Evolution Uses Bivalent Chromatin to Control Mammalian DevelopmentJune 22, 2016A big event always requires a bit of prior preparation, and for evolution, mammalian development is no exception. The mammalian body plans have undergone massive evolutionary rearrangements and diversifications requiring the evolution of complex gene expression profiles. Recent studies in specific tissues in mammalian species have now linked these expression changes to the evolution of […]
Enjoy Chromatin Highs and Lows with Chromatrap®’s ChIP-Seq KitsJune 17, 2016Chromatin analysis experiments can be a roller coaster of emotion. One moment you’re flying high and the next you’re in a troubleshooting inferno. Fortunately, there has been quite a bit of competition to fine-tune nearly every portion of the ChIP sequencing workflow over the last few years, and those advancements are now benefitting researchers like […]
Synthesizing A Human GenomeJune 16, 2016One score and six years ago, humanity embarked upon the Human Genome Project (HGP), sequencing all 3 gigabases of our genetic instruction manual. More than 1000 human genomes later, a consortium of synthetic biology heavy-hitters has proposed a new grand challenge. Appending “-Read” to the first project, they now propose Human Genome Project-Write, a quest […]
Watch out Cas9: Cpf1 Hits the Mark in Human Cells and Creates a Mouse ModelJune 15, 2016In the Wild West of CRISPR genome editing, Cas9 has established itself as a wrangler of animal models that takes out any sequence with an sgRNA bounty on its head. But now there’s a new sheriff in town with marksman aim. CRISPR from Prevotella and Francisella 1 (Cpf1) was brought forth by the pioneering lab […]
New C2c2 CRISPR Turns The Tables on RNAJune 15, 2016In the CRISPR hype up to now, DNA has gotten a raw deal. In all known CRISPR systems, RNA guides gang up with protein effectors (e.g., Cas9 and Cpf1) to chop up poor, abused DNA helices. Now, a new CRISPR protein – C2c2 – is giving DNA a reprieve, turning the tables on RNA instead. […]
