EPIC Technique Infers Gene Expression from Cell-free DNA FragmentationMay 9, 2022It’s time to put down that well-thumbed copy of Homer’s Odyssey, as there is a new epic in town. Now, the “epigenetic expression inference from cell-free (cf)DNA-sequencing” (EPIC-seq) technique heroically enables gene expression analysis using a process known as “fragmentomics.” Circulating cfDNA comes as nucleosome-associated fragments that reflect the chromatin configuration in the cell of […]
Battling Against the Clock: Epigenetic Age Acceleration Impacts COVID-19 SeverityMay 2, 2022Timing is crucial for many aspects of life, and now, a rather timely study demonstrates that the acceleration of our epigenetic clocks after SARS-CoV-2 infection significantly impacts our risk of suffering severe COVID-19 and post-COVID-19 syndrome (“long COVID”). Previous research has described how older patients suffer from a higher risk of developing severe COVID-19 (independent […]
Rixosomes Take Out RNA to Keep Silent Polycomb-target Genes Quiet!May 2, 2022Some pesky Polycomb-target genes know too much about genome-wide goings-on, and while these nervous sections of DNA might keep silent for now, how can we ensure that our cells maintain this code of silence? It turns out that human cells, just as in yeast, possess an enforcer that mercilessly chops up RNA messages produced from […]
EpiDamID Contains a Flood of Histone Modification Findings from Single Cells!May 2, 2022Lately, we’ve been faced with a veritable torrent of awesome single-cell epigenomics methods; thankfully, the development of a new technique – EpiDamID – promises to easily contain the floods of findings regarding histone modification and gene expression patterns coming from single cells! Previously, a talented team from the lab of Jop Kind (Hubrecht Institute, Utrecht, […]
Cell Surface Protein Profiling Gives Single-cell CUT&Tag a Pro UpgradeApril 25, 2022Nothing beats a Pro upgrade, and lately, researchers have given CUT&Tag the deluxe treatment. This chromatin profiling method received its first improvements with the releases of scCUT&Tag and then Spatial-CUT&Tag; now, we’ve been treated to a view of the cell surface protein profile in its latest form. A pro team of single-cell explorers from the […]
