epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Chromatin: 2010 2nd Half Editor’s Favorites

January 6, 2011

Chromatin research keeps blowing up right along with the rest of the epigenetics field over the last six months or so of 2010. Here are some of our favorite Chromatin headlines covering things like chromatin remodeling, transcription ehancers, histone turnover and nucleosome positioning. Chromatin Remodeling The dynamics of nucleosome interactions and displacement during cellular processes […]

ncRNA: 2010 2nd Half Editor’s Favorites

January 6, 2011

2010 is over, so we’ve decided to take a look back at some of the exciting non-coding RNA work that came out over the last half of the year on topics like iPS cells, miRNA sponges, cancer and biomarkers. Enjoy! miRNAs in iPS cells An important tool for stem cell research, induced pluripotent stem cells […]

DNA Methylation: 2010 2nd Half Editor’s Favorites

January 6, 2011

DNA methylation was heating up in the second half of 2010 in hot pursuit of determining roles for 5-hydroxymethylcytosine, creating bisufite alternatives and uncovering DNAm’s role in disease. Have a look at some of our favorite articles from the last six months: 5-hmC and Stem Cells Anytime you put together a new biological role for […]

Mitotic Bookmarking – Another Epigenetic Role for Protein Methylation?

January 5, 2011

In a past contribution from CH3 BioSystems, evidence for the role of protein methylation as a key epigenetic regulator in addition to DNA methylation was described. Since protein arginine methylation can produce important direct regulatory control over gene expression, it shouldn’t be surprising that it may also play a role in mitotic bookmarking, the latest […]

You Are What Your Father Ate, Too

December 30, 2010

Several recent studies have shown that Mom’s diet at conception or during pregnancy can affect the epigenetics of her offspring. Now it’s Dad’s turn to share some of the responsibility as well. A new Cell paper by Oliver Rando at the University of Massachusetts Medical School and colleagues found that male mice fed a low-protein […]

Combinatorial Histone Interactions Put Antibodies’ Specificity in a Bind

December 24, 2010

Whether you work in Hollywood or the research labs close by at UCLA, it seems like a good set of Abs can solve most problems. Unfortunately there’s no airbrushing when it comes to ChIP. Most ChIP antibodies are pretty good at recognizing the specific histone modification they were raised against, as a couple of recent […]

Small Pores Provide Smoother 5-hmC Experience

December 16, 2010

Small pores aren’t just highly sought after in the cosmetics industry. They can really lend a hand in smoothing out the rougher epigenetics experimental challenges researchers face nowadays. Just ask Dr. Meni Wanunu and Marija Drndic at the University of Pennsylvania, along with colleagues from New England Biolabs, Boston University, and Temple University, who put […]

miR-200a Takes Down Cancerous Stem-like Transition

December 15, 2010

There’s been a deafening buzz lately surrounding a new focus of epigeneticists known as the epithelial-mesenchymal transition (EMT). EMT, the gateway between normal epithelial cells and those that gain mesenchymal properties, is thought to be the point where cancer metastasis kicks off. And now a University of Hong Kong team, led by Hongping Xia reports […]

SILAC Offers a New Twist on Histone Turnover

December 15, 2010

A new technique has arrived on the scene that makes life a little easier for those of you into studying histone turnover rates. Taking advantage of technologies used by our friends in proteomics, researchers at Princeton University explored the turnover of various histone proteins and how post-translational modifications (PTMs) alter the speed of that process. […]

Enriching 5-hmC Detection with Sugar

December 15, 2010

In today’s more health conscious world, we’ve seen a surge in organic-everything. Enriching anything with sugar is a definite no-no. Good thing researchers play by their own rules. A University of Chicago research team led by Chuan He recently enriched the latest entrant to DNA methylation marks, 5-hmC, by enriching with glucose in a really […]

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Epigenetics and ncRNA Headlines

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