epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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ChIP Principles and Troubleshooting with Dr. Karen Halls

July 16, 2012

This webinar delivered by Dr. Karen Halls covers and introduction to chromatin and the ChIP process. It reviews protocols for ChIP, antibody selection, optimization of the method and includes troubleshooting guidance.

Guide: Simple Tips to Boost Your Bisulfite-Based Applications

July 11, 2012

Bisulfite conversion remains a key player in almost every study involving DNA methylation. Since DNA methylation is emerging as a key mechanism in a diverse range regulator processes and disease mechanisms, many researchers new to the field are turning to bisulfite-based analyses that might not be experts in the approach. We’ve been optimizing bisulfite […]

Step Up Your Bisulfite: DNA Methylation Analysis Tips for Challenging Samples

July 11, 2012

Sooner or later researchers studying DNA methylation turn it up a notch and get into some difficult sample scenarios, where the interesting data hides tucked away. We caught up with the R&D scientists at Zymo Research to hear more about some of the challenges that researchers face when stepping up into some of these sample […]

Free White Paper: Genome-Wide Analysis of RNA-Protein Interactions

July 3, 2012

Nowadays, with RNAs interacting with chromatin interacting with DNA methylation marks, researchers are keener than ever to get their gloves dirty with RNA Immunoprecipitation (RIP). If you fit that bill, then you’ll want to check out this white paper authored by Dr. André P. Gerber out of the Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland. […]

Wrapping Your Mind Around Brain DNA Methylomes

June 28, 2012

Not much is known about the normal DNA methylation differences between functionally different parts of the brain or how they relate to the patterns in peripheral tissues like blood. In a new study, scientists extensively mapped out the brain methylome to create a baseline resource for use in future research efforts. Researchers from King’s College […]

TACh Method Unlocks Chromatin Accessibility in Clinical Samples

June 28, 2012

Biobanks store valuable clinical samples that could provide a wealth of information about health and disease, but the secrets contained in these samples have been tough to get at with current technologies. But now, NIH researchers report a rapid new method called Tissue Accessible Chromatin (TACh) that could unlock these precious samples for chromatin analyses. […]

DNMTs Determine Radiation Sensitivity of Cancer Stem Cells

June 27, 2012

Radiation therapy usually works well against cancer, but some cells that survive the blast can divide and become unstable (cancerous) much later on, causing a relapse. Researchers initially thought that DNA hypomethylation was to blame for “delayed radiation-induced genomic instability,” but a new study in Epigenetics, August 2012 shows that, at least for embryonic stem […]

EMD Millipore AbSurance™ Histone Peptide Arrays: Insurance for Your Antibodies

June 23, 2012

It’s never a bad idea to insure the important things in life against disaster. Wouldn’t it be great if epigenetics researchers could do the same for an upcoming experiment? Although they aren’t exactly in the insurance game, EMD Millipore has designed the new AbSurance™ Histone Antibody Specificity Arrays to act as a protective policy against […]

NIH Roadmap Epigenomics Program Data Resource

June 18, 2012

Last August, we shared with you some of the great new online resources being developed by the NIH Roadmap Epigenomics Program. Now, the latest issue of Epigenomics, has published an update of all the latest editions, tweaks and refinements they’ve made over the last year. The NIH Roadmap Reference Epigenome Mapping Consortium has created a […]

Exosome miRNAs Tell Liver Damage Details

June 18, 2012

Sometimes many paths can lead to the same destination, and in the case of liver disease, it’s important for proper treatment to know the exact route that led to problems. New research shows that exosome miRNAs can tell scientists exactly how liver damage was caused. Several things, from chemicals to viruses, can trigger liver damage […]