epigenetics

Epigenetics and ncRNA Headlines

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MicroRNA Isoforms Distinguish Between Breast Cancer Subtypes

October 6, 2015

Much like the early explorers who set out to find a new trade route to Asia and accidentally stumbled across the Americas, researchers mapping the transcriptome have come across some big surprises. Recently, Isidore Rigoutsos’s lab showed that the expression of microRNA isoforms (called ‘isomiRs’) and tRNAs depends on sex, population, and race. Now, this […]

Stressed Nucleosomes Linked to Depression

October 6, 2015

Have you ever felt stressed and even depressed? Well, a new study linking stress-induced depressive behaviors to changes in nucleosome positioning suggests that in order to relax yourself, you may first need to relax your chromatin. Susceptibility to major depressive disorder (MDD) depends on genetic variability but also on environmental factors such as a stressful […]

New Reporter System Captures DNA Methylation in Real Time

October 1, 2015

If a picture is worth a thousand words then surely a video must be worth more? So far, our knowledge about DNA methylation has been limited to a comic strip of static images at different stages. That may all be about to change with a new tool reported by the lab of Rudolf Jaenisch, which […]

Microfluidic ChIP Makes a Few Cells Go a Long Way

September 11, 2015

Chromatin immunoprecipitation (or ChIP) is a handy technique to study epigenetic profiles, but only if you have enough cells. The main problem with ChIP is that it can be a “greedy” technique that uses large numbers of cells while giving back the bare minimum of DNA as a result. This is problematic for the study of genome-wide […]

A Polymerase Evolved for Your Bisulfite Converted DNA

September 11, 2015

Bisulfite conversion can be used in so many different applications that it’s not so surprisingly referred to as the gold standard for DNA methylation analysis. But getting to the gold can create some problems for DNA. The process of converting methylated DNA (5mC) to Uracil and then finally a Thymine is harsh as it involves […]

Custom-Made Histone Modifications Add Some Bling to Chromatin

September 11, 2015

Sure, the new Apple products announced this week represented new breakthroughs and yes, you’ll be able to personalize these devices with countless modifications like cases, color and screens. The real action though, was unfolding (pun intended) in the world of chromatin analysis as a new method surfaced for introducing tags or native modifications into histones (or any other […]

DNA Methyltransferase Teams Up with Long Non-Coding RNA to Police Colon Cancer Cells

September 5, 2015

Mulder and Scully. Holmes and Watson. If TV and books are anything to go by, then unconventional pairings between the hot-headed detective and their calm and collected partner get results. Now it seems that another unlikely duo work together in the fight against crime of a biological nature. A new study reports that a DNA […]

ChIPmentation: The Next Fast and Low-Input ChIP-seq Sensation

August 25, 2015

ChIP-Seq is the bread and butter of histone and transcription factor research. It has seen countless modifications to allow it to perform under all the variables biology can throw at it, but with that specialization has come limitations to generalization. Now the methodological maestros in the lab of Christoph Bock, which brought us single-cell methylome sequencing, […]

Epigenetics Drives Genetics Straight Into Evolution

August 9, 2015

In today’s fast-paced world, quickly adapting to your environment is a game-changer. But genetic determinism cannot fully explain the rapid adaption seen in many species, which has left evolution in a dark age. That is until the enlightening work of Michael Skinner’s laboratory at Washington State University. Their observations on transgenerational epigenetic inheritance have been […]

Lights Out! Sleep Loss Affects DNA Methylation of Circadian Genes

August 4, 2015

‘La nuit blanche’. No, it is not a delicious pastry. It’s the French expression for staying up all night and not going to bed until the next evening, which in most cases will leave you pretty irritable. But losing one night’s sleep may affect more than just your mood; a new study by Swedish […]

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