epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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The State of Epigenetic Editing

September 27, 2012

If the field of epigenetics is heading into adolescence (rapid growth, disruptive, with occasional data tantrums), the arena of Epigenetic Editing (gene-specific rewriting of epigenetic marks) is more zygotic than anything, with far more questions than answers. But the concept of systematically manipulating epigenetic marks to modulate gene expression is injecting some air back into […]

Free White Paper: Histone Acetylation and Methylation – Epigenetic Modulators of Gene Expression

September 26, 2012

Histone acetylation and methylation are important cellular processes, but it can be hard keeping track of the structural ups and downs from HATs and HDACs. This free white-paper provides an informative, concise review of the key players in histone acetylation and methylation and their impact on specific residues. Download here >>>

RNA Methylation Adds Some Stability to a Chaotic Cell

September 26, 2012

We could all use a little more stability in our lives, and now researchers in Germany say that tRNAs get more stable when they are methylated on specific cytosines. This stability helps ensure that cells keep making proteins for proper development and differentiation. The role of cytosine-C5 methylation on tRNAs has been more mysterious than […]

NOMe-seq Goes Genome Wide

September 19, 2012

NOME-seq (Nucleosome Occupancy and Methylome Sequencing) made a big splash when it was introduced just over a year ago because of its novel ability to profile nucleosome positions and DNA methylation at the same time, on a single DNA strand. Now researchers from the University of Southern California Epigenome Center have powered-up the technique by […]

From A to G: The Ins and Outs of ChIP Beads

September 12, 2012

If you don’t run chromatin immunoprecipitation (ChIP) experiments on a daily basis, there’s a good chance that you find the dizzying variety of available immunoprecipitation bead choices a little overwhelming. We asked the ChIP experts from EMD Millipore to help us break down what you need to know about ChIP beads so that you choose […]

DNA Methylation Runs the Genomic Defense

September 12, 2012

Novel research findings over the last last five years have introduced more exceptions than rules in the field of DNA methylation in gene silencing. Whether DNA methylation stars as the cause or effect in the thickening regulatory plot continues to be discussed in labs around the world. A British team of researchers led by Dr. […]

EpiGenie Reviews Non-Coding RNAs and Epigenetic Regulation of Gene Expression

September 11, 2012

In recent years, studies exploring the modulation of gene transcription by non-coding RNAs have definitely been on the rise. This book, Non-Coding RNAs and Epigenetic Regulation of Gene Expression, written by a selection of highly regarded scientists, and edited by Kevin Morris, represents an overview and summary of this important new field to date. It’s […]

Predicting Gene Expression with Chromatin Features

September 11, 2012

As any weather forecaster can tell you, making accurate predictions is tough. But researchers now report that they’ve confirmed the power of chromatin features to predict gene expression. They’ve also come up with some new insights, too. Sure, some histone mods are associated with transcriptional repression, whereas others typically mark active spots. But many studies […]

Promoters Reach Out to Far -Away Elements

September 11, 2012

Now that the Olympic games are over, researchers in the ENCODE consortium have announced that they’ve just finished another Olympic effort of their own—the large-scale mapping of functional elements in the human genome. And just like the flexible “Fierce Five” U.S. women’s gymnastics team, it turns out that the genome is very bendy, looping around […]

Prediction Models Re-Write the Book on Nucleosome Occupancy and miRNA Targeting

August 23, 2012

A pair of newly released papers prove that you don’t always have to run more wet lab experiments to learn something new, you just need to look the data in a different way. The two research groups both used simulations and prediction algorithms, like the ones found on our Epigenetics Databases and Tools list, to […]