CpH DNA Methylation Steps Out of the CpG Shadow During Brain DevelopmentNovember 4, 2019DNA methylation and CpG sites just go together, so in fact well that sometimes we forget that DNA methylation can happen in other cytosine contexts too! With new advances in sequencing technologies, non-CpG methylation is stepping out of the shadows and being seen for the important role it plays. DNA methylation is particularly important in […]
Histone Hangover: Alcohol Metabolism Actively Alters Acetylation in the BrainNovember 4, 2019We’ve all been warned — from our teachers, our parents, or from outrageous college movies — if you overindulge with booze you may not remember much the next morning. Now, exciting new research shows that an alcohol metabolite can alter our brain’s histone acetylation and can mix up memories at the molecular level. Neurons make […]
Single Cell Analyses Reveal How Epigenetic Drift Makes Stem Cells Age Badly!October 28, 2019While cheese and wine (and whisky!) all get better with age, the human body fares less well! Although partaking in too many culinary delights hardly helps, studies have established the reduced number and activity of stem cells as a cause for the age-related deterioration of various tissue types. With this in mind, a talented team […]
Foretelling Future Hippocampal Transcription and Disease Risk with Early DNA Methylation ProfilesOctober 27, 2019Will it rain tomorrow? Will I ever win the lottery? Will our new paper finally be accepted!? Unfortunately, we have yet to come up with a sturdy means to predict our fates far in the future; however, new research by Hadad and colleagues now suggests that DNA methylation profiles in young cells accurately foretell changes […]
Studying TAD Boundary Issues Through Epigenome Editing of CTCF MotifsOctober 19, 2019So, your therapist says you have boundary issues? Well you’re not alone; CTCF is known to play a critical role in setting the boundaries of topologically associating domains (TADs), but there’s been no therapist to uncover their definitive impact. Thankfully, new research from the lab of Bradley Bernstein at the Harvard Medical School (Boston, USA) […]
