RIP Into RISC Proteins with System Biosciences’ miR-SNaREsApril 14, 2009Small Non-coding RNA Enrichment Can Be RISCy Things can get complicated when you are looking for low copy miRNAs, validating miRNA targets or trying to figure out all of the players in RISC complexes. SBI’s miR-SNaREs™, enable you to lasso those answers easily. The system uses Lentivectors to overexpress different flavors of epitope tagged microRNA processing […]
miRNA Promoter Analysis with Custom ChIP-Chip ArraysApril 11, 2009Last time we checked there weren’t any miRNA Promoter Arrays out there in the market and even if there were, they’d likely be out of date, so if you’re ready to roll up your lab sleeves and dive into the transcriptional regulation of miRNAs, you’ll want to check into custom array designs like Agilent’s eArray. These custom, ink […]
miRNA Promoter Elements Driving Cell-Specific ExpressionApril 10, 2009Whether you’re talking about real estate or miRNA expression, the phrase “location, location, location” expresses the undeniable importance of surroundings. Like protein-coding genes, miRNA genes can be turned on or off depending on the cellular context. However, mechanisms responsible for cell-specific miRNA expression are largely unknown because miRNA promoters are not as well characterized as […]
The Search for Histone Classifiers in ESC and NSC ScreeningApril 10, 2009Stem cell researchers have been pretty amped since last month’s presidential decision to bulldoze funding restrictions on human embryonic stem cells. We know the Scripps Institute’s Center for Regenerative Medicine even threw a “Stem Cell Freedom Party” to celebrate. We weren’t able to attend unfortunately, but we’re sure there was some crazy behavior. After all, […]
New Analysis Combos Reveal More Gene Body DNA MethylationApril 10, 2009Hey, sometimes more really is, well, more. Lately in the sequencing arena, we’ve heard a lot about some really slick advances in targeted sample enrichment and other ways to sequence less real estate in exchange for more coverage and better data. Such enrichment methods should be equally useful to epigenetics as they are in current […]
