epigenetics

Epigenetics and ncRNA Headlines

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Stem Cells Heartbroken Without miR-499

November 8, 2010

How can you mend a broken heart? Well if researchers at Stanford University are right, then one day all you’ll need are some stem cells and miR-499 to cure a bad case of heartache (well, at least the kind that follows a heart attack. The bad breakup kind will still be up to relationship experts […]

Nucleosome Positions Are Cloudy With Chance of Stability

November 5, 2010

It’s all about perspective. Like a funhouse mirror that makes you look fat or skinny depending on how it’s curved, it seems there’s some controversy on the subject of nucleosome positioning based on how results get interpreted. So, are nucleosomes stable or do they move around? In this contributed piece, Istvan Ladunga from the University […]

Prions Take Epigenetics to the Extreme

October 28, 2010

Yeah, we know that somewhere between the X-games and base-jumping light beer ads, the term “Extreme” got a little played out. But, in their Perspective piece in Science, Randal Halfmann and Susan Lindquist make the case that certain proteins with unique folding properties, called prions, deserve the “extreme” label. Prions are proteins that are stably […]

Pardon the Epigenetic Disruption

October 28, 2010

One of the great things about stem cells is how they seem to do just about anything. These days, stem cells have more Apps than an iPad, and in the new issue of Science we find one more: using stem cells to screen for “epigenetic disruptors”. The proposed idea is to use the built-in developmental […]

That’s Sweet: Tracking Down 5-hmC with Sugar

October 26, 2010

To say researchers have been pretty amped about 5-Hydroxymethylcytosine (5-hmC) this last year would be an understatement. Is this 6th base for real, or is it some kind of intermediate of it’s more abundant cousin 5-mC? So far its low key presence has been detected in embryonic stem cells, brain, and other organs but there […]

Take a Look: NCBI Epigenomics Sample Browser

October 26, 2010

Our friends at the NCBI clued us in to one of their newest free tools that should prove to be a big help to anyone wanting to sort through next-gen sequencing data from epigenomic studies. NCBI’s new Sample Browser, located on its Epigenomics page, lets users search, access and analyze sequencing data from various publicly […]

Chromatin Remodelers In Search of Mr. Right

October 26, 2010

For the first time, the molecular machines known as “chromatin remodelers” have been found to spend much of their time rapidly searching for their nucleosome soulmates. And, just like desperate singles at a Speed Dating party, they keep at it until they find the right one. Chromatin remodelers help organize the genome, control DNA accessibility, […]

The miRNA Trade Deficit in Cancer

October 25, 2010

Balancing imports and exports can be a tough task for any entity. It turns out cancer cells have a major issues when it comes to exporting pre-miRNA between the nucleus and cytoplasm that can have a pretty nasty impact on cellular homeostasis. miRNA expression profiles in tumors typically show a down regulation of miRNA expression. […]

Comparative Epigenomics Branches Out

October 19, 2010

When you’re comparing epigenomes, it’s easy to miss the forest for the trees. Because the epigenetic “fruit” on each nucleotide can vary with factors like cell type, differentiation state, and the environment, it’s often tricky to spot patterns on the epigenome-wide scale. In a recent Nature Biotechnology commentary, Aleksandar Milosavlijevic of the NIH Epigenomics Roadmap […]

How to Tame the Methylome

October 18, 2010

So many ways to analyze genomic DNA methylation, so little time (and money). With so many choices available these days it’s not easy to figure out the best method to use for methylome studies. A new survey of two Nature Biotechnology papers by Stephan Beck from the UK’s University College London puts together the vital […]

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