epigenetics

Epigenetics and ncRNA Headlines

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A Pack of Hyenas Gets the Last Laugh: Early Social Networks Change DNA Methylation and Adult Stress Indicators

August 1, 2021

Ever wonder what that pack of hyenas is laughing about? Well, it may just be your social status. But don’t stress over it too much, because they’ve given us a truly wild idea in this DNA methylation marvel: Having more friends and spending more time with them in early life makes for less stress at […]

Selfies from Beyond the Grave: CelFiE Deconvolutes Cell-free DNA Methylation Messages

July 27, 2021

Although receiving a selfie from beyond the grave might sound disturbing, posthumous snapshots from dying cells in the form of the cell-free DNA (cfDNA) they release can help prevent us from entering an early grave. Giving Snapchat a run for its money is a new program called CelFiE (CELl Free DNA Estimation via expectation-maximization), which […]

Single-cell Multi-omics of the Immune Response to Vaccination

July 26, 2021

A recent viral study revealed that SARS-CoV-2 infection alters chromatin accessibility in our all-important immune cells to facilitate immune memory – but does the same apply to vaccination? To answer this somewhat flu-mmoxing question, a flu-id force of epigeneticists led by Bali Pulendran (Stanford University, California) utilized single-cell multi-omics to explore the effects of influenza […]

Getting Cheeky with Buccal Collection Methods: The Swab vs. Saliva Cellular Heterogeneity Showdown

July 23, 2021

There’s nothing tongue in cheek when it comes to the consideration of buccal cell heterogeneity in sample collections methods. Although buccal epithelial cells are the target given their relationship with the brain DNA methylome, immune cells come along for the ride. As the lab of Jeffery Craig (Deakin University, Australia) has previously shown, buccal epithelial cell sample collection […]

An Oliver’s Twist on an Old Tale: Orphan CpGs Will Have You Asking for More

July 17, 2021

Move over Oliver Twist, there’s a new orphan in town to satisfy our hunger for stories of DNA methylation. Two new tales of orphan CpGs help them find a home in our hearts and epigenomes through the application of cutting-edge epigenomics techniques and genetic engineering to embryonic stem cells and neuronal cells. Making the Right Connections: […]

It’s Nature versus Nurture in an Epigenetic Rejuvenation Face-off!

July 15, 2021

The age-old battle of nature versus nurture has entered new frontiers with two exciting studies exploring different mechanisms that drive “epigenetic rejuvenation” – also known as the science of how our old and creaky DNA methylation-based epigenetic clocks can be wound back into a frolicking and fancy-free state. Together, these studies demonstrate the two faces […]

Environmental Fountain of Youth: Enrichment Prevents Aging-Induced DNA Methylation Changes

July 15, 2021

A restricted diet, regular exercise at the gym, not drinking too much… Acts of deprivation and suffering are supposed to guide us on our quest to the foundation of youth. Thankfully, exciting new epigenetic findings show us that it’s time to learn a lesson from the hedonists by demonstrating how environmental enrichment protects us from […]

A Fishy Tale of Intergenerational Epigenetic Inheritance of DNA Methylation in a Foul Environment

July 5, 2021

Although the impact of toxic exposure on our epigenome can leave a bad taste, a recent study into hydrogen sulfide transcends the senses by hitting the smell category too. Building on their previous fishy tale of transgenerational epigenetic inheritance, the lab of Michael K. Skinner (Washington State University, Pullman, WA, USA) recently explored a new species […]

Single-Cell ATAC-seq Shows that Chromatin Remodeling Allows Immune Cells to Remember COVID-19

June 24, 2021

While few will remember the last eighteen months with any great fondness, the memory of our immune cells represents a critical facet controlling long-lasting responses induced by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and exposure to vaccines. In an unforgettable study, researchers led by Liang Chen, Mark M. Davis, and Pengyuan Yang now demonstrate […]

An Inclusive EWAS Filters Through the Trans-ethnic and Ethnic-specific DNA Methylation Profiles of Kidney Function

June 11, 2021

Diversity and inclusion are important components of our modern society, and epigenomics is no exception. To build on our knowledge of ethnic differences and similarities, an inclusive epigenome-wide association study (EWAS) of kidney function has come forth to filter the hits. A group led by Charles Breeze (National Cancer Institute) and Nora Franceschini (University of North Carolina) conducted […]

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Epigenetics and ncRNA Headlines

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