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Epigenetics and ncRNA Headlines

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H3K27ac Histone Acetylome-Wide Association Study Enhances our Knowledge of Alzheimer’s Disease Brain

October 30, 2018

When it comes to the complex disorders associated with aging, our knowledge could always use some enhancement. Thankfully, a new histone acetylome-wide association study (HAWAS) of H3K27ac establishes that this mark of active enhancers can also enhance our knowledge of Alzheimer’s disease (AD). The role of histone acetylation in healthy aging and AD has begun […]

A Microbiome-Sensitive H3K4me3 Profile Predicts Intestinal Inflammation in Crohn’s Disease

October 30, 2018

While our microbiome serves up the metabolites required for our histone modifications, new findings establish that this agglomeration of microorganisms can also serve up a dish most foul; one that induces a severe type of inflammatory bowel disease (IBD) known as Crohn’s disease. Although studies have established a link between alterations to the microbiome and […]

New Enzymatic Bisulfite Alternative ACEs the Competition

October 30, 2018

Sodium bisulfite is the undisputed king of DNA methylation research; and this king has been played over and over for years now. But a lot of players in the field are looking for something better, and the only thing that can trump a king is an ace, in this case ACE-seq. The active enzymatic demethylation […]

Twins R A Help for Studying Methylation in Rheumatoid Arthritis

October 9, 2018

If you think the best thing about being an identical twin is pulling off great pranks in school, think again. Identical (monozygotic) twins can also use their powers for good. The lab of Jane Worthington (University of Manchester, UK) has harnessed the power of twins to examine DNA methylation in Rheumatoid Arthritis (RA). Because RA […]

Colossal New Roadmap Study Provides Single-Chromosome View on Sequence-Dependent Allele-Specific Methylation

October 7, 2018

Colossal, gigantic, mammoth, immense; none of these adjectives appropriately describes the amount of research carried out or curated by the National Institute of Health Roadmap Epigenomics Mapping Consortium, whose final goal is to produce a public resource of human epigenomic data to drive forward basic biology and disease-oriented research. As part of this research, scientists […]

Not Just Monkey Business: circRNAs are Dynamic in the Aging Non-Human Primate Brain

September 28, 2018

While we tend to grow out of monkey business and running in circles as we grow older, exciting new profiles of brain circular RNA (circRNA) dynamics during normal aging have emerged thanks to these two youthful tactics. This insightful research into non-human primates comes from the groups of Jiali Li (University of the Chinese Academy […]

Recycling: Keeping the Planet Green and the Histone Modification Landscape Pristine!

September 22, 2018

Recycling represents one of the most important strategies to keep the planet clean and green for generations to come. Used paper, metal, and plastic and other assorted detritus generally encounter a second use, but can we recycle the histone proteins that help to package our DNA and maintain cell-type-specific transcriptional programs? A lean, clean, and […]

Forget a Moment on the Lips, DNA Methylation Disruptions from a Night Without Sleep Could Mean ‘Forever’ on the Hips

September 20, 2018

While staring at the alarm clock isn’ta great way to catch a healthy night’s sleep, the lull of our circadian rhythm most certainly is. The circadian clock keeps our cells and their epigenomes in shape by maintaining synchrony with the day, and now new findings from the lab of Christian Benedict at Uppsala University (Sweden) […]

To Bee or Not to Bee Queen: The Role of Chromatin Structure in Honey Bee Caste Determination

September 2, 2018

We’d all like to be queen for a day, but most of us weren’t born into royalty. In the honey bee world, your queen status is also determined pretty early on—only 96 hours after hatching. New research has uncovered more epigenetic modifications that determine who gets to be queen bee. And who better to study […]

Neurons Make the Most of m6A mRNA Methylation

August 29, 2018

Move over DNA methylation, take a seat histone modification, it’s time to make room for RNA methylation. When you think of the importance of epigenetics to brain function and cognition, you probably think of well characterized changes DNA methylation, histone marks, and ncRNA. Well you better make some room in your own neural networks, because […]

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