epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Going Green! – How Histone Recycling Promotes the Preservation of Pristine Epigenetic Landscapes

March 6, 2023

The climate crisis and our need to produce less waste have made recycling an everyday concept; however, whether histone proteins “go green” during DNA replication has remained somewhat in doubt. The epigenetic environment becomes disrupted during DNA replication and must be restored to maintain genome regulation and cell identity; now, two high-efficiency epigenetic studies provide […]

One-Stop Sequencing: Simultaneous Genetic and Epigenetic Information

March 2, 2023

Some shoppers like to browse several stores, whereas others follow the Amazon approach and want to just visit one place to buy everything on their list. The lab of Shankar Balasubramanian’s (University of Cambridge) must be in that second group because they developed a sequencing method that is a true one-stop extravaganza. It rings up […]

DNA Methylation Editing Provides Evidence for Transgenerational Epigenetic Inheritance in Mammals

February 26, 2023

While we have become familiar with the link between DNA methylation and disease, an exciting epigenetic editing study now reports how DNA methylation contributes to transgenerational epigenetic inheritance in mammals and influences disease-associated traits across generations! In their previous study, a talented team led by Juan Carlos Izpisua Belmonte at the Salk Institute for Biological […]

Multiplexed Epigenome Editing Rouses a “Sleeping Dog” to Treat a Neurodevelopmental Disorder

February 20, 2023

“Let sleeping dogs lie” is sound advice for those who want to stay out of trouble! However, an eye-opening epigenome editing study now suggests that rousing the “sleeping” methyl CpG-binding protein 2 (MECP2) gene from the inactive X chromosome may represent a therapeutic opportunity for girls with Rett Syndrome – an X-linked neurodevelopmental disorder that […]

mRNA Shows Its Age and Quiets Down the Immune System with Cap2 Methylation

February 14, 2023

Wrinkles, gray hair, … Cap2 methylation on mRNA? It turns out that these are all signs of aging. Two elegant new methods to show that Cap1 gets slowly modified to Cap2 as mRNAs age. And just like boomers, they want to live the quiet life, calming down the innate immune system to prevent autoimmunity. Although […]

One More Reason to Eat Your Wheaties: Your Microbiome and Histone Acetylation

February 7, 2023

We all know how important it is to eat fiber, whether in the form of fruits and veggies, or even a big bowl of fiber-rich cereal. Now, research from Ben Garcia’s lab (WUSTL) gives us one more reason to eat our Wheaties—our gut microbiome needs it to acetylate histones and possibly ward off diseases like […]

Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease Risk

January 30, 2023

Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these […]

scChIX-seq Brings Double the Fun to Single-Cell Histone Modification Profiling

January 23, 2023

How do you double your fun? An extra scoop of ice cream, coffee and a cake, or the epigenetic delights of single-cell profiling of not one but two histone modifications? In the latter case, the scChIX-seq (single-cell chromatin immunocleavage and unmixing sequencing) integrated framework may represent a wise choice for those looking to indulge while […]

Chromatin-Con 2023: Epigenetics of Aging Online Conference

January 19, 2023

Our friends and colleagues at Active Motif will be hosting an online conference focusing on the epigenetics of aging. Tune in if you can…Just take a look at the list of speakers and we’re sure you won’t want to miss it! Click over to the Active Motif website for more details and to register: Chromatin-Con […]

eBook: Epigenetics of Aging

January 16, 2023

Aging and longevity research has moved to the forefront of epigenetics in recent years. From DNA Methylation, to the Exposome and “translational inheritance” we are all avidly interested in this topic. In this eBook we review recent and intriguing research into this topic. Table of Contents Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging […]

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