epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Non-Coding (RNA) Doesn’t Have to Mean Non-Sense

October 14, 2009

Our understanding of non-coding RNAs has ramped up like a quarter pipe at the X Games over the last several years and, if recent publications are any indication, we’ve only scratched the surface. The realization that just a sliver of our vast transcriptomes is protein-coding, much of it is churned out in both directions, and […]

Epigenetic Cancer Therapy – Not Just for DNA Anymore

October 14, 2009

Researchers studying cancer epigenetics therapies dream of days when we might be able to control DNA methylation like our car stereos…less treble, little more bass. 5 Aza is one of the early leaders in the epi pipeline, and like a lot of therapeutics out there, we learn more about how it impacts other cellular processes […]

The Emerging Players in the Epigenetics of Hypoxia

October 14, 2009

Even beyond its most obvious consequence – death — oxygen deprivation has profound effects on cells and tissues. A couple of recent papers highlight some connections between epigenetics and hypoxia. Anaerobic respiration is great for brewing beer. But add O2 and the yeasty beasties stop fermenting. It’s the same principle – only in reverse – […]

The First Completed DNA Methylomes Cover All the Bases

October 14, 2009

Halfway into October, we’re deep into post-season baseball. Although, the Padres haven’t given us local San Diegans much to boast about this year (or last), local standouts at the Salk Institute and UCSD knocked one out of the park this week in Nature. Here’s a team that really knows how to cover the bases, all […]

ChIP-Seq Analysis: May All Sequences Be Treated Equal

October 14, 2009

“All men are created equal” is one of the most famous phrases in U.S. politics, but it took a while for this concept to be adopted by researchers dealing with repetitive sequences during ChIP-Seq analysis. The short length of individual deep sequencing reads creates some sequence runs that don’t map to a unique loci on […]

Putting Epigenetics on the Map

October 12, 2009

Between the mapping centers, generating enormous quantities of data for the NIH Roadmap Epigenomics Initiative, and the NCBI that is archiving and distributing it, lies the Epigenomics Data Analysis and Coordination Center. Aleksandar Milosavljevic and co-PI Arthur Beaudet won the 5-year, $7+ million U01 grant last year to set up and run the EDACC informatics […]

Raising the Bar on ChIP Antibody QC

October 1, 2009

Nowadays, we still find antibodies at the core of many key lab techniques, but there’s a big difference in what’s going on downstream of the IP today. A few years ago researchers were looking at varying shades of grey on a gel; a gel that didn’t eat up too much grant money. Now, the downstream […]

Small RNA Sequencing Adds Color(Space) to miRNA Dynamics in Stem Cell Regulation

October 1, 2009

For the last few years, stem cell researchers have been intrigued by miRNAs’ Houdini-esqe disappearing act as stem cells embrace their fate. Add in evidence showing how knocking out endogenous miRNA machinery like Ago2 can really add a few kinks to proper neural development and you get a stem cell community that’s fired up to […]

BayesPeak Analysis Ups Your ChIP-Seq Game

October 1, 2009

Proteins have been binding DNA for some time now, but only recently has ChIP-Seqencing (ChiP-Seq) pointed exactly where. As the technique becomes more popular, more researchers are wondering; what’s the best way to analyze the mounds of data they’ve just created with their ChIP-seq experiments? To tackle this problem, a group of bioinformaticians from the […]

A Tangled Web We Weave When We Practice to Regulate

September 10, 2009

We’ve all seen them hanging on the freezers and filling otherwise empty wall space in labs–signal transduction maps that look like abstract artwork. They’re enough to make even the most dedicated researcher wonder if there’s light at the end of the tunnel. As difficult as it is to make sense of complex transcriptional cascades, generating […]

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Epigenetics and ncRNA Headlines

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