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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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The Search for Histone Classifiers in ESC and NSC Screening

April 10, 2009

Stem cell researchers have been pretty amped since last month’s presidential decision to bulldoze funding restrictions on human embryonic stem cells. We know the Scripps Institute’s Center for Regenerative Medicine even threw a “Stem Cell Freedom Party” to celebrate. We weren’t able to attend unfortunately, but we’re sure there was some crazy behavior. After all, […]

New Analysis Combos Reveal More Gene Body DNA Methylation

April 10, 2009

Hey, sometimes more really is, well, more. Lately in the sequencing arena, we’ve heard a lot about some really slick advances in targeted sample enrichment and other ways to sequence less real estate in exchange for more coverage and better data. Such enrichment methods should be equally useful to epigenetics as they are in current […]

Feel the Burn: Epigenetic Changes After Exercise Improve Stress Response

April 10, 2009

At EpiGenie, we’ve been struggling to find the time and motivation for exercise since we misplaced those Tae Bo tapes. Sure the treadmill would work, but then we’d have to move all the clothes hanging on it. However, some recent work from researchers at the University of Bristol in the UK, caught our attention. The […]

DNA Methylation, the NIH Epigenomics Program, and What’s Next in Epigenetics

April 1, 2009

Joseph Francis Costello received his Ph.D. at Loyola University in Chicago, Illinois where he and his mentor, Dr. Russell Pieper discovered aberrant DNA methylation of the MGMT promoter in glioblastomas, which has since become the most widely used molecular marker to predict patient response to chemotherapy. In 1995, he became a postdoctoral fellow at the […]

Research Team Takes a Deep Dive into Chromosome 21 Promoter Methylation

April 1, 2009

When it comes to knowledge about DNA methylation sites in the human genome, there’s no such thing as too much information. That’s why researchers in Germany have mapped DNA methylation sites on chromosome 21 in exquisite detail?with single base pair and single allele resolution. Their results are reported in the March 27, 2009 issue of […]

Inside the DNA Methylation-Chromatin Tango

April 1, 2009

There has been a ton of interesting data on the relationship between DNA methylation, histone modifications, and transcriptional control in recent years. We love hearing about these advances at conferences, but die-hard chromatin biologists tend to rattle off histone modification combos that sound like a football quarterback about to take a snap “H3K27-trimethyl, K9, hike…,” […]

Promoter Targeted Small RNAs Lay a Big Smack Down on Gene Expression.

March 31, 2009

Sometimes to get the correct result, a researcher needs to knock a gene down. Not just a little knockdown, but like a Mike Tyson knockdown! (well, at least back in the days before the whole ear-biting thing.) Some clever scientists at The Scripps Research Institute may have found a way to do just that. By […]

RNAi Rescues DNA Methylation Defects

March 25, 2009

Nowadays it seems like “interference” carries such negative connotations. RNAs aren’t really big meddlers. In fact, it’s RNAi that’s protecting genomes against the transgenerational loss of DNA methylation. A team of researchers in France and Spain has demonstrated that in Arabidopsis, the RNA interference (RNAi) machinery can remethylate target sequences that were hypomethylated by mutation […]

The PSA Debate and DNA Methylation Biomarkers

March 25, 2009

For many men, nothing can kick off a mid-life crisis quicker than a prostate exam. Middle-aged guys in sports cars everywhere dread reminders from their urologist for prostate checkups. Don’t even get us started on PSA’s infamous counterpart, the digital rectal exam. The prostate surface antigen (PSA) test was launched back in 1985 by Hybritech, […]

miR-101: RNA Guardian Of The Genome?

March 9, 2009

MicroRNA-101 (miR-101) is rapidly earning a place in the “Who’s Who” of tumor suppressor genes. In November, we told you how The Little RNA that Could wallops prostate cancer by repressing the histone methyltransferase EZH2. Now researchers at the University of Southern California have shown that miR-101 plays a similar role in the suppression of […]

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