epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Homocysteine Gives Sneak-Peak into Low Birth Weights

November 19, 2010

Were you a tiny tot or a tubby toddler? If so, your mom’s folic acid intake could be to blame. As those of us in the U.S. prepare to indulge in a Thanksgiving Day gorge-fest, here’s more proof that we are what our mothers ate. A recent study by William Farrell and colleagues in the […]

miR-23a,27a,24-2 Cluster is Bad to the Bone

November 19, 2010

We’re not calling the miRNA 23a,27a,24-2 cluster a bunch of biological bad-guys, but if you’re a progenitor cell hoping to one day become an osteoblast, then they aren’t exactly your best friends. A new study reveals that the miRNA 23a,27a,24-2 cluster is at the center of a regulatory network that controls osteoblast differentiation. The new […]

DNA Methylation Affinity Methods Come With Some Baggage

November 19, 2010

If you sometimes wonder about the quality of data coming from today’s popular affinity-based DNA methylation analysis methods, you‘re not alone. In fact, researchers at Garvan Institute of Medical Research in Sydney Australia decided to do something about it by studying the techniques and learning that methylated DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain-based capture […]

Epimutation: The New Risk Factor on the BRCA1 Block

November 18, 2010

BRCA1, (breast cancer susceptibility gene 1), is involved in repairing damaged DNA or destroying cells when the DNA is beyond repair. Women with mutations in the BRCA1 gene have a predisposition to developing breast and ovarian cancer. OK, that wasn’t necessarily a newsflash, but wait… EpiGenie reader, Alexander Dobrovic and his team at the Peter […]

Stem Cells Heartbroken Without miR-499

November 8, 2010

How can you mend a broken heart? Well if researchers at Stanford University are right, then one day all you’ll need are some stem cells and miR-499 to cure a bad case of heartache (well, at least the kind that follows a heart attack. The bad breakup kind will still be up to relationship experts […]

Nucleosome Positions Are Cloudy With Chance of Stability

November 5, 2010

It’s all about perspective. Like a funhouse mirror that makes you look fat or skinny depending on how it’s curved, it seems there’s some controversy on the subject of nucleosome positioning based on how results get interpreted. So, are nucleosomes stable or do they move around? In this contributed piece, Istvan Ladunga from the University […]

Prions Take Epigenetics to the Extreme

October 28, 2010

Yeah, we know that somewhere between the X-games and base-jumping light beer ads, the term “Extreme” got a little played out. But, in their Perspective piece in Science, Randal Halfmann and Susan Lindquist make the case that certain proteins with unique folding properties, called prions, deserve the “extreme” label. Prions are proteins that are stably […]

Pardon the Epigenetic Disruption

October 28, 2010

One of the great things about stem cells is how they seem to do just about anything. These days, stem cells have more Apps than an iPad, and in the new issue of Science we find one more: using stem cells to screen for “epigenetic disruptors”. The proposed idea is to use the built-in developmental […]

That’s Sweet: Tracking Down 5-hmC with Sugar

October 26, 2010

To say researchers have been pretty amped about 5-Hydroxymethylcytosine (5-hmC) this last year would be an understatement. Is this 6th base for real, or is it some kind of intermediate of it’s more abundant cousin 5-mC? So far its low key presence has been detected in embryonic stem cells, brain, and other organs but there […]

Take a Look: NCBI Epigenomics Sample Browser

October 26, 2010

Our friends at the NCBI clued us in to one of their newest free tools that should prove to be a big help to anyone wanting to sort through next-gen sequencing data from epigenomic studies. NCBI’s new Sample Browser, located on its Epigenomics page, lets users search, access and analyze sequencing data from various publicly […]

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