epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Tackling Heterogeneity with DNA Methylation

February 12, 2013

Heterogeneity adds value to our culture in numerous ways, but when it comes to analyzing large-scale case/control studies with blood, heterogeneity can be more frustrating than a Rubik’s Cube. Since blood is an easy-to-get, relatively noninvasive specimen, it’s ideal for disease diagnosis and for monitoring the effectiveness of treatments. Scientists have reported that DNA methylation […]

EpiGenie Guide: ChIP Antibody Validation

February 11, 2013

If you can find a ChIP Grade or ChIP Validated antibody, then you’ve got a head start. But there’s no reason to stress if you can’t. Leave that for the data analysis part of your experiments (only kidding). A quick check of the spec sheet of any antibody can reveal lots of useful info. Here […]

The Epigenetics of Organ Transplantation

January 31, 2013

Dr. Daniel Salomon discusses the state of organ transplants, what obstacles exist, and how epigenetics might be central to improving long-term health in patients. The Challenges in Transplantation My background is in transplantation medicine, transplantation immunology. And my interests are to change the way we manage patients. There’s a huge series of challenges right […]

miRNAs that Bind Coding Sequences are Specialized for Inhibiting Translation

January 28, 2013

We all have our specialties—maybe yours is in histone modifications or maybe you can name every American Idol winner. In any case, miRNAs have some specialization too. Researchers now say that they’ve figured out what miRNAs that bind within the CDS, or coding sequence, of an mRNA do—they specialize in inhibiting translation. Most studies talk […]

MBD-SNP Analysis Shows that Prostate Cancer is Personal

January 28, 2013

These days, everyone wants to stand out. Just look at Lady Gaga and Nicki Minaj—in fact, you can’t not look at them. It turns out that metastatic prostate cancer tumors also stand out from patient to patient, as long as you know where to look. A team of Johns Hopkins researchers used methyl-binding enrichment and […]

DNA Methylation Map Based on Data from 82 Human Cell Lines and Tissues

January 21, 2013

Christmas has come and gone, but the ENCODE Project is the gift that keeps on giving. Using samples and data from ENCODE (in combo with their own data), researchers have come up with a single-base resolution map of DNA methylation across 82 human cell lines and tissues, including many cancers. With the ever increasing DNA methylation data […]

Visualize Histone Modifications in Single Cells? Yes You Can.

January 18, 2013

ChIP has been a dear friend to researchers studying histone modifications for years. But, just like most friends, it has its imperfections too, particularly when it comes to sensitivity. On its best day ChIP is about as sensitive as Mr. Trump and just like The Donald, it can be temperamental. So we were excited to […]

mRNA Alternative Polyadenylation Lifestyles Comes into Focus

January 17, 2013

As the only epigenetics media group based out of southern California, we’ve learned to be very accepting of alternative lifestyles, which is why this method caught our eye. mRNA are a diverse bunch, with all kinds of alternative polyadenylation that can affect their cellular localization and stability. RNA Seq has enabled unprecedented glimpses into the transcriptome, but […]

Making Sense of the Grade: ChIP Validation Terminology

January 17, 2013

Antibody vendors have been hard at work to offer antibodies that are suitable for applications like ChIP. Usually these antibodies have been used successfully in peer-reviewed publications. In many cases they’ve been validated internally by an R&D team, and in some cases, each lot may be validated to work in ChIP applications. The tricky part […]

MeCP2 Puts 5hmC in a Bind in Active Neuronal Genes

January 7, 2013

A good actor can play very different roles and still make you believe in the character. For example, who knew Wolverine could emote and sing, like Hugh Jackman does in Les Misérables? Just the same, it turns out that MeCP2, a protein thought to repress transcription by binding to 5mC (5-methylcytosine, actually seems to encourage […]

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Epigenetics and ncRNA Headlines

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