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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Mining the Transcriptome

April 17, 2009

As the herculean genome sequencing efforts closed in on a draft of the human genome sequence back in 2000, the estimated numbers of “genes” that comprised our genome dropped quicker than the market cap of the biotech heavy Nasdaq after Clinton/Blair announced the sequences of these little gems would reside in the public domain. Shortly […]

Genome Sequence Affects Heterochromatin Spreading

April 17, 2009

The establishment of heterochromatin is an important way for cells to repress transcription. Yet not much is known about the control of heterochromatin spreading into euchromatic domains. Therefore, researchers at Duke University used the Awesome Power of Yeast (Epi)Genetics to study how specific DNA sequences affect heterochromatin spreading. Their results are published in the April […]

Huh? miR-96 Tied to Hearing Loss

April 17, 2009

Over the years, mothers around the world have routinely warned their children of the imminent hearing loss resulting from too many Iron Maiden concerts, blasting Winger too loud on car stereos, or the permanently attached iPod earbuds that come standard with adolescents nowadays, but now we have scientific data to suggest our mothers and miR-96 […]

miRNA Promoter Elements Driving Cell-Specific Expression

April 10, 2009

Whether you’re talking about real estate or miRNA expression, the phrase “location, location, location” expresses the undeniable importance of surroundings. Like protein-coding genes, miRNA genes can be turned on or off depending on the cellular context. However, mechanisms responsible for cell-specific miRNA expression are largely unknown because miRNA promoters are not as well characterized as […]

The Search for Histone Classifiers in ESC and NSC Screening

April 10, 2009

Stem cell researchers have been pretty amped since last month’s presidential decision to bulldoze funding restrictions on human embryonic stem cells. We know the Scripps Institute’s Center for Regenerative Medicine even threw a “Stem Cell Freedom Party” to celebrate. We weren’t able to attend unfortunately, but we’re sure there was some crazy behavior. After all, […]

New Analysis Combos Reveal More Gene Body DNA Methylation

April 10, 2009

Hey, sometimes more really is, well, more. Lately in the sequencing arena, we’ve heard a lot about some really slick advances in targeted sample enrichment and other ways to sequence less real estate in exchange for more coverage and better data. Such enrichment methods should be equally useful to epigenetics as they are in current […]

Feel the Burn: Epigenetic Changes After Exercise Improve Stress Response

April 10, 2009

At EpiGenie, we’ve been struggling to find the time and motivation for exercise since we misplaced those Tae Bo tapes. Sure the treadmill would work, but then we’d have to move all the clothes hanging on it. However, some recent work from researchers at the University of Bristol in the UK, caught our attention. The […]

DNA Methylation, the NIH Epigenomics Program, and What’s Next in Epigenetics

April 1, 2009

Joseph Francis Costello received his Ph.D. at Loyola University in Chicago, Illinois where he and his mentor, Dr. Russell Pieper discovered aberrant DNA methylation of the MGMT promoter in glioblastomas, which has since become the most widely used molecular marker to predict patient response to chemotherapy. In 1995, he became a postdoctoral fellow at the […]

Research Team Takes a Deep Dive into Chromosome 21 Promoter Methylation

April 1, 2009

When it comes to knowledge about DNA methylation sites in the human genome, there’s no such thing as too much information. That’s why researchers in Germany have mapped DNA methylation sites on chromosome 21 in exquisite detail?with single base pair and single allele resolution. Their results are reported in the March 27, 2009 issue of […]

Inside the DNA Methylation-Chromatin Tango

April 1, 2009

There has been a ton of interesting data on the relationship between DNA methylation, histone modifications, and transcriptional control in recent years. We love hearing about these advances at conferences, but die-hard chromatin biologists tend to rattle off histone modification combos that sound like a football quarterback about to take a snap “H3K27-trimethyl, K9, hike…,” […]

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