epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Priming Cancer Therapies with Epigenetics with Dr. Peter Jones

September 9, 2013

Dr. Peter Jones of the Norris Comprehensive Cancer Center at USC discusses the positive impact epigenetic therapies are having in the clinic. Priming Cancer Therapies with Epigenetics with Dr. Peter Jones Well, I think the thing that excites me the most is the increasing successes of epigenetic therapies in the clinic. And so I […]

Decoding the Molecular Mechanisms of lncRNA XIST

September 6, 2013

Fast on the heels of a major epigenetic engineering breakthrough revealing that XIST can help treat the symptoms of Down’s syndrome, Dr. Carolyn Brown (University of British Columbia) and crew sought to find out exactly what’s going on at the molecular level with this complex lncRNA. Their experimentation started with they hypothesis that “long ncRNAs […]

Stem Cell Conference Highlights Timeline

September 4, 2013

Stem Cells are a hot topic these days. Here we provide a history of epigenetic breakthroughs in this interdisciplinary field as told through our Conference Coverage.

Genome-wide and Gene-specific Analysis of DNA Methylation

September 3, 2013

EpiGenie recently reviewed the text Epigenetics by Jorg Tost. Here is a more in depth summary of one the chapters provided courtesy of JA Gill who is a molecular biologist at NOAA in the Northwest Fisheries Science Center, to give you a little sneak peek into what the whole book is all about: Methods for […]

One Man’s Junk DNA is Another’s Intronic microRNA

September 3, 2013

Introns have a bad rap these days. Sequestered with the rest of the (epi)genome in the term ‘junk’ DNA’; A reductionist way of describing 95% of our beloved genome as useless. But as new evidence keeps pointing out, introns and ‘non-coding’ regions actually code for most of the genomes products and/or function. In recently published […]

RRBS and 450k Arrays Face Off Over DNA Methylation Analysis

August 27, 2013

DNA methylation has been a cornerstone of epigenetics research from the start, and the emergence of technologies that make investigation of the modification more accessible has only made the DNA methylation field even hotter. Several tools and techniques are available to assess DNA methylation levels, but two in particular, reduced representation bisulfite sequencing (RRBS) and […]

Webinar: Life Long Changes in DNA Methylation & ncRNAs in Fetal Alcohol Syndrome (FAS)

August 22, 2013

Western University’s Ben Laufer (Ph.D. Candidate) discusses how bioinformatic software was used to establish that even moderate exposure to alcohol during pregnancy, equivalent to a few beers every now and then, can produce profound and heritable variations in development, behaviour, and learning that are maintained in the exposed fetus for a lifetime by altered epigenetic […]

R-loops: RNA-DNA Hybrids Making Noise on Silenced Genes

August 21, 2013

Prader-Willi syndrome and Angelman syndrome are like two-peas-in-a-pod, the textbook cases of the power of genomic imprinting. However, some consider them to be distinct genetic disorders that are grouped together, as Dr. Janine LaSalle (UC Davis) puts it; “Only because of the shared chromosomal location of deletions to 15q11-13 and ‘quirky’ oppositely imprinted inheritance patterns.” […]

MECP2 Therapy Deployed to Reverse Rett Syndrome Symptoms

August 21, 2013

They say that cats have nine lives. If that’s true then the idea of ‘Gene Therapy’ must be part feline. Despite several hurdles over the years, gene therapy once again captured the spotlight; this time by demonstrating that replacing mutated MECP2 can reverse the symptoms of Rett Syndrome in mice. The new research led by […]

Genomic Editing and lncRNAs Team Up Against Down’s Syndrome

August 20, 2013

According to breakthrough research, families affected by Down’s Syndrome may one day have the opportunity to alleviate many of the syndrome’s harmful aspects. Regardless of the ethical concerns around this treatment, which we won’t debate here, we think just the approach and mechanism developed within this study are worthy of a shout out. A cunning […]

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