epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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A Great Start to RNA-Seq: Zymo Research’s RNA Clean & Concentrator™-5

July 1, 2013

With every high-tech advance in the methods used for RNA analysis , the need for extremely pure RNA input samples becomes even more crucial. The RNA Clean & Concentrator™-5 (RCC™-5) Kit from Zymo Research packs high-performance into a fast and easy format that enables even the most demanding methods, including RNA-Seq. RNA Clean and Concentrator™-5 […]

The Darkside of Epigenetic Plasticity

June 26, 2013

Sure, genes get mutated in cancers, but the epigenome gets messed-up too. In fact, two researchers argue in a recent review that a “dysregulated epigenome” that’s too plastic and flexible could itself lead to cancer. Andrew Feinberg and Winston Timp, both from the Center for Epigenetics at the Johns Hopkins School of Medicine, wrote the […]

Webinar: Lighting up the Dark Matter of the Genome – Unravelling the Roles of Non-Coding DNA in Disease and Development

June 26, 2013

Dr. Marcel Dinger, PhD discusses some of the most recent findings that shed light on non-coding RNAs in the genome. **this webinar is no longer available** Abstract Approximately 98% of the human genome comprises noncoding DNA, the function of which is largely unknown. Intriguingly, more than 85% of single nucleotide polymorphisms identified to be associated […]

Keeping Up with Live Cell DNA Looping

June 25, 2013

The reality TV era has made voyeurs of us all. So it makes sense that we’d want to take a peek inside live cells too. Now comes a report of a new method that shows, for the first time, DNA getting loopy inside live E. coli cells. Johns Hopkins University Med School researchers say that […]

DeepSAGE Digs up Expression Differences in 3’ Ends

June 24, 2013

It isn’t always a good thing to get the end of something, but researchers say that by grabbing onto 3’ ends of transcripts and tagging them, DeepSAGE digs deep, getting low-level transcripts and getting new info on their “back-ends.” That could be important for figuring out exactly how gene expression changes with disease. “It was […]

HDAC-Glo™ Brightens up HDAC Activity Screening

June 21, 2013

Histone Deactylase (HDAC) researchers have been clamoring for more sensitive and reliable HDAC assays in order to generate the high quality data that previous techniques don’t always deliver. The HDAC-Glo™ I/II Assays and Screening Systems from Promega aim to shine new light on the matter with highly sensitive assays that ditch the old, troublesome false […]

RIP-Seq Shows miRNA Expression and Function Not Always a Match

June 20, 2013

There is a saying that, “each microRNA can have hundreds of target mRNAs, and each mRNA can be targeted by hundreds of miRNAs”. If that’s true, then how the heck are we supposed to know what’s going on in that crazy transcriptome? What does it mean when a miRNA and predicted target don’t explain the […]

Application Note: Automated Bisulfite Conversion

June 14, 2013

Unlike more mainstream assays, bisulfite conversion approaches have been dependent on manual manipulation of spin plates and columns or have been of limited throughput. By adapting the clean-up of bisulfite converted DNA to a magnetic bead based procedure and coupling it to the Freedom EVO® platform, Zymo Research has opened the door to high-throughput bisulfite […]

Optical Detection Adds Color to 5hmC Analysis

June 11, 2013

A talented crew of researchers led by Dr. Yuval Ebenstein (Tel-Aviv University, Israel) recently pioneered a technique that gives anyone the ability to assay 5hmc “nanodrop” style. In their paper, they presented proof-of-principle experimentation. They labeled DNA and then sandwiched it between two glass slides to stretch it.. The DNA was then imaged on a […]

The Consequences of RNAs Alternative Polyadenylation Lifestyle

June 7, 2013

First it started enjoying the ‘occasional’ methylation. Then it crossed the LINE when it ‘borrowed’ its good buddy’s machinery. And now it seems like RNA just can’t stop. It turns out that just like all those hipsters, splicing isn’t the only one to enjoy an ‘alternative’ lifestyle. Researchers from UCLA have shown that polyadenylation wants […]

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