A “Batty” New Epigenetic Clock Provides Clues About Healthy AgingApril 8, 2021Are you cuckoo for clocks, dotty for DNA methylation, and avid about aging? Well, a “batty” new study of epigenetic aging in certain long-lived winged mammals has just added to the zoo of clues about epigenetic age by providing a bat epigenetic clock. Specifically, an ardent team of researchers led by the levels heads of […]
From Single Molecules to Single Cells: NanoMethPhase and scMspJI-seq Upgrade DNA Methylation Mining MethodsApril 2, 2021Mining the DNA methylome can provide a treasure trove of biological insight, and two new whole-genome DNA methylation sequencing methods have come along to fuel a technological gold rush. NanoMethPhase and scMspJI-seq break new ground in phasing allele-specific methylation (ASM) and generating strand-specific single-cell methylomes. By applying these novel approaches, the talented teams dig deep into complex DNA […]
The Solution to Stop Stress Susceptibility: Spiny Neuron Histone H3K79me2 ModificationsMarch 29, 2021Many of us dream of a quick fix to being so stressed all the time, and now that reality may not be so far off thanks to the identification of a histone modification behind the life-long effects of early-life stress (ELS). The nucleus accumbens is a brain region important for dopamine signaling and reward behavior. […]
Cancer-associated Histone Mutations Modulate Nucleosome Remodeling to Get That Histone Body Moving!March 26, 2021While any new study mentioning histones generally gets our epigenetic tails wagging, a stunning study into how cancer-associated histone mutations influence nucleosome remodeling has also got our “globular” bodies moving! Although most researchers focus on mutations in the histone tail, most high-frequency cancer-associated mutations actually affect the main “bodies” of the histone proteins (known as […]
AtacWorks: Deep Learning Levels Up ATAC-seq with Graphics Processing UnitsMarch 19, 2021It turns out that those graphics cards in our computers aren’t just great for gaming, they can also push your epigenomic research to the next level. When industry meets academia, we can all win and thanks to an exciting collaboration between the graphics processing unit (GPU) inventors at NVIDIA and the lab of ATAC-seq inventor […]
