The soaring Eiffel Tower in Paris, the tumultuous Guggenheim in Bilbao, or the intricate genome structure of a single cell; which architectural marvel impresses you the most? For the labs of Leonid A. Mirny and Kikuë Tachibana-Konwalski, the latter looms above any such extravagant edifice, but the available analytical tools lacked the resolution required for […]
Epigenetics and ncRNA Headlines
Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.
Mapping an undulating, dynamic, and partially hidden landscape represents a vexing problem to say the least, especially when the landmarks of interest are rare DNA demethylation by-products in a single cell! This is the task faced by those intrepid explorers hoping to map the genome-wide location of 5-formylcytosine (5fC), a fleetingly rare oxidized form of […]
While chromosome conformation capture (3C) methods like single-cell Hi-C focus on coupled pairs of chromosome contacts, and even their promiscuous regions, candid snapshots of chromosomal threesomes have remained an intimate secret … until now. The genomic architects in the labs of Ana Pombo and Mario Nicodemi developed a new method and accompanying statistical model to […]
Don’t you just hate when you’re trying to get from A to B and google maps can’t even figure out where you’re starting from? Well, just like your last trip to that hot new sushi place, the precise location of lncRNA origins has only been plotted with blurry lines. Thankfully, to aid the start of […]
Boots, check! Helmet, check! DNA Methylation, check? Any active individual will tell you that protecting your body is an integral part of keeping fit and healthy while enjoying your sport of choice. In the über-competitive world of DNA, a study from the teams of Francesco Neri and Salvatore Oliviero has proposed that DNA methylation on […]