epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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mRNA Shows Its Age and Quiets Down the Immune System with Cap2 Methylation

February 14, 2023

Wrinkles, gray hair, … Cap2 methylation on mRNA? It turns out that these are all signs of aging. Two elegant new methods to show that Cap1 gets slowly modified to Cap2 as mRNAs age. And just like boomers, they want to live the quiet life, calming down the innate immune system to prevent autoimmunity. Although […]

One More Reason to Eat Your Wheaties: Your Microbiome and Histone Acetylation

February 7, 2023

We all know how important it is to eat fiber, whether in the form of fruits and veggies, or even a big bowl of fiber-rich cereal. Now, research from Ben Garcia’s lab (WUSTL) gives us one more reason to eat our Wheaties—our gut microbiome needs it to acetylate histones and possibly ward off diseases like […]

Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease Risk

January 30, 2023

Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these […]

scChIX-seq Brings Double the Fun to Single-Cell Histone Modification Profiling

January 23, 2023

How do you double your fun? An extra scoop of ice cream, coffee and a cake, or the epigenetic delights of single-cell profiling of not one but two histone modifications? In the latter case, the scChIX-seq (single-cell chromatin immunocleavage and unmixing sequencing) integrated framework may represent a wise choice for those looking to indulge while […]

Chromatin-Con 2023: Epigenetics of Aging Online Conference

January 19, 2023

Our friends and colleagues at Active Motif will be hosting an online conference focusing on the epigenetics of aging. Tune in if you can…Just take a look at the list of speakers and we’re sure you won’t want to miss it! Click over to the Active Motif website for more details and to register: Chromatin-Con […]

eBook: Epigenetics of Aging

January 16, 2023

Aging and longevity research has moved to the forefront of epigenetics in recent years. From DNA Methylation, to the Exposome and “translational inheritance” we are all avidly interested in this topic. In this eBook we review recent and intriguing research into this topic. Table of Contents Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging […]

Active DNA Demethylation as a Source of DNA Damage at Enhancers

January 3, 2023

Paint a self-portrait, build a house? If, instead, your more achievable New Year’s resolution was to be more active, new and exciting findings on how the abundance of single-strand DNA breaks (SSBs) at neuronal enhancers represents an intermediate of active DNA demethylation will be right down your alley! Researchers led by Wei Wu and André […]

Can Engineering Chromodomains Take Histone Methylation to “Affinity” and Beyond!?

December 4, 2022

The troupe of “toys” we use to explore the world of histone methylation just gained a new friend thanks to a playful team of epigenetic engineers who have taken histone modification-reading chromodomains to “affinity” and beyond! Researchers led by Gianluca Veggiani (Louisiana State University, USA) and Sachdev Sidhu (University of Waterloo, Canada) knew that histone-modification […]

Can New RNA Modification Profiling Tools Help in Your Epitranscriptomic Bid for Glory?

November 21, 2022

Two new sequencing methods may just make your day if you happen to be bidding for glorious insights into the epitranscriptome. Inspired by the bisulfite conversion used to assay DNA methylation, BID-seq and GLORI now enable single-nucleotide transcriptome-wide profiling of two crucial RNA modifications – N6-methyladenosine (m6A) and pseudouridine (the C5-glycoside isomer of uridine). RNA […]

An Inflammatory Microclimate Seeds a Super-enhancer That Drives Tumorigenesis

November 7, 2022

While microclimates shape environments along coastlines and urban jungles, this phenomenon isn’t restricted to macroscopic landscapes; now, a new study provides evidence that inflammatory signaling from the tumor microenvironment (TME) alters the epigenetic landscape by inducing the formation of a super-enhancer (SE) that drives tumorigenesis. An environmentally-friendly team led by Ramon E. Parsons (Icahn School […]