epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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ChIP-Seq Analysis: May All Sequences Be Treated Equal

October 14, 2009

“All men are created equal” is one of the most famous phrases in U.S. politics, but it took a while for this concept to be adopted by researchers dealing with repetitive sequences during ChIP-Seq analysis. The short length of individual deep sequencing reads creates some sequence runs that don’t map to a unique loci on […]

Putting Epigenetics on the Map

October 12, 2009

Between the mapping centers, generating enormous quantities of data for the NIH Roadmap Epigenomics Initiative, and the NCBI that is archiving and distributing it, lies the Epigenomics Data Analysis and Coordination Center. Aleksandar Milosavljevic and co-PI Arthur Beaudet won the 5-year, $7+ million U01 grant last year to set up and run the EDACC informatics […]

Raising the Bar on ChIP Antibody QC

October 1, 2009

Nowadays, we still find antibodies at the core of many key lab techniques, but there’s a big difference in what’s going on downstream of the IP today. A few years ago researchers were looking at varying shades of grey on a gel; a gel that didn’t eat up too much grant money. Now, the downstream […]

Small RNA Sequencing Adds Color(Space) to miRNA Dynamics in Stem Cell Regulation

October 1, 2009

For the last few years, stem cell researchers have been intrigued by miRNAs’ Houdini-esqe disappearing act as stem cells embrace their fate. Add in evidence showing how knocking out endogenous miRNA machinery like Ago2 can really add a few kinks to proper neural development and you get a stem cell community that’s fired up to […]

BayesPeak Analysis Ups Your ChIP-Seq Game

October 1, 2009

Proteins have been binding DNA for some time now, but only recently has ChIP-Seqencing (ChiP-Seq) pointed exactly where. As the technique becomes more popular, more researchers are wondering; what’s the best way to analyze the mounds of data they’ve just created with their ChIP-seq experiments? To tackle this problem, a group of bioinformaticians from the […]

A Tangled Web We Weave When We Practice to Regulate

September 10, 2009

We’ve all seen them hanging on the freezers and filling otherwise empty wall space in labs–signal transduction maps that look like abstract artwork. They’re enough to make even the most dedicated researcher wonder if there’s light at the end of the tunnel. As difficult as it is to make sense of complex transcriptional cascades, generating […]

miRNA Regulatory Documentary Bonus Footage: Featuring XRN-2

September 10, 2009

Most miRNA plots we follow share a similar climactic ending: miRNA inhibits this, in this condition, in response to this. Don’t get us wrong. We can read about miRNA regulation all day, which is good because we often do, but do you ever wonder what happens to miRNAs after they’ve locked their target, and put […]

Getting RIPped: miRNA Target ID Workout Delivers

September 9, 2009

As former bodybuilder turned California Governator, Arnold Schwarzenegger, once said, “Great abs are made in the kitchen…” That may be, but when it comes to epigenetics research, great abs are made by great labs and suppliers, and they’re put to work in immunoprecipitation applications like RIP Chip. Recently, Anke van den Berg and colleagues at […]

Sorting Out Epigenetic Marks Nanostyle

September 7, 2009

Cornell molecular geneticist Paul Soloway wants to know where epigenetic marks coincide – and not just in which patients, or in which tissues, or even in which cells, but on which individual stretches of chromatin. He and co-PI Harold Craighead, an engineering physicist at Cornell, have an Epigenomics Roadmap grant that will help them find […]

Chromatin Structure: More Biasing Than A Political Talk Show

August 26, 2009

If you watch television news these days, you can spot bias a mile away. Well, we can’t do much about shoddy journalism, but a new report from scientists at UC Berkeley, led by Michael Eisen, calls attention to some bias we can fix; the kind caused by the structure of chromatin in ChIP experiments. The […]

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