SARS-CoV-2 in its Tracks?

February 21, 2022

Viral infections can appear like a runaway train, careering through the human body without a brake in sight; however, the meandering journey taken for the development of antivirals has now discovered a new way to stop runaway SARS-CoV-2 infections in their tracks thanks to CRISPR technology and a trip through the chromatin landscape of infected […]

Epigenetic “Baby-steps” Repress Germline Genome-defense During Development

February 4, 2022

Much like a set of helping hands can guide, support, and protect a toddler taking their first steps, the guiding force of epigenetics during embryonic development ensures genome stability and supports healthy development by regulating the expression of key genes. Such genes include DNA methylation-sensitive “germline genome-defense” genes, which undergo DNA demethylation and become expressed […]

Want to Navigate the Epigenomics of Disease Across 3,604 Studies? There’s An App For That

February 1, 2022

Traveling through large cities is complicated. Thankfully, our apps help us find a way through the maze and lead us to our destination. Now, a new method has come forward to do the same for the epigenomics of disease. A group led by Charles Breeze and Sonja Berndt (National Cancer Institute) have developed a program that guides […]

Down the Wrong Path: Trisomy 21 Pushes Neural Progenitors Towards Senescence Profile

January 31, 2022

Although it sometimes feels like there is no right way to age, intriguing insight from Down Syndrome has given insight into how disrupted nuclear architecture can push us down the wrong path. Down syndrome results from the triplication of chromosome 21 and is a leading cause of intellectual disability. However, Down syndrome is also a […]

Like a RedChIP to a Bull! – New Technique Explores RNA-Protein-DNA Interactions

January 30, 2022

The publication of a new technique is like waving a red rag to a bull for many in the epigenetics arena. Now, “RedChIP” has us stampeding in anticipation towards the exploration of the complex interactions taking place between RNA, DNA, and proteins in the nucleus. Olé! Non-coding RNAs (ncRNAs) interact with proteins and DNA to […]

Architectural Woes Prompt Age-related Problems Thanks to Genes Lacking CpG Islands

January 20, 2022

As cracks to walls and beams can lead to an old house coming apart at the seams, the architectural alterations associated within an aging nucleus can prompt degenerative processes at the cell and tissue level. While any good architect can identify and help to sure up the problematic elements bringing down the house, the blueprints […]