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Epigenetics and ncRNA Headlines

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Naughty and Nice ChIP Antibodies

December 9, 2010

With Santa’s yearly gift giving spree fast approaching, kids everywhere are on their best behavior to avoid ending up on the “naughty list.” A consortium of chromatin researchers found out which ChIP antibodies are naughty or nice, by testing a ton of commercial antibodies raised against 3 histones with 57 different modifications in flies, worms, […]

COLDAIR Kicks Off Histone Methylation Prep for Winter

December 2, 2010

As winter winds turn our noses into Rudolph lookalikes, flowering plants get busy at the epigenetic level. At the onset of winter, plants in temperate regions, such as Arabidopsis thaliana, undergo a process called vernalization where they prep to quickly flower once spring rolls back around. As Jae Bok Heo and Sibum Sung at the […]

Webinar: Chromatin Immunoprecipitation-Improved Approaches for the Analysis of Epigenetic Regulation at Single Loci and Genome-Wide

December 1, 2010

This 50 minute presentation covers the basic concepts of ChIP and advances in technology, including genome-wide profiling. You’ll learn approaches to assay design, performance, and data analysis to help avoid the most common and some uncommon experimental pitfalls. Chromatin Biology Research and Development, EMD Millipore Presenter: John M. Rosenfeld, Ph.D. Format: Audio with Synchronized Slides, […]

H3K27ac Marks the Spot of Active Enhancers

December 1, 2010

News media always seem to focus on the negative . . . war, violence, men wearing kilts sans underwear through airport security lines on National Opt-Out Day. The same can be said about genetic elements that regulate transcription: the repressors seem to get all of the attention. Part of the reason is that enhancers are […]

Leukemia ALL Because of microRNA-125b

November 30, 2010

In a courtroom drama, sometimes the facts are so cut and dried that the defendant’s fate is all but sealed. New research from Marina Bousquet, a Lodish lab member at the Whitehead Institute, makes a strong case that miR-125b is essentially a smoking gun that causes leukemia. miR-125b is overexpressed in several different types of […]

Behind the Scenes Histone and DNA Methylation Regulation Tricks Revealed

November 30, 2010

Diehard fans cinema aren’t satisfied by just watching a movie; they want to know everything about it, including how those amazing special effects are pulled off. In much the same way, scientists at the University of Bergen in Norway noticed extensive gene expression reprogramming in their experiments with pre-cancerous prostate cells and wanted to get […]

Homocysteine Gives Sneak-Peak into Low Birth Weights

November 19, 2010

Were you a tiny tot or a tubby toddler? If so, your mom’s folic acid intake could be to blame. As those of us in the U.S. prepare to indulge in a Thanksgiving Day gorge-fest, here’s more proof that we are what our mothers ate. A recent study by William Farrell and colleagues in the […]

miR-23a,27a,24-2 Cluster is Bad to the Bone

November 19, 2010

We’re not calling the miRNA 23a,27a,24-2 cluster a bunch of biological bad-guys, but if you’re a progenitor cell hoping to one day become an osteoblast, then they aren’t exactly your best friends. A new study reveals that the miRNA 23a,27a,24-2 cluster is at the center of a regulatory network that controls osteoblast differentiation. The new […]

DNA Methylation Affinity Methods Come With Some Baggage

November 19, 2010

If you sometimes wonder about the quality of data coming from today’s popular affinity-based DNA methylation analysis methods, you‘re not alone. In fact, researchers at Garvan Institute of Medical Research in Sydney Australia decided to do something about it by studying the techniques and learning that methylated DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain-based capture […]

Epimutation: The New Risk Factor on the BRCA1 Block

November 18, 2010

BRCA1, (breast cancer susceptibility gene 1), is involved in repairing damaged DNA or destroying cells when the DNA is beyond repair. Women with mutations in the BRCA1 gene have a predisposition to developing breast and ovarian cancer. OK, that wasn’t necessarily a newsflash, but wait… EpiGenie reader, Alexander Dobrovic and his team at the Peter […]

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