epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Want to Navigate the Epigenomics of Disease Across 3,604 Studies? There’s An App For That

February 1, 2022

Traveling through large cities is complicated. Thankfully, our apps help us find a way through the maze and lead us to our destination. Now, a new method has come forward to do the same for the epigenomics of disease. A group led by Charles Breeze and Sonja Berndt (National Cancer Institute) have developed a program that guides […]

Down the Wrong Path: Trisomy 21 Pushes Neural Progenitors Towards Senescence Profile

January 31, 2022

Although it sometimes feels like there is no right way to age, intriguing insight from Down Syndrome has given insight into how disrupted nuclear architecture can push us down the wrong path. Down syndrome results from the triplication of chromosome 21 and is a leading cause of intellectual disability. However, Down syndrome is also a […]

Like a RedChIP to a Bull! – New Technique Explores RNA-Protein-DNA Interactions

January 30, 2022

The publication of a new technique is like waving a red rag to a bull for many in the epigenetics arena. Now, “RedChIP” has us stampeding in anticipation towards the exploration of the complex interactions taking place between RNA, DNA, and proteins in the nucleus. Olé! Non-coding RNAs (ncRNAs) interact with proteins and DNA to […]

Architectural Woes Prompt Age-related Problems Thanks to Genes Lacking CpG Islands

January 20, 2022

As cracks to walls and beams can lead to an old house coming apart at the seams, the architectural alterations associated within an aging nucleus can prompt degenerative processes at the cell and tissue level. While any good architect can identify and help to sure up the problematic elements bringing down the house, the blueprints […]

A Suite of New Tools to Solve Single-cell Epigenetic Enigmas

December 23, 2021

Welcome explorers of the epigenome! Are you looking for new tools to help answer the toughest of epigenetic enigmas? Then check out this suite of single-cell methods papers from technologically-talented teams led by Aviv Regev (Broad Institute of MIT and Harvard) and collaborators. inCITE into How Transcription Factors Shape In Vivo Gene Expression A collaboration […]

A Youthful Brain Boost via DNA Hydroxymethylation: TET1 Enters the Myelin Repair Technician’s Toolkit

December 13, 2021

Does it feel like your aging brain cells have been firing a little slower lately? Why not refresh your connection and speed up your synaptic signal transmission with a visit from your oligodendrocyte myelin repair technicians. Their youthful TET1 and DNA hydroxymethylation repair kit will bring you back to fiber-optic speeds in no time. This […]

A Circulating microRNA Makes a Macro Difference in the Battle Against COVID-19

November 28, 2021

From holding the door open to passing on a link to an exciting epigenetics paper – small gestures can make an enormous difference to anyone’s day! Now, an exciting new study suggests that the expression of a microRNA has a macro impact during SARS-CoV-2 infection and could represent an important target for the treatment of […]

Automated Chromatin Profiling Platforms Autopilot Patients to the Clinic

November 22, 2021

From human-free supermarket check-outs to autopiloted cars, the modern world is rapidly moving towards automation. In the most recent advance, a rabble of robotic researchers has applied related technological tricks to epigenetic assays to “autopilot” high-throughput chromatin profiling and provide a clinical tool that may support optimized treatment choices in leukemia patients. Specifically, a technology-driven […]

Epigenetics Takes the Wheel as the Brain Mapping Project Gets Motoring!

October 30, 2021

It’s easy to get lost when motoring down the epigenetic landscape; thankfully, a group of cunning cartographers from the Brain Research through Advancing Innovative Neurotechnologies Initiative Cell Census Network (or BICCN for short) has generated single-cell maps to guide your voyage of the brains’ motor cortex. Although this epigenetic road trip may be too long […]

Transgenerational Epigenetic Inheritance of Horizontally-transferred Memories Goes Viral

October 4, 2021

While research into the transgenerational epigenetic inheritance went viral long ago, a new “social media” platform powered by horizontal transfer has taken “going viral” a bit too literally. In their retweetable new article, researchers from the lab of Coleen T. Murphy (Princeton University, New Jersey) now demonstrate that virus-like particles (VLPs) support horizontally-transferred memories and […]