epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Imprints Can Be a Real Turnoff

June 24, 2009

For at least 100 genes, only one of its alleles can be expressed right from the get-go while the other allele is shut down. This imprinted pattern remains throughout development. While cis-acting epigenetic elements have been implicated in the process, the research community doesn’t have enough evidence to conclusively pin the blame on any one. […]

tasiRNAs Get the Word Out

June 24, 2009

Spreading gossip around the water cooler is OK, but some news just has to be shouted from the mountaintops. These days, that means it’ll be posted to our blog, Twitter feed, and Facebook status box. Researchers at the Cold Spring Harbor Laboratory, Institut des Sciences du Végétal, and Institut de Biologie Moléculaire des Plantes report […]

Zeroing in on miRNA Targets with HITS-CLIP

June 24, 2009

With only a modest, 6-8 nucleotide seed region required for pairing, miRNAs theoretically aren’t too fussy when it comes to which mRNAs they pair up with. But don’t let this apparent “beer goggle” regulation fool you. When it comes down to miRNA binding in vivo, miRNAs might be a little more discriminating than previously suggested. […]

miRNA qRT-PCR Data Normalization Gets Mean

June 23, 2009

Although qRT-PCR has become a popular way to profile miRNAs, it has a dirty little secret that nobody likes to talk much about; data normalization. Without convenient “housekeeping genes” to use as internal references, like you would with mRNAs, researchers have had to settle for second rate options to normalize data from miRNA experiments. A […]

Move Over MeDIP: Methyl Binding Proteins Enrich Methylation Studies

June 18, 2009

Since their debut with tiling microarrays back in 2005, DNA methylation affinity reagents have rapidly become a weapon of choice for prepping samples for genome-wide methylation studies. In the last few years enrichment methods have evolved almost as rapidly as the technology platforms on which they’re analyzed. Let’s take a look at some of the […]

Gene Bodies Take the “Hot Bod” Title for 2009

June 18, 2009

Like many other websites looking to boost their traffic, we couldn’t resist calling attention to a few hot bodies. Back in the day, Golgi Bodies were a hot research focus, and for good reason–these mini protein boot camps put the final touches on our critical cellular proteins before sending them on to their job assignments. […]

DZNep Hints At New Wave Of Epigenetic Cancer Therapies

June 15, 2009

Although it may sound like the name of a DJ in a Vegas nightclub, DZNep is actually a histone methylation inhibitor, and has recently created some buzz when it was found to inhibit H3K27 and H4K20 methylation and reactivate silenced genes in cancer cells. Sensing the therapeutic possibilities, Peter Jones and his team at USC […]

If You Can’t Be With the One You Target, Target the One You’re With

June 11, 2009

It’s not news that miRNAs are out of whack in cancers. So it shouldn’t be surprising that re-expressing an oncogene-targeting miRNA might halt tumor progression. But what if the miR didn’t even have to target a specific oncogene to show off its anti-proliferative mojo? Son and father research duo (we’re pretty sure they dominated the […]

Methylation and HDAC Inhibitors Rouse Cancer-Fighting miRNAs into Action

June 11, 2009

Recent advances in epigenetic therapy are promising, but their mechanisms of action and impact elsewhere in the epigenome remain a bit of a mystery. Armed with microarrays and ChIP assays, a talented team of Japanese researchers took a closer look at these approaches and found DNA methylation inhibitors and histone deacetylase (HDAC) inhibitors kill gastric […]

DNA Methylation: Thinking Outside the Promoter to Determine Lineage

June 9, 2009

Promoters get all the glory when it comes to gene regulation. Sure, they’re important, but save a little love for enhancers—they may help cells decide what to be when they grow up! Historically, most methylation studies have focused on promoters, but instead of giving all the attention to these spotlight hogs, researchers at University Hospital […]

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