Cognitive Benefits of Dad’s Enriched Environment Passed to Offspring Through Sperm miRNAsMay 25, 2018With Father’s Day just around the corner, it’s the time of year we think about how we can “enrich” Dad’s life with power tools, gift cards, and hand-made crafts. But maybe we should be looking into enriching Dad’s cognitive environment because it turns out that he can pass those benefits on. In mice, the environmental […]
Keeping it CLASSY with RNA-directed DNA Methylation in ArabidopsisMay 22, 2018There’s many ways to keep it classy, and while the recent Royal Wedding has demonstrated that some families illustrate their style with an eclectic taste for hats and fascinators, the CLASSY family of chromatin remodeling factors has just out-classed them with its chromatin tastes that shape RNA-directed DNA methylation. In Arabidopsis thaliana, RNA Pol-IV triggers […]
Sea Snails Thank RNA-induced DNA Methylation for the Long-term Memories!May 16, 2018Forget everything you know about memories (!) because a new study has turned our knowledge regarding memory formation on its head by showing the ability to transfer memories from animal-to-animal! Current dogma states that learning-induced modifications of synaptic connections underlie the storage of our long-term memory (LTM); however, recent studies have suggested that neuron cell […]
C. elegans Histone Memory of a Tropical VacationMay 14, 2018Most of us wouldn’t mind taking a tropical vacation, and we’re all likely to snap a few selfies to capture vacation memories. While the humble Caenorhabditis elegans may lack the latest phone and accompanying selfie stick, it makes up for it with epigenetic memory of warm weather vacations. More specifically, worms raised at higher temperatures undergo […]
Snord116 Keeps DNA Methylation’s Circadian Rhythm Ticking in the BrainMay 10, 2018Sunrise, Sunset. The tempo of a day can quickly pass us by while filling our brain with all epigenetics has to offer. But whether our brains are aware of it or not, with each sunrise and sunset comes a rhythmic genome-wide DNA methylation profile. To gain insight into exactly what makes our brain’s rhythmically tick, […]
EpiTOF Histone Modification Analysis Reveals How Aging Cells Grow Apart!May 9, 2018Some say that all babies look the same – small, warm bags of tears and mayhem – with significant differences only appearing as we grow older and grow apart from our newborn brethren (and sistren!). Our burgeoning epigenome may react to aging in a very similar manner, with age-related losses and gains of DNA methylation combining […]
Two Barcodes, One DNA Fragment: Budget-Friendly Single-Cell Whole-Genome Bisulfite SequencingApril 29, 2018While single-cell whole-genome bisulfite sequencing is rapidly evolving, the associated price tag hasn’t been quite as dynamic. This lack of dynamism is primarily because current single-cell whole-genome bisulfite sequencing (scWGBS) methods are limited by the need to process each cell in individual reaction vessels and also low alignment rates. These limitations mean a high (financial) […]
TERRA lncRNA Tailors a Trimethylation Trio at TelomeresApril 27, 2018A good tailor will make any scientist look presentable in an expensive suit or a glitzy dress (when we escape the confines of a lab coat) and now, the group of Maria A. Blasco (CNIO, Madrid, Spain) describes how long non-coding RNAs (lncRNAs) tailor our telomeric DNA with just enough trimethylated histones to suit any […]
Transposons and DNA Methylation Learn to Get AlongApril 26, 2018A lot of things just don’t mix well, dogs and cats, oil and water, and as most geneticists would agree, transposons and DNA methylation. DNA methylation is the mortal enemy of transposon activity; across the tree of life it has a conserved role silencing transposable elements from plants, to algae, to vertebrates. This suggests DNA […]
dmrseq Powers-Up Whole-Genome Bisulfite Sequencing AnalysisApril 16, 2018In our modern world, power is everything. Whether it be political, social, or even statistical, humankind always thirsts for more. While political and social power may be a little beyond our scope, a new bioinformatic package has come forth to power up your ability to detect differentially methylated regions (DMRs) from whole-genome bisulfite sequencing (WGBS) […]