DNA Methylation Analysis Puts a Face to a Very Ancient NameOctober 1, 2019A long, long time ago, in a land far, far away (2014 at the Hebrew University of Jerusalem, Israel actually!) a team of researchers banded together under the leadership of Liran Carmel and David Gokhman. Rather than inventing the wheel or devising a strategy to capture wooly mammoth, the team developed a way to reconstruct […]
Sherlock Genomes: Stimulation Leaves Epigenetic Evidence Behind in NeuronsSeptember 30, 2019Even the most careful criminals leave some kind of evidence; a fingerprint or a strand of hair can be enough for a clever investigator to link them to the scene of the crime. Although it’s far from an open and shut case, new research in mice shows that the epigenome of neurons contains chromatin clues […]
The Tn5 Transposase Takes Single-cell ChIP-Seq to the Next LevelSeptember 18, 2019It’s never good to see someone lagging behind the rest, but while stepwise developments to single-cell chromatin immunoprecipitation and subsequent parallel sequencing techniques (ChIP-seq) have led to gradually improved yields and increased sensitivity with reduced numbers of cells since the first report of a single-cell ChIP protocol, we still lack widely-applicable and low-cost methods to […]
Epitranscriptomic Editing: m6A RNA Methylation Tools Join the CRISPR Arms RaceSeptember 11, 2019CRISPR-Cas9 genome editing has revolutionized not only the way genomes are modified, but thanks to deactivated Cas9 (dCas9) and it’s growing arsenal of effector domains, it has also provided the tools needed for the epigenome editing revolution. However, to date, the tools to modify RNA itself have been lagging behind in the epigenome editing arms […]
Maladaptive Memories are Mediated by Methylated Histones and ΔFosB in the Mouse HippocampusSeptember 10, 2019The air is starting to get crisp, the first few leaves are changing color and you can suddenly buy pumpkin-spice everything – these contextual cues can only mean one thing; you’d better start studying for your midterms! But wait, you haven’t had to worry about exams for years… Thanks to your hippocampus and epigenetics, environmental […]
