epigenetics

Epigenetics and ncRNA Headlines

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SSSavi: Savvy Epigenome Editing with Diverse, Orderly Teams

December 12, 2023

Bringing in the right combination of people with different perspectives and abilities can take a team to new heights. And just like that savvy diverse team, a new epigenome editing tool called the Spy-Snoop-Sun-Avi (SSSavi) system recruits diverse effector molecules in an interchangeable and orderly way to understand how combinations of DNA and histone modifications […]

DNA Methylation Analysis Shows How Cannabis Exposure Increases the Risk of Adverse Health Outcomes

December 11, 2023

Do not risk missing a new paper describing a recent trans-ancestry epigenome-wide association study (EWAS) highlighting the significant health risks of recreational cannabis! In a fascinating new study, researchers now reveal that cannabis exposure can impact DNA methylation levels at specific regions independent of cigarette smoking to increase the risk of adverse health outcomes. Risk-averse […]

Messing Up Methylation: Formaldehyde is a Targeted Bull in a China Shop

November 27, 2023

Just like a bull in a china shop, formaldehyde (FA) was thought to damage almost everything it bumped into. But new research shows that it’s a lot more targeted, and it really likes proteins involved in DNA methylation. Sure, FA can preserve brains in jars, but it’s most often used in consumer products like glues and […]

A Super-specific Epigenetic Editing Strategy Silences Disease-associated Dominant Mutations

November 22, 2023

Is it a bird? Is it a plane? No, it’s a “super” new study that combines the strength, ability, and ingenuity of epigenetic editing to shut down our nemesis – the disease-associated dominant mutation – while leaving the innocent bystander allele unharmed! Epigenetic superheroes led by Albert Jeltsch (University of Stuttgart) aimed to battle their […]

The Brain Cell Census: A Deeper Epigenomic Understanding of the Mammalian Mainframe

November 13, 2023

If you have epigenetics on the brain like us, concentrate your mammalian mainframe on the recently published marvels on the brain’s epigenome from the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative – Cell Census Network (BICCN). Recent work brought together under the guise of the Brain Cell Census now reports on the examination […]

Differential Methylation Data Are Quick, Easy, and Inexpensive with FML-seq

November 7, 2023

Sometimes you just want to get straight to the point. Along those lines, FML-seq (fragmentation at methylated loci and sequencing) cuts to the chase by providing a quick look at differential methylation data without the labor and expense of other approaches. Granted, some methods like whole-genome bisulfite sequencing (WGBS) tell you where every methylation event is, […]

5hmC Stands Apart from 5mC Through Single-Cell Multi-omic Methods

October 23, 2023

Sometimes, you really want to stand out from the crowd. For years, 5-hydroxymethylcytosine (5hmC) has lurked in the shadows, often lumped together with 5-methylcytosine (5mC). However, these modifications have different effects—5mC generally turns down expression and 5hmC ramps it up. Sure, several methods can tease apart 5mC and 5hmC, but they require a lot of sample […]

Kacme: A New Histone Modification Couples Methylation and Acetylation to Mark Active Transcription

October 23, 2023

Some couples seem unlikely, yet somehow, they work (a recent pop star-football player pair comes to mind). Now, an even more surprising couple—a methyl group and an acetyl group—hanging out together on the very same lysine residues on histone H4s has just been spotted across species and appears to be involved in active transcription. Mind. […]

eBook: RNA & Transcriptomics

October 13, 2023

Analysis of the working of our RNA, from transcription and splicing to translation, began in a simpler time – when we talked about “RNA” and hadn’t yet recognized the whole range of RNA species, including miRNAs, ncRNAs, and more. These days, we are learning as much about the epigenetic modification of RNA and the role […]

Epigenetic Inheritance During DNA Replication: A State Lying Somewhere Between Symmetry and Instability

October 2, 2023

Emerging research has provided evidence for the critical importance of the inheritance of epigenetic states, whether that be DNA methylation, histone modifications, or even non-coding RNAs. Now, three recent studies focusing on the mechanism involved in passing down this information from parental to daughter cells while they replicate their DNA and divide in vitro provide […]

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