DNA Origami For Smart Membrane ChannelsJanuary 28, 2016DNA is pretty great for a lot of reasons. There is the whole “central component of life,” of course, but DNA is also a pretty great building material. Making super-tiny, nano-scale objects seems like a really hard problem, but biology does this all the time. Life’s standard nano-brick is protein, but proteins are difficult to re-engineer, […]
DNA Methylation and Transcription Data from Single Stem CellsJanuary 28, 2016Ever wanted to be able to do two things at the same time? Like work and have a social life? Eat pizza and still fit in your new purchases? Pat your head and rub your belly? While these highly important combinations remain almost impossible (at least for the EpiGenie staff), a stellar cast of scientists […]
RNA Hydroxymethylcytosine Targets the MessengerJanuary 28, 2016A new paper adds another RNA modification to the list already published, but with exciting news for the epigenetics enthusiasts out there… the characterized modification is RNA 5-hydroxymethylcytosine (5hmrC), an important mark previously discovered on DNA. The laboratory of François Fuks at ULB in Brussels decided to look deeper into the presence of 5hmC on […]
Viva in vivo Gene Editing: A Roundup of the Latest CRISPR HitsJanuary 28, 2016Gene editing with CRISPR/Cas9 is here, there, and everywhere. We have seen gene editing in human somatic cells, pluripotent stem cells, and even embryos. However, we should also be looking at CRISPR-based gene editing somewhere else: in a living, breathing human. The question is – where does the current technology stand on the in vivo […]
Casilio: a CRISPR/Cas9 and Pumilio Hybrid for Epigenome EditingJanuary 24, 2016Life is full of challenges, and when that challenge is epigenome editing even a rock star like CRISPR/Cas9 stands to benefit from helping a hand. Epigenome editing with CRISPR/Cas9 involves using a dead Cas9 (dCas9) that confers the precision of the genome editing system without nuclease activity. The standard approach involves utilizing a fusion protein […]
