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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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DZNep Hints At New Wave Of Epigenetic Cancer Therapies

June 15, 2009

Although it may sound like the name of a DJ in a Vegas nightclub, DZNep is actually a histone methylation inhibitor, and has recently created some buzz when it was found to inhibit H3K27 and H4K20 methylation and reactivate silenced genes in cancer cells. Sensing the therapeutic possibilities, Peter Jones and his team at USC […]

If You Can’t Be With the One You Target, Target the One You’re With

June 11, 2009

It’s not news that miRNAs are out of whack in cancers. So it shouldn’t be surprising that re-expressing an oncogene-targeting miRNA might halt tumor progression. But what if the miR didn’t even have to target a specific oncogene to show off its anti-proliferative mojo? Son and father research duo (we’re pretty sure they dominated the […]

Methylation and HDAC Inhibitors Rouse Cancer-Fighting miRNAs into Action

June 11, 2009

Recent advances in epigenetic therapy are promising, but their mechanisms of action and impact elsewhere in the epigenome remain a bit of a mystery. Armed with microarrays and ChIP assays, a talented team of Japanese researchers took a closer look at these approaches and found DNA methylation inhibitors and histone deacetylase (HDAC) inhibitors kill gastric […]

DNA Methylation: Thinking Outside the Promoter to Determine Lineage

June 9, 2009

Promoters get all the glory when it comes to gene regulation. Sure, they’re important, but save a little love for enhancers—they may help cells decide what to be when they grow up! Historically, most methylation studies have focused on promoters, but instead of giving all the attention to these spotlight hogs, researchers at University Hospital […]

miRNA-Mediated Viral Attenuation Gives Vaccines a Boost

June 7, 2009

With all the recent talk of swine flu and pandemics, you might be wondering how the development of new flu vaccines is coming along. In an example of impeccable timing, researchers at the Mount Sinai School of Medicine now report that they’ve attenuated, two strains of the influenza A virus, the culprit behind swine, avian, […]

Curing Transposable Elements May Sicken Nearby Coding Genes

June 4, 2009

As in many aspects of life, curing the genome of transposable elements (TEs) may be a trade-off. To stop TEs from bouncing all over the genome, cells often resort to small RNA-mediated methylation. But researchers at UC Irvine have discovered that silencing TEs that settle in close to coding regions can reduce the expression of […]

Measuring Nucleosome Dynamics with CATCH-IT

May 25, 2009

When he’s not running his lab up at the Hutch or co-editing epigenetics’ only open source journal, Epigenetics and Chromatin, Dr. Steve Henikoff tinkers a bit (ok…that might be a bit of an understatement). Credited with inventing a range of useful research methods that have streamlined processes from sequencing to computational prediction tools, the Chicago […]

What is Suppressing The Suppressors?: Modified CTCFs linked to silenced tumor suppressors

May 20, 2009

Looking for exotic enzymes to silence tumor suppressor genes? You might be searching in vain. Maybe try looking for heterochromatin instead. Salk Institute postdoc Michael Witcher was baffled by what made p16INK4a not tick in breast cancer cells. He fed the genetic sequence into some prediction software, but it wasn’t much help. So he did […]

miRNA Discovery: Algorithms, Sequencing and Life Outside miRBase

May 12, 2009

Back in the early days, they were these interesting “genes” with names like “lin” and “let” that appeared highly involved in developmental timing, so much so that they were called small temporal RNAs (stRNAs). A lot more has changed in the field of miRNA discovery than naming mechanisms since those early days when the first […]

miRNAs Driving the Evolution of the Regulatory Cockpit

May 8, 2009

Recent discoveries in the field of epigenetics continue to transform the “light switch” examples of gene regulation with which the 30+ crowd was schooled into something a little more complicated…like an airplane cockpit. We’re not talking your average Cessna either, more like an Airbus A380. Evidence from a number of miRNA studies have added them […]

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